A5101837741- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Genetics and Neurodevelopmental Disorders
- Synthesis and Catalytic Reactions
- Immune Response and Inflammation
- Biological Activity of Diterpenoids and Biflavonoids
- Sulfur-Based Synthesis Techniques
- Prostate Cancer Treatment and Research
- Brain Metastases and Treatment
- Synthesis of Organic Compounds
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- Signaling Pathways in Disease
- Cancer Immunotherapy and Biomarkers
- TGF-β signaling in diseases
- Catalytic C–H Functionalization Methods
- MRI in cancer diagnosis
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Food Industry and Aquatic Biology
- Neurogenesis and neuroplasticity mechanisms
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Flavonoids in Medical Research
- Peptidase Inhibition and Analysis
First Affiliated Hospital of Xi'an Jiaotong University
2011-2023
Sichuan Mianyang 404 Hospital
2022
Sun Yat-sen Memorial Hospital
2018-2021
Sun Yat-sen University
2018-2021
Guiyang Medical University
2019
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2019
Zunyi Medical University
2019
Baoji University of Arts and Sciences
2019
State Council of the People's Republic of China
2018
Focused ultrasound neuromodulation (FUN) is widely regarded as a next-generation technology for neural modulation, with applications spanning rodents, non-human primates, and humans. While mechanistic studies are advancing, persistent confound-auditory interference-casts doubt on whether exerts direct mechanical effects or merely indirect auditory responses. To resolve this, we engineered circular transducer compatible two-photon calcium imaging examined its the primary visual cortex (V1) of...
<h3>Objective:</h3> To explore the genetic changes in progression of castration-resistant prostate cancer (CRPC) and neuroendocrine (NEPC) reason why these cancers resist existing therapies. <h3>Methods:</h3> We employed our CRPC cell line microarray other or NEPC datasets to screen target gene NEIL3. Lentiviral transfection RNA interference were used construct overexpression knockdown lines. Cell animal models radiotherapy established by using a medical electron linear accelerator. Flow...
The aim of the present study was to compare diagnostic performance main parameters derived from diffusion kurtosis imaging (DKI), intravoxel incoherent motion (IVIM) and diffusion-weighted (DWI) regarding detection grading hepatocellular carcinoma (HCC). A total 78 patients diagnosed with HCC by biopsy were prospectively enrolled in study, underwent routine magnetic resonance (MRI), DWI, IVIM, DKI contrast-enhanced MRI prior surgery. Measurements, including mean diffusivity (MD), diffusional...
Background: Breast cancer (BCa) is a serious global healthy burden among females and the increasing endocrine resistance becomes major BCa treatment challenge. This study aimed to investigate expression of Toll-like receptor 2 (TLR2) in patients, evaluate prognostic value TLR2 its predictive potential for resistance. Methods: A total 150 patients were recruited this study, including 82 cases underwent therapy. Expression mRNA was examined using quantitative Real-Time PCR, evaluated...
The high recurrence and improved survival rate of clear-cell renal cell carcinoma (ccRCC) demand for continuous effort to search novel prognostic factors. Herein a comparative proteomics approach based on two-dimensional polyacrylamide gel electrophoresis (2-DE) matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was used identify differentially expressed proteins between ccRCC line RLC-310 normal HK-2. Of the 31 identified, Cyclophilin A (CypA) newly...
Seventeen new flavone derivatives substituted at the 4'-OH position were designed, synthesized and evaluated for their anticancer antibacterial activities. Among them, compounds 3, 4, 6f, 6e, 6b, 6c 6k demonstrated most potent antiproliferative activities against a human erythroleukemia cell line (HEL) prostate cancer (PC3). The results also showed that IC50 value of close to drug cisplatin (DDP) lower than apigenin. All did not present structure-activity relationships evaluation...
Brønsted-acid-catalyzed allylic substitution reactions of the in situ generated 3-hydroxy indanones with alcohols and sulfamides were investigated, which provided a facile route for synthesis large variety 3-alkoxy 3-sulfamido indanones. The key intermediates, indanones, obtained through intramolecular Meyer-Schuster rearrangement o-propargyl alcohol benzaldehydes. resulting 3-benzyloxy indanone could be selectively modified by sulfonamidation reduction reactions.
Neural stem cells (NSCs) exhibit preferential homing toward some types of brain lesion, but their migratory property during radiation injury (RBI) remains unexplored.
Meningioma-associated protein 30 (MAC30) is a vital modulator of malignant transformation in numerous cancers. Yet, the involvement MAC30 nasopharyngeal carcinoma (NPC) undetermined. This study was devoted to function NPC, along with molecular mechanism its disease progression. showed an elevated level NPC tissues and cell lines. silencing impeded proliferation, colony formation, invasion cells, while upregulation had opposite effects. regulated Wnt/β-catenin pathway via affecting kinase B...
<title>Abstract</title> Objective Colorectal cancer (CRC) is a common malignant tumor, and its prognosis closely associated with abnormalities in lipid metabolism; meanwhile, CT imaging-based radiomics also demonstrates significant advantages the evaluation of CRC. This study aims to investigate application value metabolism indicators deep learning models prognostic assessment colorectal cancer. Materials Methods We retrospectively collected clinical data, indicator imaging data patients...