A5059826577- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Vagus Nerve Stimulation Research
- Transcranial Magnetic Stimulation Studies
- Traditional Chinese Medicine Analysis
- Advanced MRI Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Studies
- Anesthesia and Neurotoxicity Research
- Neurological disorders and treatments
- Food Industry and Aquatic Biology
- Chemical and Physical Studies
- Neuroscience and Neural Engineering
Guangdong Polytechnic of Science and Technology
2024
Guangdong University of Technology
2021-2023
Third Affiliated Hospital of Southern Medical University
2022
Objective.Ultrasound neuromodulation has become an emerging method for the therapy of neurodegenerative and psychiatric diseases. The phased array ultrasonic transducer enables multi-target ultrasound in small animals, but relatively large size mass thick cables limit free movement animals. Furthermore, spatial interference may occur during brain stimulation with multiple micro transducers.Approach.In this study, we developed a miniature power used virtual source time inversion 3D printing...
Focused ultrasound neuromodulation (FUN) is widely regarded as a next-generation technology for neural modulation, with applications spanning rodents, non-human primates, and humans. While mechanistic studies are advancing, persistent confound-auditory interference-casts doubt on whether exerts direct mechanical effects or merely indirect auditory responses. To resolve this, we engineered circular transducer compatible two-photon calcium imaging examined its the primary visual cortex (V1) of...
Transcranial focused ultrasound (tFUS) is increasingly used in experimental neuroscience due to its neuromodulatory effectiveness animal studies. However, achieving multitarget tFUS small animals typically limited by transducer size, energy transfer efficiency, and brain volume. The objective of this work was construct an system for neuromodulation animals. First, a miniaturized high-powered 2-D array developed. phase delay each element calculated based on the multifocal time-reversal...
Transcranial ultrasound therapy has become a noninvasive method for treating neurological and psychiatric disorders, studies have further demonstrated that multitarget transcranial is better solution. At present, in small animals can only be achieved by the multitransducer or phased array. However, multiple transducers may cause spatial interference, array system complicated, expensive, especially unsuitable animals. This study first to design fabricate miniature acoustic holography lens...
Objective.Exhaustion of Serotonin (5-hydroxytryptamine, 5-HT) is a typical cause the depression disorder's development and progression, including depression-like behaviors. Transcranial ultrasound stimulation (TUS) an emerging non-invasive neuromodulation technique treating various neurodegenerative diseases. This study aims to investigate whether TUS ameliorates behaviors by restoring 5-HT levels.Methods.The model mice are established chronic restraint stress (CRS). Ultrasound waves (FF =...
Objective.Monoamine dysfunction has been implicated as a pathophysiological basis of several mental disorders, including anxiety and depression. Transcranial ultrasound stimulation (TUS) is noninvasive nerve technic showing great potential in treating depression/anxiety disorders. This study aims to investigate whether TUS can ameliorate depression with mice by regulating brain monoamine levels.Approach.Mice received repeated subcutaneous injections corticosterone (CORT, 20 mg kg-1) for 3...
Traditional Chinese medicine (TCM) is widely used in China, but the large variety can easily lead to difficulties visual identification. This study aims evaluate availability of target detection models identify TCMs. We have collected images 100 common TCMs pharmacies, and use three current mainstream models: Faster RCNN, SSD, YOLO v5 train TCM dataset. By comparing metrics models, results show that model has obvious advantages recognition a TCM, mean average accuracy 94.33% FPS reached 75,...
Ultrasound neuromodulation is a promising tool for depression disorder (DD) therapy. Research to date has focused on single-target stimulation such as prelimbic cortex (PrL) or dorsal raphe nucleus (DRN). However, the pathogenesis of DD involves multiple cerebral connected regions. A simultaneously simulating regions associated with pathology required allow more efficient treatment. In this study, we investigate antidepressant effect multi-target ultrasound PrL and DRN. The effects were...