A5009155077- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Inflammatory Bowel Disease
- Organ Transplantation Techniques and Outcomes
- Folate and B Vitamins Research
- Oral and gingival health research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Hip and Femur Fractures
- Neurological and metabolic disorders
- Circadian rhythm and melatonin
- HIV/AIDS drug development and treatment
Istanbul University-Cerrahpaşa
2001-2023
Istanbul University
2000-2015
Bezmiâlem Vakıf Üniversitesi
2015
University Gastroenterology
2010
Nightingale Hospital
2008
Marymount University
2008
Oxidative stress and insulin resistance (IR) are major contributors in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The purpose this study was to find relation between oxidative parameters histopathological findings NAFLD patients with without (IR).Thirty-two no alcohol intake biopsy-proven diagnosis were studied (M/F: 17/15; mean age 46.5±11.4 years). Twenty-one IR compared 11 IR. fasting level measured, index calculated using homeostasis model assessment (HOMA) method....
Abstract: Increased deposition of the extracellular matrix components, particularly collagen, is a central phenomenon in liver fibrosis. Stellate cells, mediators pathogenesis fibrosis are activated by free radicals, and synthesize collagen. Melatonin potent physiological scavenger hydroxyl radicals. has also been shown to be involved inhibitory regulation collagen content tissues. At present, no effective treatment available for clinical use. We aimed test effects melatonin on...
Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition associated with obesity and insulin resistance (IR). Leptin plays key role in the control of energy balance, sensitivity. In this study, we aimed to examine whether serum leptin levels correlate resistance, oxidative stress parameters severity histological changes NAFLD. Methods: Fifty-two patients (M/F: 28/24) no alcohol intake biopsy-proven diagnosis NAFLD were studied. Serum measured by radioimmunoassay. HOMA...
Abstract Background and Aim: Delta hepatitis is characterized by rapidly progressive liver disease with adverse prognosis in most patients. Patients benefit from high doses prolonged courses of interferon (IFN) therapy; however, lamivudine as a single agent has been disappointing. Data relating to the efficacy IFN combination limited. The aim this study was test IFN‐α 2b treatment comparison alone patients chronic delta hepatitis. Methods: Twenty‐six were randomized into two groups. Twelve...
Aim: To evaluate the serum alanine aminotransferase (ALT) variabilities in nonalcoholic fatty liver disease (NAFLD) and correlate it with hepatocyte apoptosis oxidative stress parameters. Methods: 24 patients NAFLD normal ALT were compared 26 subjects elevated ALT. Liver was estimated on basis of malondialdehyde, superoxide dismutase glutathione. Immunohistochemistry performed for activated caspase 3 8, nuclear factor-κB, antiapoptotic Bcl-2 protein TNF receptor levels measured. Results: The...
There is controversial data in the literature about characteristics or features of dual hepatitis B and C infection. Several studies have reported that infection has a more severe histological picture; faster progression leading to cirrhosis higher risk for hepatocellular carcinoma compared with single infections. These findings not yet been supported. We assessed patients respect their different our country. Method: chronic clinics were tested, both HBsAg anti-HCV positive enrolled study....
<i>Background:</i> Liver biopsy is an imperfect gold standard for assessing the disease severity in hemodialysis patients with chronic hepatitis C. Our purpose was to compare accuracy of FibroTest (FT) and ActiTest (AT) liver AST-to-platelet ratio index (APRI) determining hepatic fibrosis necroinflammatory activity C virus (HCV). <i>Methods:</i> The FT-AT combining 6 biochemical markers assessed 33 HCV. staged graded according METAVIR scoring system....
Hepatitis C virus (HCV) infection is endemic among hemodialysis (HD) patients. It well known that HCV causes approximately 50% of hepatosteatosis in patients with normal renal function and this rate higher infected genotype 3. The aim study was to investigate the steatosis, regression steatosis interferon (IFN) treatment factors affecting IFN chronic hepatitis (CHC).Thirty-seven HD CHC were included study. All received three times a week during follow-up period. Patients treated 3 million...
The efficacy of endoscopic ultrasound with fine-needle aspiration (EUS-FNA) in the diagnosis and staging pancreatic malignancy is quite well established. aim this study to describe a single-centre's experience.Data were collected retrospectively on all patients solid masses undergoing EUS-FNA from January 2006 March 2011. In tumor cases, TNM using EUS was compared results histopathological staging.EUS-FNA lesions performed 125 patients. Of these patients, data 75 available (69% men, mean age...
Objective In this study, we aimed to investigate the effects of direct antiviral treatment on depression, anxiety, fatigue and quality life in patients with chronic hepatitis C. Methods Subjects included study were experienced naive C admitted hepatology outpatient clinic between December 2016 June 2017. Before after treatment, Beck liver-specific severity-impact scales administered. Descriptive statistical methods, Kolmogorov-Smirnov distribution test Wilcoxon sign kappa coefficient tests...
Minimal hepatic encephalopathy can only be detected by specific psychometric or neuropsychological tests. We aimed to determine the prevalence of minimal in a hepatology outpatient clinic tertiary center.A total 82 patients with chronic liver disease were involved prospectively this study. Control groups consisted healthy volunteers (n = 123) and renal failure 28). used 2 different methods detect encephalopathy. First method was battery 5 tests (number connection A B, digit symbol test,...
Objective. To test the effects of peginterferon in an unrecoverable model bile-duct ligation (BDL) induced liver fibrosis. Material and methods.Thirty-seven Wistar rats were divided into five groups: group 1, BDL + (n = 8); 2, 3, sham 7); 4, 5, control 7). Peginterferon-alpha 2b (50 μgr/kg) or saline (1 mL/kg) was administered intraperitonealy every week for four weeks. Serum biochemical markers, tissue oxidative stress, collagen transforming growth factor-β (TGF-β) levels examined after...
We investigated the risk of abdominal operation in patients with fatty liver and any cancer first-degree relatives liver.We evaluated 105 nonalcoholic disease (NAFLD), 121 biopsy-proven hepatitis C (61 60 without liver), 50 inflammatory bowel (IBD), 109 dyspepsia.There was no difference sex, mean age, marital status among groups except that IBD were younger than others (p<0.001). The frequency family members 18% IBD, 9% dyspepsia, 28% steatosis, 21.5% 27% NAFLD (p=0.006). Then, we divided...
Several guidelines recommend the use of tenofovir or entecavir as first-line treatment for hepatitis B due to lower resistance rates these drugs than lamivudine, although lamivudine may still be preferred because its low adverse effect profile and cost. It is important know which patients might benefit from treatment. We aimed assess success entecavir, tenofovir, well rates, frequencies HBsAg clearance, risk factors resistance.A total 191 with chronic HBeAg-negative who were treated...