A5018718285- Inflammatory Bowel Disease
- Microscopic Colitis
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Pancreatitis Pathology and Treatment
- Hormonal Regulation and Hypertension
- Vaccine Coverage and Hesitancy
- COVID-19 Impact on Reproduction
- Renin-Angiotensin System Studies
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Inflammatory Myopathies and Dermatomyositis
- Diagnosis and treatment of tuberculosis
- Genetic factors in colorectal cancer
- Liver Diseases and Immunity
- Gastrointestinal Bleeding Diagnosis and Treatment
- Biomedical Research and Pathophysiology
- Hemophilia Treatment and Research
Istanbul University-Cerrahpaşa
2020-2025
Kartal Koşuyolu High Specialization Training and Research Hospital
2023-2025
Istanbul University
2012-2023
Gaziantep Children's Hospital
2019
Abstract Background Azathioprine (AZA)-associated acute pancreatitis (AP) and gastrointestinal intolerance (GI-INT) are common causes of AZA discontinuation in IBD patients1,2. This study compares HLA alleles linked to AZA-AP3,4, along with demographic clinical data, between AP GI-INT patients. Methods Data from five centers were used form three groups: Control (n=88), AZA-AP (n=44), (n=44). Patients diagnosed during treatment per the Atlanta criteria (radiology, elevated amylase/lipase,...
Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease with remissions and flares. Approximately 20% of UC Patients develop acute severe ulcerative (ASUC), serious condition that refractory to standard therapies leads morbidity mortality. Rescue therapy (salvage therapy) steroids, cyclosporine, and/or infliximab recommended by guidelines.1 The colectomy rate in ASUC remains at around 36% even the biological millennium.2 Upadacitinib (UPA) JAK1 selective inhibitor...
Abstract Background Radiological remission (RR), is the ultimate treatment goal in of complex perianal fistula (cPAF) Crohn’s disease (CD). In this study, we analysed cPAF characteristics and RR-related factors a CD cohort. Methods Patients with (1999–2023) MRI-confirmed (per AGA 2003 criteria, reviewed by 4 radiologists) were analyzed. Clinical (CR) was defined as no drainage under compression for ≥3 months, RR fibrotic closure. Results Among 1688 patients, PAF prevalence 24.7% (n=417), 19%...
Abstract Background Patient-reported outcome measures (PROMs) are used to assess the effectiveness of treatments received by patients in terms clinical response inflammatory bowel disease (IBD). We aimed evaluate perceived from patient’s perspective using PRO2, IBD Control Questionnaire (ICQ) and Visual Analogue Scale (VAS) at end induction therapy treated with upadacitinib. also correlation PROMs biochemical response. Methods included who underwent upadacitinib 01/07/2024 01/10/2024 ten...
Abstract Background Anti-TNF agents may show different response profiles when reintroduced after discontinuation due to nonresponse or allergy. This study aims evaluate and compare the efficacy side effect of anti-TNF in patients who underwent a re-switch. Methods A retrospective cohort 53 (41 treated with infliximab [IFX], 12 Adalimumab [ADA]) was analysed between 2005 2024. All had previously discontinued therapy, which later Premedication administered during re-switch for receiving...
Abstract Background Approximately half (10-40%) of the Inflammatory Bowel Disease (IBD) patients using Infliximab (IFX) develop secondary loss response due to drug levels falling below therapeutic range. This study aims identify levels, influencing factors and parameters that may be useful in predicting target levels. Methods The pre-infusion associated laboratory were evaluated IBD on maintenance dose IFX (5-15 mg/kg every 4-8 weeks) between Nov2021 - Oct2024. Drug measured a bedside kit...
Abstract Background Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the preferred surgical option for refractory ulcerative colitis (UC), dysplasia, or malignancy. De novo Crohn’s Disease (CD) a recognized postoperative complication that can occur in UC patients after IPAA. Pouchitis, common marked by nonspecific pouch inflammation, typically responds to antibiotics but progress proximal penetrating transmural later defined as de novo-CD. Methods This retrospective...
Abstract Background This study aimed to identify the risk factors for developing penetrating Crohn’s disease (CD) and evaluate clinical course of patients with CD at time diagnosis those who subsequently evolved during follow-up. Methods complications followed between 1986 2022 were retrospectively evaluated. Patients developed compared a control group did not. Also, on follow-up presenting diagnosis. Results From cohort 1,404 patients, identified in 312 (22.2%). A total 198 excluded due...
BACKGROUND:Renal involvement can complicate the course of inflammatory bowel disease (IBD). In this study, we aimed to analyze extent renal manifestations in patients with IBD (Crohn or ulcerative colitis) during biologic era. MATERIAL AND METHODS:Patients diagnosed and followed up for a period covering 16 years were retrospectively analyzed. Patients who received diagnosis clinical, endoscopic, histopathological findings older than 18 enrolled study. Demographic, laboratory, treatment data...
Malnutrition is related to increased morbidity, mortality, and costs. NRS-2002 a practical malnutrition risk (MR) screening tool approved by the European Society for Clinical Nutrition Metabolism (ESPEN) inpatients. We aimed reveal inpatient MR using NRS-2002, examine relationship between in-hospital mortality.The results of nutritional in tertiary referral center university hospital were retrospectively analyzed. The test was used defining MR. Comorbidities, initial follow-up anthropometric...
Most patients with ulcerative colitis (UC) active mucosal disease have a lower C-reactive protein (CRP) level than the classic accepted cutoff (≤5 mg/l). We aimed to predict remission in UC an optimal of CRP when activity and extensiveness were both considered.In this retrospective study, we evaluated values their relation extension 331 colonoscopic examinations performed between December 2016 March 2019. Endoscopic assessed using Mayo scores Montreal classification.The 2 3 groups'...
Introduction: Naples prognostic score (NPS) based on nutritional and inflammatory parameters can predict response to chemotherapy overall survival (OS) in many cancer types. However, its significance metastatic pancreatic (PC) remains unclear. We evaluated the of NPS patients with PC receiving first line chemotherapy. Methods: retrospectively analyzed 215 FOLFIRINOX NPS’s were calculated using pre-chemotherapy laboratory data. Patients divided into three groups according their scores (NPS:...
Aim: Vaccination against influenza, pneumococcal disease, herpes zoster and tetanus-diphtheria-acellular pertussis (Tdap) is recommended for older adults.Data on vaccination rates in adults are limited our country.We aimed to investigate the prevalence of community-dwelling adults. Methods:Patients >= 65 years admitted Dr. Ersin Arslan Research Training Hospital geriatric outpatient clinic between September 2017 May 2018 Gaziantep were included.Demographic data number medicines...
Abstract Background Inflammatory bowel disease (IBD), as a chronic inflammatory condition, can affect atherosclerotic process, arterial events, and increase the formation of venous thromboembolism. The aim this study was to determine frequency thromboembolism risk factors associated with acute in our IBD cohort. Methods A total 3133 patients 1414 Crohn's Disease (CD), 1667 Ulcerative Colitis (UC) 52 Indeterminate who were admitted between 1999 2021 retrospectively analyzed. Patients events...
Abstract Background Systemic steroid use, and IBD itself, both have negative effect on bone mineral density. Budesonide is a synthetic with high topical glucocorticoid activity low systemic bioavailability. When compared to steroids, the frequency of side effects budesonide appears be quite low, however, there no documented report about long term use BMD in patients. We also do not know other potential use. In this study, we aimed evaluate its’ effects, Methods retrospectively reviewed files...
Abstract Background Perianal fistula (PaF) is a debilitating and difficult to treat form of Crohn's disease. Although biological (anti-TNF) treatments are almost always used, long term closure rates far from being satisfactory. Radiological closure, which should be the treatment goal, even much rarer. Stoma one last steps in resistant fistula. In our study, we examined patients who underwent stoma, series, due PaF factors associated with radiological closure. Methods disease cohort was...
We have previously shown that CRP < 2.9 mg/L is a better predictor of endoscopic remission (ER) than 5 in ulcerative colitis (UC). Here, we prospectively evaluate and FCP cut-offs compare them predicting ER histological (HR) UC.