A5017545149- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiomyopathy and Myosin Studies
- Genetic Neurodegenerative Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Muscle Physiology and Disorders
- Lipoproteins and Cardiovascular Health
- Cellular transport and secretion
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Mycobacterium research and diagnosis
- Optimism, Hope, and Well-being
- Metabolism and Genetic Disorders
- Congenital heart defects research
- RNA Research and Splicing
- Health Promotion and Cardiovascular Prevention
- Health, Environment, Cognitive Aging
- Dermatoglyphics and Human Traits
- Infectious Diseases and Tuberculosis
- interferon and immune responses
Istanbul University
1998-2024
Institutt for Eksperimentell Medisinsk Forskning
2024
<b>Objective: </b> To assess the natural progression of muscle weakness in spinal muscular atrophy (SMA) IIIb. <b>Methods: Ten patients with SMA IIIb were followed for at least 10 years. Age disease onset varied between 9 and 18 Patients initially seen 2 to years after onset. They evaluated approximately 2, 5, 10, 15, 20 duration depending on timing their initial visit Medical Research Council (MRC) scale was used particular attention proximal muscles. <b>Results: The MRC grade declined all...
Apolipoprotein A5 (APOA5) gene polymorphisms are usually associated with plasma triglyceride levels. We evaluated the relationship of APOA5 -1131T>C and c.56C>G [single nucleotide polymorphism (SNP)] serum lipids, dyslipidemia [low high-density lipoprotein (HDL)/high triglyceride] risk for metabolic syndrome (MS) in Turkish Adult Risk Factor study.We genotyped SNPs using Taqman allelic discrimination assays 1564 adults (51.4% female, mean age 54.1+/-11.6 years). MS were defined criteria...
We aimed to evaluate the role of a synthetic somatostatin analogue in delay procedure experimental skin flaps. Thirty-six rats were randomly divided into 2 groups 18 each compare possible local ischemic effect octreotide with that surgical dorsal random pattern flap model. The inducible nitric oxide synthase gene expression was assessed territory at intervals immediate, 24 and 48 hours after preconditioning. Histologic analysis performed 48th hour 3 additional used for microangiography. A...
Antiviral drug resistance mutations at patients
Aim: In this study, the aim is to detect polymorphisms in gene encoding sodium taurocholate cotransporting polypeptide (NTCP), functional receptor for hepatitis B virus (HBV) and D virus. Materials Methods:The study included a total of 293 patients, with 150 diagnosed chronic HBV (CHB) 143 undergoing liver parenchyma biopsy procedures due different clinical indications.Total DNA was isolated from samples.The TaqMan SNP genotyping method used determine rs2296651 polymorphism SLC10A1 gene,...
Occult hepatitis B infection (OBI) is defined by the persistence of virus (HBV) genome in liver individuals testing negative for surface antigen (HBsAg). Hepatitis core antibody (anti-HBc) serological marker that indicates HBV exposure. The impact anti-HBc and OBI on patients with chronic C remains unclear. aim present study was to determine prevalence evaluate their clinical pathological outcomes C. included 59 HBsAg-negative who underwent a parenchymal biopsy. presence DNA investigated...
The purpose of this study was to evaluate the relationship IL28B rs12979860 and rs8099917 polymorphisms with clinical, histological, virological outcomes patients chronic hepatitis B (CHB) also treatment responses who received Nucleos(t)ide analogs (NAs) therapy.This included 152 CHB were underwent liver parenchymal biopsy. polymorphism genotyped using TaqMan assay.The CC TT identified as genotypes highest frequency in all patients. On other hand, GG lowest frequency. TG genotype...
Background Transthyretin-related familial amyloid polyneuropathy (TTR-FAP) is an autosomal dominant disorder caused by mutations of the transthyretin (TTR) gene. More than 100 different gene are identified worldwide, but still first described Val30Met most common one. The mutant amyloidogenic protein causes systemic accumulation fibrils that results in organ dysfunction and death. TTR-associated FAP a progressive fatal disease if left untreated should be considered differential diagnosis any...
OBJECTIVE: This study aims investigate genotypic and phenotypic presentation of Transthyretin-related familial amyloid polyneuropathy in Turkey BACKGROUND: (TTR-FAP) is an autosomal dominant disorder caused by mutations the transthyretin (TTR) gene. More than 100 different gene were identified worldwide, but still first described Val30Met most common one. The mutant amyloidogenic protein causes systemic accumulation fibrils that results organ dysfunction death. a progressive fatal disease if...
Amaç: Okült Hepatit B Virus (HBV) enfeksiyonu (Occult HBV infection; OBI) mevcut serolojik testler ile yüzey antijeni (Surface antigen; HBsAg) negatif tespit edilen bireylerin karaciğerinde genomunun uzun süreli persistan varlığı karakterizedir. Bu çalışmada OBI tanılı hastalardan elde HBV'lerin genotip, subgenotip ve subtip profillerinin karakteristiğinin irdelenmesi amaçlanmıştır. Gereç Yöntem: Çalışmaya HBsAg farklı klinik endikasyonlar nedeniyle karaciğer parankim biyopsisi...