A5057830009- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Economic and Financial Impacts of Cancer
- Breast Cancer Treatment Studies
- Renal cell carcinoma treatment
- Pharmaceutical studies and practices
- Lung Cancer Treatments and Mutations
- Biomedical Ethics and Regulation
- Global Health Care Issues
- Cancer Genomics and Diagnostics
- Innovation Policy and R&D
- Biosimilars and Bioanalytical Methods
- Cutaneous lymphoproliferative disorders research
- Cancer Treatment and Pharmacology
- Treatment of Major Depression
- Pancreatic and Hepatic Oncology Research
- Dermatology and Skin Diseases
- Multiple and Secondary Primary Cancers
- Intraocular Surgery and Lenses
- Lung Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Cancer-related Molecular Pathways
- Statistical Methods in Clinical Trials
- Cystic Fibrosis Research Advances
- Cancer, Lipids, and Metabolism
Sanofi (France)
2024
Université de Rouen Normandie
2023
Centre Hospitalier Universitaire de Rouen
2023
Creativ-Ceutical (France)
2011-2018
Ipsen (France)
2017-2018
Health Economics and Outcomes Research (United Kingdom)
2016
Université Claude Bernard Lyon 1
2014-2015
Institut Gustave Roussy
2007-2014
Adjuvant cisplatin-based chemotherapy only marginally improves survival in patients with completely resected non-small-cell lung cancer (NSCLC). We have evaluated the predictive value of mutations TP53, encoding tumour suppressor p53, International Lung Cancer Trial (IALT), a randomized trial adjuvant against observation. TP53 (exons 4-8) was sequenced 524 archived specimens IALT median follow-up 7.5 years. Predictive analyses were based on Cox models adjusted for clinical and pathological...
Our purpose was to compare the sensitivity of whole body (WB) magnetic resonance imaging (MRI) and somatostatin receptor scintigraphy (SRS) for diagnosis bone metastases (BMs) in patients with well-differentiated gastro-entero-pancreatic endocrine cancer (WD-GEP-EC) determine predictive factors BM.WB-MRI SRS were prospectively performed 79 bronchial (11), thymic (five), gastric (two), duodeno-pancreatic (24), ileal (26), colic (one), or unknown primary (10) WD-GEP-EC.A total 36 (46%) had 333...
Background and Aims The heterogeneous nature of breast cancer can make decisions on adjuvant chemotherapy following surgical resection challenging. Oncotype DX is a validated gene expression profiling test that predicts the likelihood benefit in early-stage cancer. aim this study to determine costs private hospitals France, evaluate cost-effectiveness from national insurance societal perspectives. Methods A multicenter was conducted seven French hospitals, capturing retrospective data 106...
Purpose: The aim of this study was to compare the cost-effectiveness cabozantinib with standard care in England adult patients advanced renal cell carcinoma (aRCC), following prior vascular endothelial growth factor receptor (VEGFR)-targeted therapy. Methods: We developed a partitioned-survival model three health states assess and its comparators. time horizon 30 years. Efficacy safety data were derived from pivotal clinical trials (METEOR: NCT01865747, CheckMate025: NCT01668784, AXIS:...
Abstract Purpose To assess real-world treatment patterns in patients diagnosed with hormone receptor positive (HR+), human epidermal growth factor 2 negative (HER2-) metastatic breast cancer (mBC) who received cyclin-dependent kinase 4/6 (CDK4/6) inhibitors combination an aromatase inhibitor (AI) or fulvestrant at first line. Methods Patient characteristics, history, and outcomes data were extracted from the French ‘Système National des Données de Santé’ (SNDS) database for HR+/HER2- mBC...
The introduction of the orphan drug legislation led to increase in number available drugs, but access them is often limited due high price. Social preferences regarding funding drugs as well criteria taken into consideration while setting price remain unclear. study aimed at identifying determinant prices France using a regression analysis. All with valid designation moment launch for which was were included selection covariates based on literature review and characteristics (Anatomical...
Objectives:There is a paucity of recent data on breast cancer costs, particularly the burden chemotherapy. The present study was designed to estimate resource use and costs associated with current standard care for adjuvant chemotherapy cancer.Methods:Costs were assessed by retrospective analysis medical records at single comprehensive center, Hôpital Tenon, Paris, France. Data extracted from files female patients having undergone surgical resection between January–July 2010. Patients...
With constant incentives for healthcare payers to contain their pharmaceutical budgets, forecasting has become critically important. Some countries have, instance, developed horizon scanning units. The objective of this project was build a model assess the net effect entrance new patented medicinal products versus going off-patent, with defined forecast horizon, on selected European Union (EU) Member States' budgets. This took into account population ageing, as well current and future...
Sialolithiasis, or salivary stones, is not a rare disease of the major glands. However, aetiology and incidence remain largely unknown. Since sialoliths are comprised mainly calcium phosphate salts, we hypothesise that drinking water levels other elements in could play role sialolithiasis. Owing to substantial intermunicipality differences composition, Denmark constitutes unique environment for testing such relations.
During cataract surgery, maintaining an adequate degree of mydriasis throughout the entire operation is critical to allow for visualisation capsulorhexis and crystalline lens. Good anaesthesia also essential safe intraocular surgery. Mydrane® a new injectable intracameral solution containing two mydriatics (tropicamide 0.02% phenylephrine 0.31%) one anaesthetic (lidocaine 1%) that was developed as alternative conventional topical pre-operative used in This study aimed estimate budget impact...
The value appreciation of new drugs across countries today features a disruption that is making the historical data are used for forecasting pharmaceutical expenditure poorly reliable. Forecasting methods rarely addressed uncertainty. objective this project was to propose methodology perform integrates expected policy changes and uncertainty (developed European Commission as 'EU Pharmaceutical forecast'; see http://ec.europa.eu/health/healthcare/key_documents/index_en.htm).1) Identification...
With constant incentives for healthcare payers to contain their pharmaceutical budgets, modelling policy decision impact became critical. The objective of this project was test the various decisions on budget (developed European Commission 'European Union (EU) Pharmaceutical expenditure forecast' - http://ec.europa.eu/health/healthcare/key_documents/index_en.htm).A model built assess scenarios' budgets seven member states EU, namely France, Germany, Greece, Hungary, Poland, Portugal, and...
Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) associated patient caregiver productivity loss Japan.Methods: This study compared current care (estimated at 53.8% utilization anti-VEGF using data) that hypothetical (characterized by a higher [80.0%], as estimated an expert panel) DME patients. A population-based Markov model (two-eye approach) simulated acuity (Early...
10010 Background: In a prior randomized phase II trial comparing hyperthermic isolated limb perfusion (HILP) with melphalan and 4 different doses of TNFa (0.5 mg; 1 2mg, 3 mg/4mg superior/ inferior limb), there was no dose effect detected for the tumour response but systemic toxicity significantly lower low TNF-a (Bonvalot S et al. 2005). The objective present study to confirm these datas on larger population locally advanced or recurrent STS extremity using TNFa. Methods: Prospective...
7506 Background: The IALT and JBR.10 randomized trials both demonstrated the survival advantage of adjuvant platinum-based CT for patients with resected NSCLC. We previously showed by immunohistochemistry (IHC) that high TUBB3 expression might correlate greater benefit from vinorelbine/cisplatin in an analysis tumor tissues 265 trial. Here, we sought to verify previous suggestions Since some regimens trial did not include anti-tubulin agent, also tested hypothesis value predicting was...
Background: To date, no specific instruments exist to measure the quality of patient-surgeon relationship despite its potential influence clinical and economic outcomes in patients undergoing surgery for musculoskeletal disorders (MSDs). Objective: The objective was develop validate an instrument assess relationship, taking into account return work after functional restoration surgery. Methods: development based on literature review, cognitive interviews expert examinations. instrument's...