A5056815789- Neurobiology and Insect Physiology Research
- Aluminum toxicity and tolerance in plants and animals
- Heavy Metal Exposure and Toxicity
- Essential Oils and Antimicrobial Activity
- Cholinesterase and Neurodegenerative Diseases
- Piperaceae Chemical and Biological Studies
- Drug-Induced Hepatotoxicity and Protection
- Malaria Research and Control
- Aldose Reductase and Taurine
- Stress Responses and Cortisol
- Insect Utilization and Effects
- Natural Antidiabetic Agents Studies
- Bee Products Chemical Analysis
- Ethnobotanical and Medicinal Plants Studies
- Cardiac Health and Mental Health
- Phytochemistry Medicinal Plant Applications
- Healthcare professionals’ stress and burnout
- Health and Well-being Studies
- Visual and Cognitive Learning Processes
- Biochemical effects in animals
- Pesticide Exposure and Toxicity
- Curcumin's Biomedical Applications
- Regulation of Appetite and Obesity
- Mangiferin and Mango Extracts
- Medicinal Plants and Neuroprotection
University of Zambia
2023
Kampala International University
2018-2022
Western International University
2021
Aluminium is known to accelerate oxidative stress, amyloid beta (Aβ) deposition, and plaque formation in the brain of rats. Objective. The present study aimed at studying neuroprotective effects eugenol following aluminium-induced neurotoxicity on caspase-3, apoptotic proteins (Bcl-2 Bax), stress markers Wistar rats such as superoxide dismutase (SOD), glutathione peroxidase (GPx), nitric oxide (NO), assay mitochondrial DNA (mtDNA) by measuring levels 8-hydroxy-2-deoxyguanosine (8-OHdG)....
Background . There is scarcity of information about the quality and safety drinking water in Africa. Without such vital information, sustainable development goal number 6 which promotes availability management sanitation remains elusive especially developing countries. The study aimed at determining concentrations inorganic compounds, estimated daily intake (EDI), target hazard quotient (THQ), index (HI), incremental lifetime cancer risk (ILCR), identify safe source sources Southwestern...
Background: Reaction time (RT) is an indicator of neural activity, however, its variation due to visual (VRT), audio (ART) and tactile (TRT) in African medical students has not been investigated. The aim the study was determine relationships between VRT, ART TRT amongst Uganda.Materials methods: This a cross sectional study, body mass index (BMI) RT (i.e. TRT) were determined using weighing scale with standiometer catch ruler experiment respectively. A questionnaire administered collect...
Monosodium glutamate (MSG) has been marred by a lot of controversy on its safety. In majority experimental studies, administration the compound parenteral, and yet little is known about MSG safety consumed as food supplement. this study, we assessed effects low concentrations activity hydrogen scavenging, catalase climbing well lifespan in male Drosophila melanogaster over 30 days period since sparsely studied.No significant differences were associated with at 5%, 1%, 0.2%, 0.04% peroxide...
Donepezil is the most common drug used in treatment of disorders associated with memory loss, especially that Alzheimer's disease. Healthy individuals however have continued to use it as a enhancer. This study was aimed at evaluating combined therapy donepezil and propolis on cognition Drosophila melanogaster. Method. melanogaster flies were divided into five groups fed different doses ethanolic extract follows: normal food, 250 mg/mL, 50 0.001M, 0.001M/propolis mg/mL added their food. The...
Abstract Objective Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies gastric mucosa is scarce. The aim this study was to investigate effects Artesunate-Amodiaquine and Artemether-Lumefantrine ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) major histological changes in male Wistar rats following induction using Indomethacin were investigated. Gastric ulcers four groups; Group I...
Abstract Background The Phosphatase and tensin-induced putative kinase 1 (PINK1 B9 ) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism its possible remedy. This research was targeted toward determining effects ethanolic extract propolis, with levodopa therapy management Parkinsonism. Method PINK1 flies were divided into groups fed different treatment doses ethanoic propolis. subjected to 21 days administration propolis at after...
Stress among medical students is related to their academic lifespan; however, information on brain health from developing countries continues be scarce. The objective of this study was establish perceived stress levels, assess the ability cope with stress, and investigate its effects visual reaction time (VRT), audio (ART), tactile (TRT) in somatosensory cortex Uganda.This a cross-sectional conducted preclinical (n = 88) clinical 96) undergraduate at Kampala International University Western...
Diabetes mellitus has not ceased to be on rise in spite of the continuous research its management. Brain dysfunction associated with especially Type II been great concern. The aim this study was investigate effect insulin sensitizing drug metformin and ethanolic extract garlic membrane bound enzymes Na+/K+ ATPase, Ca2+ ATPase glutamate-glutamine cycle enzyme, Glutamine Synthetase activities hippocampus streptozotocin-Nicotinamide induced Diabetic rats. Twenty four male wistar rats weighted...
Objectives Calcium deregulation in diabetes mellitus (DM) is central to the brain-heart axis pathology. This has led use of medical plants complementary medicine such as Amaranthus hypochondriacus (GA). The objective study was establish effects grain amaranth feed supplementation on calcium, s100al protein and antioxidant levels diabetic male Wistar rats. Methods involved six groups (n=5) with DM being induced 20 To rats, Group I received mixtard®, II positive control, Groups III IV GA at 25...
Abstract Objective: Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies gastric mucosa is scarce. The aim study was to establish effects Artesunate-Amodiaquine and Artemether-Lumefantrine ulcers, malondialdehyde (MDA), reduced glutathione (GSH) identify major histological changes in male Wistar rats. Gastric ulcers were induced using Indomethacin four groups group 1 administered Artesunate, 2 received...
Stress is an integral part of human life; stressful events exert deleterious effects on normal (physiological) functions, leading to the pathogenesis diseases. alters cognition, learning, memory and emotional responses, resulting in mental disorders like depression anxiety. The comparative effect taurine (TAU) vitamin E (VIT E) was evaluated learning acetaminophen-induced oxidative stress male Wistar rats. Methods Twenty animals weighing (100-120 g) were divided into four groups (A-D) five...
Aluminium and its compounds when taken orally can have negative impacts on a variety of enzymes leading to neurotoxicity. Apurinic endonuclease 1 (APE-1), protein that performs multiple functions, including deoxyribonucleic acid (DNA) repair, is essential for cell survival. Thus, the determination APE-1 with aluminium chloride (AlCl3) induced neuro-inflammation in Wistar rats was performed this study. were divided into four groups, each six animals. Group received 100 mg/kg AlCl3 orally, 2...
The present study was carried out to the effects of Eugenol on Brain neurotrace elements (Iron Fe; Manganese Mn: Magnesium Mg) following administration Aluminium chloride Wistar rats.Materials and Methods.Thirty (30) adult rats were randomly divided into six (6) groups namely: •Group I: Rats receiving 300 mg/kg for 21 days,• Group II: 150 eugenol III: 100 IV: V: aluminium days • VI: 2ml distil water as placebo respectively.The sacrificed 24 hours after last dose by 0.8ml ketamine an...
Abstract Background Depression is a serious mental health problem in different parts of the world and has been reported to be rising among undergraduate medical students. The incidence depression not only linked psychosocial factors but also biological factors, such as altered urinary levels norepinephrine. This study was carried out determine prevalence students Uganda examine relationship between depressive symptoms 24-hour norepinephrine excretion participants. Methods One hundred sixteen...
Abstract Objective Challenges associated with current nutritional models to induce obesity in Drosophila melanogaster created a rationale for this study. The objective of the study was investigate biochemical changes high-fat diet (HFD), high sucrose (HSD), and protein-restricted (DR) healthy metabolic state. were fed four experimental diets: regular food (control), HFD, HSD, DR, weeks. Peristaltic waves measured on 3 rd instar larvae, while negative geotaxis, body mass, catalase activity;...