A5033984580- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Salmonella and Campylobacter epidemiology
- Bacterial Identification and Susceptibility Testing
- Identification and Quantification in Food
- Infection Control in Healthcare
- Food Safety and Hygiene
- Mosquito-borne diseases and control
- Brucella: diagnosis, epidemiology, treatment
- Viral Infections and Vectors
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS drug development and treatment
- Bacterial biofilms and quorum sensing
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Mycotoxins in Agriculture and Food
- Livestock and Poultry Management
- Antibiotics Pharmacokinetics and Efficacy
- Burkholderia infections and melioidosis
- Nosocomial Infections in ICU
- COVID-19 impact on air quality
- Patient Satisfaction in Healthcare
University of Zambia
2021-2025
Antimicrobial resistance (AMR) is a global public health crisis. This study assessed the general public's consumption of antibiotics and associated factors in Lusaka district Zambia.
Antimicrobial resistance (AMR) is a global public health problem affecting animal and human medicine. Poultry production among the primary sources of income for many Zambians. However, increased demand poultry products has led to subsequent increase in antimicrobial use. This study assessed awareness AMR associated factors layer farmers Zambia. A cross-sectional was conducted 77 participants from September 2020 April 2021. Data analysed using Stata version 16.1. The overall 47% (n = 36)....
Globally, the inappropriate dispensing and use of antibiotics in animals has contributed to development bacterial antimicrobial resistance (AMR). In Zambia, there is insufficient information among community pharmacy professionals on antibiotic (ABU) AMR food-producing animals. This study assessed professionals' knowledge, attitudes, practices regarding poultry dispensing, use, Lusaka district Zambia. A cross-sectional was conducted 178 between February April 2022 using a semi-structured...
The challenges posed by antibiotic-resistant pathogens have continued to increase worldwide, particularly in resource-limited countries. Human-livestock interactions are implicated the complex AMR causal web. A cross-sectional study was conducted four districts of Lusaka Province, Zambia determine antibiotic resistance patterns, ESBL production E. coli isolated from stool samples broiler poultry farm workers, and assess farmers' awareness. Sixty-six human were collected processed for...
Antimicrobial resistance (AMR) is a global public health problem that fuelled by the inappropriate prescribing of antibiotics, especially those from 'watch' and 'reserve' antibiotic lists. The irrational antibiotics particularly prevalent in developing countries, including Zambia. Consequently, there need to better understand patterns across sectors Zambia as basis for future interventions. This study evaluated using WHO indicators alongside 'access, watch reserve' (AWaRe) classification...
Abstract Background Antimicrobial resistance (AMR) of pathogens such as Pseudomonas aeruginosa is among the top 10 threats to global health. However, clinical and molecular data are scarce in Zambia. We, therefore, evaluated AMR profiles P. nosocomial infections (NIs). Methods A year-long hospital-based cross-sectional study was conducted at two large tertiary-level hospitals Patients with current or previous hospital contact were screened for NIs. The focused on patients diagnosed Clinical...
The inappropriate prescribing and use of antibiotics have contributed to the emergence spread antimicrobial resistance (AMR). In Zambia, there is a paucity information on patterns among hospitalized patients in level 1 hospitals. This study investigated antibiotic five hospitals Lusaka, Zambia. cross-sectional utilized World Health Organization (WHO) Point Prevalence Survey (PPS) methodology in-patients admitted before 08:00 a.m. survey day August 2024. Data were analysed using IBM SPSS...
Increased antimicrobial resistance (AMR) has been reported for pathogenic and commensal
Background: Antimicrobial resistance (AMR) is a global public health problem affecting healthcare systems. There little information on undergraduate pharmacy students' knowledge, attitude, and practices regarding antibiotic use (AMU) AMR in Zambia. This study assessed AMU among students at the University of Materials Methods: cross-sectional was conducted among172 randomly selected participants using structured questionnaire. Data were analysed IBM Statistical Package for Social Sciences...
The use of antimicrobials in layer poultry production for improved production, growth promotion, prophylaxis and treatment purposes has contributed to the development antimicrobial resistance (AMR) poultry. In Zambia, there is a paucity information on prevalence AMR patterns Enterococcus species isolated from laying hens.This study investigated enterococci hens Lusaka Copperbelt provinces Zambia.A cross-sectional was conducted September 2020 April 2021. Three hundred sixty-five pooled...
Inappropriate use of antimicrobials exacerbates antimicrobial resistance (AMR) in the poultry sector. Information on factors driving AMR layer sector is scarce Zambia. This study examined drivers Lusaka and Copperbelt Provinces Zambia.This cross-sectional employed a structured questionnaire 77 farms provinces Copperbelt, Zambia, from September 2020 to April 2021. Data analysis was conducted using Stata version 16.1. Antimicrobial defined as presence multidrug (MDR) isolates. Multivariable...
L. monocytogenes is a public health threat linked to fast foods such as broiler chickens. This study aimed verify the occurrence of Listeria species in chickens from abattoirs and evaluate their antimicrobial resistance. In total, 150 carcass swabs distributed cloacal (n = 60), exterior surface environmental 30) were collected. characterized using biochemical tests PCR. We conducted antibiotic resistance disc diffusion Etest (Biomerieux, Durham, NC, USA) methods. Overall isolation was 15%...
Objective: Salmonella species and Escherichia coli are major bacterial enteropathogens of worldwide public health importance that cause devastating foodborne diseases, thereby contributing to increased human morbidity mortality. Both pathogens have also been found contribute towards the spread antimicrobial resistance through food chain, especially in poultry. This study aimed determine occurrence antibiotic-resistant spp. E. broiler chickens at farm level, abattoirs, open markets selected...
Aflatoxins B1 (AFB1) are fungi-produced toxins found in crops like peanuts, maize, and tree nuts. They constitute a public health concern due to their genotoxic carcinogenic effects. A deterministic exposure risk assessment AFB1 through the consumption of peanuts was conducted on children using Margin Exposure (MOE) liver cancer approaches. Data concentrations quantities peanut consumption, weights were obtained from literature. Generally, MOE values below safe margin 10,000, ranging between...
Antimicrobial resistance (AMR) of foodborne pathogens is public health concern, especially in developing countries such as Zambia. This study was undertaken to determine the antimicrobial profiles Escherichia coli (E. coli) and Salmonella isolated from retail broiler chicken carcasses purchased open markets supermarkets A total 189 E. five isolates were isolated. Identification confirmation done using Analytical Profile Index (API 20E) (Biomerieux®) 16S rRNA sequencing. susceptibility tests...
Nosocomial infections are a serious public health problem affecting both developed and developing countries. They caused mainly by multi-drug-resistant pathogens that limit treatment options, leading to high morbidity mortality, longer hospital stays increased costs of care. This study aimed evaluate nosocomial infections, risk factors causative at two large teaching hospitals in Zambia. A yearlong hospital-based cross-sectional was conducted from April 2020 2021 tertiary-level Hospitalised...
The circulation of both West Nile Virus (WNV) and Chikungunya (CHIKV) in humans animals, coupled with a favorable tropical climate for mosquito proliferation Zambia, call the need better understanding ecological epidemiological factors that govern their transmission dynamics this region. This study aimed to examine contribution climatic variables distribution
Abstract Salmonella species and Escherichia coli are major bacterial enteropathogens of global public health importance that cause foodborne diseases, thereby contributing to increased human morbidity mortality. Both pathogens have also been found contribute towards the spread antimicrobial resistance through food chain, especially in poultry. The aim this study was determine occurrence antibiotic-resistant sp . E. broiler chickens at farm level, abattoirs open markets selected districts...
Background: Brucellosis is a neglected debilitating zoonosis widely recognized as an occupational health hazard. The seroprevalence of human anti- Brucella antibodies in high-risk populations, well their risk factors, have not been well-documented Zambia. This study aimed at estimating the herdsmen and abattoir workers assess associated factors. Methods: A cross-sectional seroepidemiological was carried out between May December 2020 among Namwala, Monze Choma districts Southern Province...
Background: Staphylococcus aureus and Enterococcus species cause invasive infections such as bacteremia infective endocarditis. Despite vancomycin being the drug of choice for drug-resistant caused by these species, few studies have been conducted to ascertain resistance in African setting. This is crucial given rising organisms. study aimed isolate S. determine their susceptibility other antibiotics at University Teaching Hospitals Lusaka, Zambia. Methods: was a cross-sectional which spp...
ABSTRACT Introduction Brucellosis is a neglected zoonotic disease that affects humans and animals can lead to severe illness in financial losses for households rear livestock. The study aimed investigate the seroprevalence of human Brucella antibodies associated risk factors among patients seeking medical attention at community hospitals. Methods A cross-sectional seroepidemiological was conducted from 21 st April 2021 2024 hospitals selected districts Western province Zambia. 225 blood...
A cross-sectional study was conducted in five districts of Zambia. The aimed to investigate the risk factors associated with antimicrobial resistance (AMR) broiler chickens total 109 farms were included study, which 104 small-scale farms, two medium-scale, and three commercial-scale. semi-structured questionnaire administered alongside collection cloacal swabs litter samples determine occurrence AMR food pathogen microorganisms on selected farms. Data collected analysed using STATA version...
Aluminium and its compounds when taken orally can have negative impacts on a variety of enzymes leading to neurotoxicity. Apurinic endonuclease 1 (APE-1), protein that performs multiple functions, including deoxyribonucleic acid (DNA) repair, is essential for cell survival. Thus, the determination APE-1 with aluminium chloride (AlCl3) induced neuro-inflammation in Wistar rats was performed this study. were divided into four groups, each six animals. Group received 100 mg/kg AlCl3 orally, 2...