A5018979838- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Estrogen and related hormone effects
- Pharmaceutical Practices and Patient Outcomes
- Reproductive tract infections research
- Prostate Cancer Treatment and Research
- Nanoparticle-Based Drug Delivery
- Bone health and osteoporosis research
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Pharmaceutical Economics and Policy
- Syphilis Diagnosis and Treatment
- RNA modifications and cancer
- HIV, Drug Use, Sexual Risk
- Global Maternal and Child Health
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Antibiotic Use and Resistance
- Bone Metabolism and Diseases
- Cancer Research and Treatments
- Testicular diseases and treatments
- Steroid Chemistry and Biochemistry
University of Zambia
2011-2022
International Pharmaceutical Federation
2020
University College London
2020
Institute of Economic Research Foundation
2020
Numerous reviews on starch biosynthesis and degradation have appeared inthe 1980s (4, 23, 39, 40, 51, 73, 100, 101, 124, 125). Here we updateestablished concepts emphasize three topics that consider to now meritreexamination: the significance of enzyme multiplicity, a comparison ofdegradation reserve transitory starch, localization starchdegrading enzymes in starch-free cellular compartments leaf tissues. Westress cell physiological aspects metabolizing enzymes.
Vaginal microbicides are in development for the prevention of HIV transmission to women via sexual intercourse. Acceptability microbicide delivery method targeted population is important product adherence and, therefore, effectiveness. It anticipated that multiple methods will be required satisfy personal preferences among future users.A total 526 sexually active aged 18-30 years participated a consumer preference study Burkina Faso, Tanzania, and Zambia. Screened who had given consent were...
Background: Antimicrobial/Antibiotic Resistance (AMR) is among the major threats to global health. Due limited information on subject matter in Zambia, we assessed knowledge, attitude, and practices of community pharmacists AMR Antimicrobial Stewardship (AMS). Materials Methods: We conducted a descriptive cross-sectional study 144 randomly selected through structured questionnaire. Data were analysed using Statistical Package for Social Sciences version 22 at 95% confidence level. The...
Background: Antimicrobial resistance (AMR) is a global public health problem affecting healthcare systems. There little information on undergraduate pharmacy students' knowledge, attitude, and practices regarding antibiotic use (AMU) AMR in Zambia. This study assessed AMU among students at the University of Materials Methods: cross-sectional was conducted among172 randomly selected participants using structured questionnaire. Data were analysed IBM Statistical Package for Social Sciences...
Background: The novel coronavirus disease (COVID-19) is a serious global health problem that has negatively impacted the mental of students.Methods: We conducted an online descriptive cross-sectional study among 273 undergraduate pharmacy students at University Zambia from August to September 2020. A partial proportional odds regression model was used determine predictors anxiety. All statistical tests were set 95% confidence level (p<0.05).Results: response rate 70% obtained with...
Mesothelin (MSLN) is a glycophosphatidylinositol(GPI)‑linked cell surface protein that highly expressedin several types of malignant tumor, including malignantpleural mesothelioma, ovarian cancer and pancreaticadenocarcinoma. Recently, comprehensive immunohistochemicalstudy using MN‑1 monoclonal antibody identifieda significant number colorectal tumors in which MSLNwas expressed. However, the clinicopathological profiles andsurvival patients with MSLN‑positive cancerhave not been fully...
Background: In 2015, Zambia reported 218,200 instances of Diabetes Mellitus (DM) with 8,232 diabetes-related fatalities. Insulin therapy and oral antidiabetic medications are two pharmacological therapies used to treat diabetes mellitus. Herbal medicine, on the other hand, has a lengthy history is an easily accessible economical therapeutic option. Patients Type 2 (T2DM) increasingly turning herbal as keeping conventional regimens becomes more challenging. Aim: We aimed assess prevalence...
The incidence of HIV-associated Kaposi's sarcoma (KS) remains high in Zambia the antiretroviral therapy era. most efficacious treatment regimen for KS has yet to be established. In both developed and developing countries, regimens have had limited efficacy. Late presentation Africa affects therapeutic outcomes.
Abstract Antibiotic resistance is among the major threats to global health. Due limited information on subject matter in Zambia, we assessed knowledge, attitude, and practices of community pharmacists antibiotic antimicrobial stewardship. We conducted a descriptive cross-sectional study 144 randomly selected through structured questionnaire. Data were analysed using Statistical Package for Social Sciences version 22 at 95% confidence level. A response rate 91% (n=144) was achieved. The...
Background: Despite continuing professional development (CPD) becoming a key strategy for improving health outcomes by enhancing the quality of pharmaceutical care services, CPD needs practitioners in Zambia remained unknown prior to this study. Aim: To determine and preferences among Zambia. Methods: This descriptive cross-sectional study involved administering structured self-administered online questionnaire collect data from 111 registered Results: The majority participants (80%) were...
Ocimum americanum L. is an annual herbaceous plant used to manage pain and inflammation. Lack of standard dosage forms, safety efficacy data potentially exposes users this medicinal the risk toxic or sub-therapeutic effects, as well drug-herb interactions. The study developed a form containing O. extract assessed its anti-inflammatory stability. fusion method was formulate ointment comprising acetone extract, beeswax, soft-paraffin. Formulation optimization involved application Box-Behnken...
Several studies have shown antitumor activities of themelanoma differentiation–associated gene 7 (mda-7) andthe nonsteroidal anti-inflammatory drug sulindac whenused as a monotherapies against wide variety humancancers. However, the combined effects mda-7 andsulindac not previously been tested. Therefore, wetested activity an adenoviral vectorexpressing (Ad-mda7) in combination with sulindacagainst non–small cell lung cancer cells vitro andin vivo. When treated Ad-mda7 withsulindac, human...
We evaluated the in vitro availability and its stability under simulated tropical conditions of variousformulations four essential drugs marketed Tanzania. obtained 22 formulations (containingparacetamol, acetylsalicylic acid, chloroquine or sulphadoxine/pyrimethamine) from wholesalepharmacies Dar es Salaam Medical Stores Department (Tanzania). The drug content, vitroavailability (dissolution) were determined usingmethods specified United States Pharmacopoeia (USP) 24 monograph respective...
A simple Google search using the phrase ‘TheFoundational Philosophy of Medicine’ yields 1,510,000results. If one omits word ‘Foundational’, then thesearch result 11,900,000 items. Certainly, muchmaterial varying scholarship and complexity has beenwritten over course two millennia on this veryparticular subject, not all which is immediatelyaccessible, even through Google. Yet fundamentalphilosophy medicine can also be articulated very simplyand indeed been in following few words: ‘tocure...
Enchondromas are benign cartilage tumors and precursors tomalignant chondrosarcomas. Somatic mutations in the isocitratedehydrogenase genes (IDH1 IDH2) present majorityof these tumor types. How cause enchondromasis unclear. Here, we identified spectrum of IDH inhuman enchondromas chondrosarcomas studied theireffects mice. A broad range was identified, includingthe previously unreported IDH1-R132Q mutation. These mutationsharbored enzymatic activity to catalyze α-ketoglutarate...
The coronavirus disease 2019 (COVID-19) has caused many global challenges, especially in resource-constrained countries. Africa, a continent with large number of low-and middle-income countries (LMICs), shares this burden disproportionately compared to developed Here we review some the major challenges African face fight against COVID-19 and propose mitigation measures. Studies have reported low adherence prevention measures most Additionally, there been shortage healthcare workers,...
The International Pharmaceutical Federation (FIP) hosted the first Global Conference on Pharmacy and SciencesEducation in Nanjing, China, 7 &amp; 8 November 2016. global conference was an exceptional event that gathered pharmacyleaders from around world to create a globally shared vision for transformative pharmacy pharmaceutical scienceseducation.Following extensive consensus-based consultation process, three critical documents set future milestones forworkforce development through...
TRIM44 has oncogenic roles in various cancers. However, expression andits function renal cell carcinoma (RCC) are still unknown. Here this study, weinvestigated the clinical significance of and its biological RCC.TRIM44 overexpression was significantly associated with M stage, histologictype (clear cell) presence lymphatic invasion (P = .047, P .005, .028,respectively). Moreover, withpoor prognosis terms cancer-specific survival .019). Gain-of-function andloss-of-function studies using...
Adherence is one of the most crucial determinants treatment response toantiretroviral therapy (ART). An analytical cross-sectional study was conducted in24 Care and Treatment Centres (CTC) in Dar es Salaam Iringa regions inTanzania. Data collected using questionnaire appointments records. A totalof 943 patients attending at care sites Iringawere recruited. based on keeping four days recallwas 65% 70%, respectively. taking ART more than 95% ofthe time month 83%. Satisfaction with health...
Background: The irrational use of drugs remains a keyhealth problem in many developing countries. Theprevalence drug and factors associatedwith it were investigated at Kapiri Mposhi DistrictHospital Zambia.Methods: outpatient records (n = 680) clinicalencounters from the hospital registry department for theyear 2010 analysed. selection process adapted arandom sampling method using patient logbook inorder to get representative sample. Standardised WorldHealth Organization (WHO) prescribing...
Abstract Objectives The objective of this study was to update the self-assessment tool and evaluate current hospital pharmacy practices in six sub-Saharan African countries. Methods Questions validated survey were edited if revised Basel Statement changed intent. A total 13 updates made. administered via e-mail personnel any centre Ghana (258 hospitals), Nigeria (17 038 Malawi (499 Uganda (155 Zambia (98 hospitals) Zimbabwe (1389 hospitals). Snowball sampling increased reach across each...
BackgroundThis was the first microbicide trial conducted in Africa to evaluate an antiretroviral-containingvaginal ring as HIV prevention technology for women.ObjectivesThe assessed and compared safety, acceptability adherence product use ofa 4-weekly administered vaginal containing antiretroviral microbicide, dapivirine,with a matching placebo among women from four countries sub-Saharan Africa.Methods280 Healthy, sexually active, HIV-negative women, aged 18 40 years were enrolled with140...
Objective: Ovarian cancer has the highest mortality among gynecological cancers.High-grade serous carcinoma (HGSC) is most common histotype of ovarian regardlessof ethnicity, whereas clear cell (CCC) more in East Asians than Caucasians.The elucidation predominant signaling pathways these cancers first step towardsunderstanding their molecular mechanisms and developing clinical management. Methods:RNA sequencing was performed for 27 specimens from Japanese women. Principalcomponent analysis...