ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign, Synthesis, and Antiviral Activity of Certain 2,5,6-Trihalo-1-(.beta.-D-ribofuranosyl)benzimidazolesLeroy B. Townsend, Rodrigo V. Devivar, Steven R. Turk, M. Reza Nassiri, John C. DrachCite this: J. Med. Chem. 1995, 38, 20, 4098–4105Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September...

The combined cytotoxicity of zidovudine and ganciclovir in three cell lines human origin was examined. data were generated by a new rapid proliferation assay more sensitive plating efficiency assay. A three-dimensional analytical approach used to evaluate the drug-drug interactions, results compared with those obtained two conventional methods analysis. Synergistic observed all examined both assays. Moreover, this synergistic statistically significant at physiologically relevant...

Stable crystalline phosphorus ylides were obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylates presence of strong NH-acids, such as benzotriazole, 5-methylbenzotriazole, 5-chlorobenzotriazole, pyrrole, 2-acetylpyrrole, pyrrole-2-carboxaldehyde, 4-nitro-acetanilide, 4-methoxyacetanilide, 4-bromoacetanilide, 4-methylacetanilide, 2-methyl-acetanilide, 2,6-dimethylacetanilide. These stable exist a solution mixture two...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, cytotoxicity, and antiviral activity of some acyclic analogs the pyrrolo[2,3-d]pyrimidine nucleoside antibiotics tubercidin, toyocamycin, sangivamycinPranab K. Gupta, Sylvia Daunert, M. Reza Nassiri, Linda L. Wotring, John C. Drach, Leroy B. TownsendCite this: J. Med. Chem. 1989, 32, 2, 402–408Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February...

The sodium salts of 4-chloro- and several 4-chloro-5-substituted-7H-pyrrolo[2,3-d]pyrimidines were treated with [1,3-bis(benzyloxy)-2-propoxy]methyl chloride (6) to provide the corresponding 4-chloro-5-substituted-7-[[1,3-bis(benzyloxy)-2-propoxy]methyl]pyrrolo [2,3-d]pyrimidines (7-11). Debenzylation boron trichloride at -78 degrees C furnished 4-chloro-5-substituted-7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3- d]pyrimidines (12.16). Subsequent amination 12-16 yielded...

In this work, a new series of 1,2-diphenyl-3aH-spiro[benzo[d]pyrrolo[2,1-b]thaizol-3,5ʹ-pyrimidine (4) or 3,2ʹ-indendion (6) derivatives were efficiently designed and prepared using novel easy route in excellent yields by multicomponent-reactions between benzothiazoles, 2-chloro-2-phenylacetophenone, 1,3-dicarbonyl compounds. These reactions carried out CH2Cl2 at ambient temperature under catalyst-free conditions for 3 h. The structure all the synthesized compounds established NMR, IR, EI-MS...

Stable crystalline phosphorus ylides were obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylates, presence of strong NH-acids, such as imidazole, 2-methylimidazole, 4-methylimidazole, 2-ethylimidazole, benzimidazole, 5,6-dimethylbezimidazole. These stable exist solution a mixture two geometrical isomers result restricted rotation around carbon–carbon partial double bond resulting conjugation ylide moiety with adjacent...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin sangivamycinPranab K. Gupta, M. Reza Nassiri, Lisa A. Coleman, Linda L. Wotring, John C. Drach, Leroy B. TownsendCite this: J. Med. Chem. 1989, 32, 7, 1420–1425Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July...

In this study, arylglyoxals, acetylacetone, and 2,6-dimethyl phenol or 2,6-di-tert-butyl are combined to efficiently synthesize a series of 1-(4-(3,5-dialkylphenyl)-2-methyl-5-phenylfuran-3-yl) ethan-1-one derivatives in excellent yields. These reactions were carried out acetone at reflux under catalyst-free conditions the presence triethylamine as base for 3 h. NMR, FT-IR, EI-MS, elemental studies used characterize products' structural characteristics. The present study has also several...

Stable crystalline phosphorus ylides were obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylates, presence of strong NH-acids, such as pyrazole, indazole 5-nitro Indazole. These stable exist solution a mixture two geometrical isomers result restricted rotation around carbon–carbon partial double bond resulting conjugation ylide moiety with adjacent carbonyl group.

Abstract Stable crystalline phosphorus ylides were obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylates, presence of NH‐acid, such as 3,6‐dibromocarbazole. These stable exist solution a mixture two geometrical isomers result restricted rotation around carbon–carbon partial double bond, resulting conjugation ylide moiety with adjacent carbonyl group. To determine kinetic parameters reactions, they monitored by UV...

Stable crystalline phosphorus ylides containing chlorine and sulfur were obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine dialkyl acetylene-dicarboxylates presence of 6-chloro-2-benzoxazolethiol 2-chloro-phenothiazine. These stable exist solution as a mixture two geometrical isomers. This is caused by conjugation ylide moiety with adjacent carbonyl group, which results restricted rotation around respective carbon-carbon bond.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Antiproliferative Antiviral Activity of 2'-Deoxy-2'-fluoroarabinofuranosyl Analogs the Nucleoside Antibiotics Toyocamycin SangivamycinSteven H. Krawczyk, M. Reza Nassiri, Louis S. Kucera, Earl R. Kern, Roger G. Ptak, Linda L. Wotring, John C. Drach, Leory B. TownsendCite this: J. Med. Chem. 1995, 38, 20, 4106–4114Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antiviral activity of certain 4- 4,5-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidinesJeffrey S. Pudlo, Naveen K. Saxena, M. Reza Nassiri, Steven R. Turk, John C. Drach, Leroy B. TownsendCite this: J. Med. Chem. 1988, 31, 11, 2086–2092Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November...

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

Stable crystalline phosphorus ylides were obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylates presence of strong SH-acids, such as 2-mercapto-1-methylimidazole 2-thiazoline-2-thiol. These stable exist solution a mixture two geometrical isomers result restricted rotation around carbon–carbon partial double bond resulting conjugation ylide moiety with adjacent carbonyl group.

The reaction between dialkyl acetylenedicarboxylates and N-H acids such as pyrazole indazole in the presence of triphenylphosphite at room temperature led to stable phosphonate ester derivatives 4a-f.The configuration compounds 4a-f (2S * ,3R ) was determined on basis coupling constants predicted from Karplus equation.

Stable crystalline phosphorus ylides were obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylates presence of strong NH acids, such as indole 2-methyl indole, 3-methyl 5-boromo indole. These stable exist a solution mixture two geometrical isomers result restricted rotation around carbon–carbon partial double bond resulting conjugation ylide moiety with adjacent carbonyl group.