A5089413758- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Molecular Biology Techniques and Applications
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Chemokine receptors and signaling
- vaccines and immunoinformatics approaches
- Intramuscular injections and effects
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- Economic and Financial Impacts of Cancer
- Cell Image Analysis Techniques
- Extracellular vesicles in disease
- Antimicrobial Peptides and Activities
National Cancer Institute
2014-2025
Laboratory of Molecular Genetics
2025
Vilnius Gediminas Technical University
2021-2024
National Cancer Institute
2024
Vilnius University
2005-2014
Lithuanian Ornithological Society
1997
Superparamagnetic iron oxide nanoparticles (SPIONs) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, both toxicity biological activity of SPIONs should be evaluated in detail. The aim this study was to synthesize superparamagnetic cobalt ferrite (Co-SPIONs), investigate their uptake, effects on stem-like properties human pancreatic cell line MiaPaCa2 ovarian A2780.Co-SPIONs were produced by Massart's co-precipitation method. cells treated with Co-SPIONs...
This study aimed to evaluate the diagnostic potential of soluble Programmed Death Ligand 1 (sPD-L1) and (sPD-1) molecules in plasma, along with urinary mRNA biomarkers—Prostate-Specific Membrane Antigen (PSMA), Prostate Cancer 3 (PCA3), androgen receptor (AR) genes—for identifying clinically significant prostate cancer (PCa), defined as pathological stage 3. In a cohort 68 PCa patients, sPD-L1 sPD-1 levels were quantified using ELISA, while transcripts measured by RT-qPCR. Results highlight...
The tumor microenvironment plays a pivotal role in cancer progression and therapeutic resistance, with tumor-associated macrophages significantly influencing immune suppression growth. Colorectal cancers (CRC) classified as Consensus Molecular Subtype 4 (CMS4) triple-negative breast subsets are particularly characterized by mesenchymal phenotype, exclusion, extensive macrophage infiltration. This study aimed to investigate how targeting cell stemness specific inhibitors could modulate...
Chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy and unique long-term outcomes in treating relapsed/refractory hematological malignancies both pediatric adult patients. However, a subset of patients remains unresponsive, with disease progression continuing despite treatment. Moreover, CAR-T shown limited success solid tumors. Accumulating evidence on the role various lymphocyte subpopulations antitumor immunity suggests that cytokine-induced killer (CIKs)...
Colorectal cancer (CRC) is a heterogeneous disease characterized by diverse tumor microenvironment comprising immune and non-immune components. Acquired mutations phenotypic plasticity in the create diversity of cells whose interactions contribute to progression resistance anticancer therapy through various activated mechanisms. At molecular level, four subtypes colorectal (CMS1-4) have been validated, differing their aggressive characteristics infiltration. With rapid development oncology...
Background:Soluble PD-1 (sPD-1) and PD-L1 (sPD-L1) are emerging biomarkers in prostate cancer (PCa), yet their cellular origins interactions within the tumor microenvironment (TME), particularly with NK cells, immunosuppressive Tregs, MDSCs, remain poorly understood. This study also explores biomarker combinations for better clinically significant PCa stratification. Methods:A total of 88 patients (pT2 pT3) were enrolled. Plasma levels sPD-1 sPD-L1 measured using ELISA. A control group 41...
Different patterns of immune and stromal interactions within the tumor microenvironment significantly impact behavior response to treatment. Recent research has identified distinct subtypes—immune desert, excluded, inflamed—each associated with specific mechanisms that impede anti-tumor responses. In era precision medicine, accurately stratifying patients into these subtypes is essential for optimizing cancer management personalizing immunotherapy. The team at National Cancer Institute in...
Purpose The aim of this study was to assess the role sPD-L1 and sPD-1 as potential biomarkers in prostate cancer (PCa). association values these soluble proteins were correlated clinical data: stage disease, Gleason score, biochemical recurrence etc. For a comprehensive study, relationship between circulating immune cells further investigated. Methods A total 88 patients with pT2 pT3 PCa diagnosis 41 heathy men enrolled. Soluble levels measured plasma by ELISA method. Immunophenotyping...
Abstract Problem The current tumor immunology paradigm emphasizes the role of immune microenvironment and distinguishes several histologically transcriptionally different subtypes. However, experimental validation such classification is so far limited to selected cancer types. Here, we aimed explore existence inflamed, excluded, desert subtypes in ovarian cancer, as well investigate their association with disease outcome. Method study We used publicly available dataset from Cancer Genome...
Abstract Background Presently available flow cytometric methods of bromodeoxyuridine (BrdUrd) labelling do not provide information on the cell cycle time (T C ) and growth fraction (GF). In this paper, we describe a novel simple method to estimate T GF from analysis single tumour sample after BrdUrd labelling. Methods The proposed is based two assumptions: (1) number labelled cells traversing per unit constant (2) total throughout cycle, provided that produced division are excluded. numbers...
Problem Development of platinum resistance in ovarian cancer is mediated by both cells and tumor microenvironment. Activation epithelial‐mesenchymal transition program may lead to enrichment for resistant clones. These processes can be affected tumor‐associated macrophages, a highly plastic population that participate progression response treatment shaping the We aimed study how influences crosstalk between macrophages cells. Method Using cisplatin‐sensitive cell line A2780, we developed...
Multiple studies demonstrate significantly better therapeutics outcomes in smokers as compared with never when single-agent immunotherapy is applied. Non-smoker patients usually need a combination of chemoimmunotherapy to achieve comparable or slightly therapeutic results. This effect thought be due tobacco product-induced upregulation PD-L1/PD-1 expression and tumor mutational burden score. Genomic transformation, however, cannot entirely explain the PD-L1/PL-1 cells following short-term...