A5022338378- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Animal Behavior and Reproduction
- Urinary and Genital Oncology Studies
- Invertebrate Immune Response Mechanisms
- Cancer Genomics and Diagnostics
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- AI in cancer detection
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Natural Products and Biological Research
- Insect behavior and control techniques
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Botanical Research and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Amyotrophic Lateral Sclerosis Research
University of California, Los Angeles
2014-2022
Genentech
2014-2015
Howard Hughes Medical Institute
2010-2011
Stanford University
2010
The Drosophila olfactory system exhibits very precise and stereotyped wiring that is specified predominantly by genetic programming. Dendrites of projection neurons (PNs) pattern the developing antennal lobe before receptor neuron axon arrival, indicating an intrinsic mechanism for PN dendrites. These decisions are likely determined through a transcriptional program.We find loss Brahma associated protein 55 kD (Bap55) results in highly specific mistargeting phenotype. In Bap55 mutants, PNs...
Compared to the mechanisms of axon guidance, relatively little is known about transcriptional control dendrite guidance. The <i>Drosophila</i> olfactory system with its stereotyped organization provides an excellent model study wiring specificity. Each projection neuron (PN) targets dendrites a specific glomerulus in antennal lobe and stereotypically higher brain centers. Using forward genetic screen, we identified mutation <i>Rpd3</i> that disrupts PN targeting encodes class I histone...
The human brain comprises more than 100 billion neurons, each of which has an elaborate shape and a complex pattern connections. To untangle this complexity, it is often useful to visualize one neuron at time. Mosaic analysis with double markers (MADM) genetic method for labeling manipulating individual neurons. This was developed in mice allows simultaneous gene knockout clones somatic cells or isolated single vivo. In MADM, achieved by using site-specific recombinases induce the...
The formation of a functional organ such as the eye requires specification correct cell types and their terminal differentiation into cells with appropriate morphologies functions. Here, we show that zinc-finger transcription factor Blimp-1 acts in secondary tertiary pigment Drosophila retina to promote bi-convex corneal lens normal refractive power, cone enable complete extension photoreceptor rhabdomeres. expression depends on hormone ecdysone, loss ecdysone signaling causes similar...
The Drosophila melanogaster eye disc is a powerful system that can be used to study many different biological processes. It contains approximately 800 separate units, termed ommatidia1. Each ommatidium eight neuronal photoreceptors develop from undifferentiated cells following the passage of morphogenetic furrow in third larval instar2. Following sequential differentiation photoreceptors, non-neuronal develop, including cone and pigment cells, along with mechanosensory bristle cells3. Final...
<h3>Background</h3> Tertiary Lymphoid Structures (TLS) are aggregates of immune cells that form at sites chronic inflammation. Presence tumor-associated TLS has recently been shown to associate with checkpoint inhibitor response independent known biomarkers. This makes induction a promising mechanism for novel immunotherapy target discovery. However, the gold standard detection method by pathologists is both time and labor intensive, limiting biology research scale. Recent advances in AI...
<h3>Background</h3> While the field has made significant advances in understanding cancer-immunity cycle and defining patient 'immunotypes', predicting clinical success for a therapeutic given population remains an unsolved problem. Meanwhile, of artificial intelligence (AI) have aided design molecules to drug known targets, but not helped identify novel targets their appropriate populations. Furthermore, recent technological enabled high-resolution, multiplexed spatial profiling cells,...
541 Background: Biomarker analysis predicting outcome with neoadjuvant atezolizumab in muscle invasive bladder cancer (MIBC) was performed. This includes previously unreported findings FOXP3 and MHC1. Methods: Sequential tissue obtained from 95 patients the ABACUSstudy (NCT02662309) which investigated two cycles of prior to cystectomy MIBC patients. Multiplex immunohistochemistry staining, Foundation One RNA sequencing performed on paired pre- post- treatment samples. CD8+ T cells,...
2519 Background: Resistance to immune checkpoint blockade (ICB) can manifest as disease progression either at the initiation of treatment (primary resistance) or after some initial response (acquired resistance). To better understand mechanisms underlying acquired resistance, imCORE Network is conducting a study (NCT03333655) examine changes in tumor biology from pre-treatment across cancer types. Methods: Eligible patients included those experiencing clinical benefit on ICB (defined...