A5010308319- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Metal Alloys Wear and Properties
- Chemical synthesis and alkaloids
- Powder Metallurgy Techniques and Materials
- CAR-T cell therapy research
- Metallurgy and Material Forming
- Inflammatory mediators and NSAID effects
- Analog and Mixed-Signal Circuit Design
- Advancements in Semiconductor Devices and Circuit Design
- Ovarian cancer diagnosis and treatment
- Hydrocarbon exploration and reservoir analysis
- Cancer-related molecular mechanisms research
- Plant and Fungal Species Descriptions
- Pesticide and Herbicide Environmental Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Botanical Research and Chemistry
- Recycling and utilization of industrial and municipal waste in materials production
- Chemical Reactions and Mechanisms
- Scientific Research and Discoveries
- Optical Imaging and Spectroscopy Techniques
- Plant Toxicity and Pharmacological Properties
- NF-κB Signaling Pathways
- Historical and Architectural Studies
University of Minnesota
2013-2024
Carnegie Mellon University
2022
Mayo Clinic
2013
San Diego State University
1994-2000
Duke University
1990-1992
Memorial University of Newfoundland
1988
Centre National de la Recherche Scientifique
1988
Arkansas Agricultural Experiment Station
1937
Abstract Ovarian cancer is a clinically and molecularly heterogeneous disease. The driving forces behind this variability are unknown. Here, we report wide variation in the expression of DNA cytosine deaminase APOBEC3B, with elevated majority ovarian cell lines (three SDs above mean normal surface epithelial cells) high-grade primary cancers. APOBEC3B active nucleus several elicits biochemical preference for deamination cytosines 5′-TC dinucleotides. Importantly, examination whole-genome...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+)-griseofulvinMichael C. Pirrung, William L. Brown, Sushil Rege, and Pierre LaughtonCite this: J. Am. Chem. Soc. 1991, 113, 22, 8561–8562Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://doi.org/10.1021/ja00022a075Request reuse permissionsArticle Views1510Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text...
Abstract SARS-CoV-2 nucleocapsid (N) protein is a structural component of the virus with essential roles in replication and packaging viral RNA genome. The N also an important target COVID-19 antigen tests promising vaccine candidate along spike protein. Here, we report compact stem-loop DNA aptamer that binds tightly to N-terminal RNA-binding domain Crystallographic analysis shows hexanucleotide motif (5′-TCGGAT-3′) fits into positively charged concave surface N-NTD engages residues...
Iron alum, used as a pie-mordant, makes possible the use of smears on materials that do not smear satisfactorily otherwise.Chromosomes which stain well after storage when usual methods are employed give satisfactory results with modified method.
Diffuse correlation spectroscopy (DCS) has been widely explored for its ability to measure cerebral blood flow (CBF), however, mostly under the assumption that human head is homogenous. In addition CBF, knowledge of extracerebral layers, such as skull thickness, can be informative and crucial patient with brain complications traumatic injuries. To bridge gap, this study feasibility simultaneously extracting thickness in cortex layer using DCS. We validated a two-layer analytical model...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiazotization of 1-aminocyclopropanecarboxylic acid. Solution chemistry oxaspiropentanoneMichael C. Pirrung and William L. BrownCite this: J. Am. Chem. Soc. 1990, 112, 17, 6388–6389Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://doi.org/10.1021/ja00173a032RIGHTS & PERMISSIONSArticle Views1005Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the...
Abstract A short‐contact‐time catalytic combustor described here is capable of incinerating air streams with low concentrations volatile organic compounds (VOCs) at conversions exceeding 99.5% for contact times on the order 5 ms. This accomplished by adding methane to VOC‐containing stream increase fuel value and then passing mixture over a platinum‐coated foam ceramic monolith 900 – 1,400°C. The incineration containing toluene, chlorobenzene, acetonitrile, thiophene was examined ranging...
In an earlier paper, the authors analyzed and offered solutions to several discrepancies that often arise when electronic engineering students seek understand reconcile their hand calculations with Spice simulation results. This paper presents additional commonly encountered, but quite unexpected, problems frustrate confuse students. particular, discuss difficulties from use of Miller compensation in middle gain stage a typical bipolar op amp, occur transistor is operating "high level...
Students enrolled in a capstone design course on analog integrated circuits often encounter calculational difficulties when they attempt to verify key circuit parameters predicted by computer simulations using SPICE. Discrepancies between their hand calculations and SPICE values sometimes exceed 200%. This paper reviews some commonly encountered discrepancies, describes major causes of significant errors, offers solutions that have been found be effective. In particular, this discusses the...
This paper promotes the use of some little-used but most valuable theorems that are available to students in introductory network analysis: voltage and current shifting theorems; source reduction theorem; substitution theorem. Examples illustrate how these can be used solve for one or more variables many networks contain dependent as well independent sources. Network simplification techniques maximized equations is minimized. A extensive duality concept also recommended.
<p>Table S1 has RTqPCR primers and probe information. Table S2 clinical information for the Dutch cohort. S3 a summary of TCGA samples used in our analyses. Figure assay validation data. shows correlations APOBEC3G expression independent cohorts.</p>
<p>PDF file - 481K, Table S1: Cell line information S2: Quantitative PCR primer and probe sequences. S3: Non-malignant tissues tested S4: Early stage serous ovarian tumors used in sequence analyses S5: Additional tumor specimens analyzed S6: Microarray analysis of APOBEC3 select control gene sets TCGA data Figure Polynucleotide cytosine deaminase expression cell lines. Endogenous DNA activity APOBEC3B high low on alternate dinucleotide substrates. primary samples. samples by RNAseq.</p>
<div>Abstract<p><b>Purpose:</b> APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated activity causes mutations in cancer. Because of broad expression profiles varying mixtures normal cancer cells tumors, including immune cell infiltration, it is difficult to determine where different APOBEC3s are expressed. Here, we ask whether correlations exist between <i>APOBEC3</i> T-cell infiltration...
<div>Abstract<p><b>Purpose:</b> APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated activity causes mutations in cancer. Because of broad expression profiles varying mixtures normal cancer cells tumors, including immune cell infiltration, it is difficult to determine where different APOBEC3s are expressed. Here, we ask whether correlations exist between <i>APOBEC3</i> T-cell infiltration...
<div>Abstract<p>Overexpression of the antiviral DNA cytosine deaminase APOBEC3B has been linked to somatic mutagenesis in many cancers. Human papillomavirus infection accounts for upregulation cervical and head/neck cancers, but mechanisms underlying nonviral malignancies are unclear. In this study, we investigated signal transduction pathways responsible upregulation. Activation protein kinase C (PKC) by diacylglycerol mimic phorbol-myristic acid resulted specific...