A5062947061- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Inorganic and Organometallic Chemistry
- Biochemical and Molecular Research
- Synthesis and Biological Evaluation
- Morinda citrifolia extract uses
- Advancements in Battery Materials
- Synthesis of Organic Compounds
- Metal complexes synthesis and properties
- Free Radicals and Antioxidants
- Supercapacitor Materials and Fabrication
- Electrocatalysts for Energy Conversion
- Synthesis and Characterization of Heterocyclic Compounds
- Alkaline Phosphatase Research Studies
- Organic and Inorganic Chemical Reactions
Savitribai Phule Pune University
2013
Four 2,6-di-tert-butyl-1,4-benzoquinone hydrazones have been synthesized viz.A1, A2, A3 and A4.The purity was checked using HPLC.These compounds were characterized by FTIR H 1 -NMR they shows a prominent absorption of -(C=N-) in FTIR.It also common peak oleifinic proton at 6.50 Hz.These tested for their antimicrobial activity against Gram +ve -ve bacteria.A3 found to be active minimum concentration 50 μg•mL -1 where as A2 inactive.
A new series of Schiff's bases, SB1, SB2 and SB3 were synthesized from 3-acetylcoumarin different acid hydrazides.The 3-acetyl coumarin was starting salicylaldehyde ethylacetoacetate.The structures the compounds have been established on basis physical spectral data.They shows a prominent absorption -(C=N-) in FTIR.A survey existing literature revealed that there are no reports describing synthesis such hydrazones.
In this work, the multifunctional potential of four 3-acetylcoumarin derivatives was studied. The were significantly active against bacteria Staphylococcus aureus, Pseudomonas aeoginosa and fungal strain Candida albicans. results antioxidant activity assays promising when compared to ascorbic acid. in vitro anticancer carried out using MTT assay on human cancer cell line COLO-205 3ACDT showed commendable antiproliferative along with appreciable tumor selectivity distinct index. Moreover,...
To develop new alkaline phosphatase inhibitors, a series of azo coumarin derivatives were designed by using computer aided drug designing and virtually assessed online platforms. At first, the compounds screened for ADMET, physicochemical properties, drug-likeness, toxicity studies target prediction pKCSM, SwissADME, SwissTargetPrediction ProTox-II tools. The predictions supported in silico molecular docking with enzyme CB-Dock2 tool. possessed good ADMET drug-likeness devoid any...
Under solvent free conditions and in presence of a base 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives were synthesized by grinding technique. Structural investigations carried out with IR studies, HRMS, 1HNMR 13CNMR. The compounds checked for their vitro anticancer activities against three different human cancer cell lines viz breast line (MCF-7), cervical (HeLa) oral squamous carcinoma (SCC-40) using SRB method. All the title showed low toxicity towards...
We report the synthesis, structural characterization and pharmaceutical activity of four coumarin-quinone hybrids. The compounds were significantly active against Staphylococcus aureus, Pseudomonas aeoginosa Candida albicans. Promising antioxidant was observed when compared to ascorbic acid. Two compounds, DTBSB DTBSN, also showed commendable in vitro antiproliferative activities cells human cancer cell lines MCF-7, MDA-MB-231, COLO-205, HT-29 A549 along with appreciable tumor selectivity...
3-acetylcoumarin hydrazone scaffolds, synthesized from and substituted benzoic acid hydrazides are reported with structural characterization using IR, HRMS, 1H 13C-NMR. The In vitro anticancer activities against three human cancer cell lines viz. MCF-7 (human breast line), HeLa cervical line) SCC-40 oral squamous carcinoma) carried out while the tumour selectivity of compounds tested on normal peripheral blood mononuclear cells (PBMCs). 3ACOH, 3ACDH 3ACMH exhibited higher sensitivity towards...