A5065530337- Alzheimer's disease research and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Medicinal Plants and Neuroprotection
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Attachment and Relationship Dynamics
- Anesthesia and Neurotoxicity Research
- Migration, Health and Trauma
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health Treatment and Access
- Immunotoxicology and immune responses
- Maternal Mental Health During Pregnancy and Postpartum
- Intensive Care Unit Cognitive Disorders
Feinstein Institute for Medical Research
2018-2025
Northwell Health
2021-2025
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2018-2022
National Institutes of Health
2018
Johns Hopkins University
2018
Office of Extramural Research
2018
Uniformed Services University of the Health Sciences
2018
National Institute of Mental Health
2017
Targeting tau protein is a strategy for the development of disease-modifying therapeutics Alzheimer's disease (AD) and numerous rare tauopathies. A small molecule approach targeting aggregation was used to select optimize compounds inhibiting self-association in vitro that have translated vivo preventive studies htau P301L JNPL3 mouse models tauopathy. In this therapeutic treatment study, aged mice with pre-existing aggregates were evaluate effect OLX-07010. The study had Baseline group 7...
Psychosis that occurs over the course of Alzheimer’s disease (AD) is associated with increased caregiver burden and a more rapid cognitive functional decline. To find new treatment targets, studies modeling psychotic conditions traditionally employ agents known to induce psychosis, utilizing outcomes cross-species relevance, such as locomotive activity sensorimotor gating, in rodents. In AD, burdens tau pathology (a diagnostic hallmark disease) anticholinergic medications have, separately,...
Exposure to anesthesia in the elderly might increase risk of dementia. Although mechanism underlying association is uncertain, has been shown induce acute tau hyperphosphorylation preclinical models. We sought investigate impact on gene expression and long-term changes biochemistry transgenic models tauopathy order better understand how influences pathophysiology dementia.We exposed mice with over-expressed human mutant (P301L hyperdopaminergic COMTKO/P301L) two hours isoflurane compared...
Abstract Background Small molecules were screened and optimized for inhibiting tau self‐association, the initial step in formation of soluble toxic oligomers larger insoluble aggregates. This approach is differentiated from other aggregation inhibitor programs that have largely focused on and/or dissociating large relatively inert fibrils which could generate oligomer seeds. inhibitors are agnostic to specific post‐translational modifications, conformational changes or strains aggregates,...