Cortisol has been implicated as a pathophysiological mediator in idiopathic obesity, but circulating cortisol concentrations are not consistently elevated. The tissue-specific responses to may be influenced much by local prereceptor metabolism concentrations. For example, liver and adipose tissue is regenerated from inactive cortisone 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). In obese Zucker rats 11β-HSD1 activity reduced enhanced tissue. This study addressed whether the same...

Cushing's syndrome and the metabolic share clinical similarities. Reports of alterations in hypothalamic-pituitary-adrenal (HPA) axis are inconsistent, however, syndrome. Recent data highlight importance adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which regenerates cortisol from cortisone and, when overexpressed fat, produces central obesity glucose intolerance. Here we assessed HPA 11β-HSD1 activity women with moderate insulin resistance. Forty were divided into tertiles...

In idiopathic obesity circulating cortisol levels are not elevated, but high intraadipose concentrations have been implicated. 11β-Hydroxysteroid dehydrogenase type 1 (11HSD1) catalyzes the conversion of inactive cortisone to active cortisol, thus amplifying glucocorticoid receptor (GR) activation. cohorts men and women, we shown increased ex vivo 11HSD1 activity in sc adipose tissue associated with insulin resistance. Using these biopsies, now validated this observation by measuring GR mRNA...

OBJECTIVE—To investigate whether features of the insulin resistance syndrome are associated with altered incretin responses to food intake. RESEARCH DESIGN AND METHODS—From a population-based study, 35 men were recruited, representing wide spectrum sensitivity and body weight. Each subject underwent hyperinsulinemic-euglycemic clamp determine sensitivity. A mixed meal was given, plasma levels gastric inhibitory polypeptide (GIP) glucagon-like peptide 1 (GLP-1), as well insulin, glucagon,...

Summary Objective Causes of visceral fat accumulation include glucocorticoid excess or decreased oestrogen/androgen ratio either in plasma within adipose tissue. In obese subjects, the intra‐adipose cortisol‐generating enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) is increased, but information on sex steroid signalling sparse. We aimed to test associations between body distribution and mRNA transcript levels for androgen oestrogen receptors enzymes metabolizing steroids Design A...

Cortisol has been implicated as a pathophysiological mediator in idiopathic obesity, but circulating cortisol concentrations are not consistently elevated. The tissue-specific responses to may be influenced much by local prereceptor metabolism concentrations. For example, liver and adipose tissue is regenerated from inactive cortisone 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). In obese Zucker rats 11β-HSD1 activity reduced enhanced tissue. This study addressed whether the same...

Abstract Objectives Kisspeptin plays a major role in the onset of puberty by stimulating gonadotropin-releasing hormone (GnRH) neurons. The aim this study was to investigate whether GnRH inhibits kisspeptin secretion via negative feedback mechanism and potential associations between levels other hormones importance for pubertal onset. Methods Thirteen girls with suspected central precocious underwent stimulation test twice randomized, placebo-controlled manner. Blood sampled up 150 min after...

Increased glucocorticoid metabolite excretion and enhanced expression activity of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue are closely correlated with obesity its detrimental consequences. Weight loss ameliorates the latter. The aim this study was to explore whether increased exposure is improved substantial weight thus a consequence rather than cause obesity.A prospective cohort 31 women.11β-HSD activity, urinary excretion, body composition including regional depots insulin...

Several observational studies have shown an association between vitamin D deficiency and non-skeletal major health issues including impaired cardiorespiratory fitness adiposity. Only a few examined the impact of supplementation on these conditions results are ambiguous. The aim this study was to examine effect body composition in overweight/obese men with deficiency. This prospective, placebo controlled, double blinded, randomized trial period 6 months. Forty (BMI > 25 kg/m2) (25(OH)D ≤ 55...

The glucocorticoid activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) is of major interest in obesity-related morbidity. Alterations tissue-specific cortisol levels may influence lipogenetic and gluco/glyceroneogenetic pathways fat liver. We analyzed the expression activity 11betaHSD1 as well phosphoenolpyruvate carboxykinase (PEPCK), sterol regulatory element binding protein (SREBP), fatty acid synthase (FAS) adipose liver investigated putative associations between...

Background and Aims: The role of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in the pathogenesis obesity has been elucidated humans various rodent models. Obesity is accompanied by disturbances glucocorticoid metabolism, circulating adipokine levels, fatty acid (FA) reesterification. This study was undertaken to evaluate metabolism sc fat before after weight loss explore putative associations between 11β-HSD1 leptin, adiponectin, FA recycling. Subjects Methods: Twenty-seven obese (mean...

Summary Objective The menopausal transition is characterized by increased body fat accumulation, including redistribution from peripheral to central depots. This distribution associated with an risk of type 2 diabetes and cardiovascular disease that are linked low‐grade inflammation. We determined whether postmenopausal women have higher levels inflammatory markers, compared premenopausal women. also wanted determine these markers reduced stable weight loss in obese Design methods...

Objective—Obstructive sleep apnea has been reported to occur in 20–50% of children with Down's syndrome case series patients referred for evaluation suspected apnea. In this population-based controlled study, we aimed investigate whether is related syndrome.Material and Methods—Every child aged 2–10 years residing the Umeå healthcare district (n = 28) was invited participate their siblings acting as controls. Successful overnight recordings echocardiography were performed 17/21 21...

Summary Dumping and post‐bariatric hypoglycaemia (PBH) are side effects that occur after bariatric surgery. The aim of this study was to estimate the prevalence dumping PBH symptoms before Roux‐en‐Y gastric bypass (RYGB) sleeve gastrectomy (SG) at 6 months, 1 year, 2 years 5 surgery in a Swedish population. A cross‐sectional single‐centre performed Lindesberg Hospital, Region Örebro County, Sweden, between 2020 2023. version Severity Scale (DSS‐Swe) questionnaire, which includes eight items...

Abstract Background The aim of the present study was to longitudinal changes in bone mineral density (BMD), vitamin D, and parathyroid hormone (PTH) levels females over a 10-year period after laparoscopic Roux-en-Y gastric bypass (LRYGB). Methods Twenty-three women, mean age 43.4 ± 8.7 years body mass index (BMI) 44.6 5.17 kg/m 2 at baseline, were included. BMD, BMI, S-calcium, S-25(OH)-vitamin fP-PTH measured preoperatively 2, 5, 10 postoperatively. Results Ten surgery, BMD spine femoral...

Abstract Background Bariatric surgery improves insulin sensitivity and secretion in patients with type 2 diabetes, but the effect on prediabetes or even normal glucose tolerance deserves further consideration. Methods Cohort study including operated laparoscopic Roux-en-Y gastric bypass (LRYGB) between November 2012 June 2017 at Örebro University Hospital ( n = 813) follow-up of 742 years after surgery. Fasting insulin, glucose, glycosylated hemoglobin (HbA1c), homeostatic model assessment...