A5089607972- Selenium in Biological Systems
- Trace Elements in Health
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Heavy Metal Exposure and Toxicity
- Chronic Lymphocytic Leukemia Research
- Cancer Treatment and Pharmacology
- Neuropeptides and Animal Physiology
- Acute Lymphoblastic Leukemia research
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced organ toxicity mitigation
- Adipokines, Inflammation, and Metabolic Diseases
- Monoclonal and Polyclonal Antibodies Research
- Plant Virus Research Studies
- Colorectal Cancer Treatments and Studies
- Blood disorders and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- Biomedical Research and Pathophysiology
- Hormonal and reproductive studies
- Lipid metabolism and disorders
University of Waikato
2016-2024
University of Auckland
2019
AstraZeneca (United Kingdom)
1994-2018
Waikato Hospital
2014
Royal Marsden NHS Foundation Trust
2009-2012
Royal Marsden Hospital
2007-2011
Children's Hospital at Westmead
1999
Georgetown University Medical Center
1994
Cancer Research Center
1994
Georgetown University
1994
This work presents the first systematic comparison of selenium (Se) speciation in plasma from cancer patients treated orally with three Se compounds (sodium selenite, SS; L-selenomethionine, SeMet; or Se-methylselenocysteine, MSC) at 400 µg/day for 28 days. The primary goal was to investigate how these chemical forms affect distribution, aiming identify most effective compound optimal selenoprotein expression. achieved using methodology based on HPLC-ICP-MS after sample...
Summary Targeted gene regulation via designed transcription factors has great potential for precise phenotypic modification and acceleration of novel crop trait development. To this end, transcriptional activators have been constructed by fusing activation domains to DNA ‐binding proteins. In study, a activator from the herpes simplex virus, VP 16 , was used identify plant regulatory Transcriptional were identified each protein fused with zinc finger proteins ( ZFP s) generate activators....
Abstract Graft‐versus‐host disease (Gv HD ) is a common complication following haematopoietic stem cell transplant but little published about the impact of this condition on hospital readmission rates. We report retrospective analysis rates and associated costs in 187 consecutive allogeneic patients to assess G v . The overall rate was higher with (86% (101/118) vs. 59% (41/69), p < 0.001). both first 100 d from (p = 0.02) year 151/455 (33%) all episodes occurred within transplant. mean...
AZD5363 is a potent pan-AKT inhibitor originally formulated as capsule; tablet was developed for patient convenience and manufacturing ease. This study assessed the PK comparability of both formulations (Part A) effect food B) on PK/safety tablet. Adults with advanced solid tumours received 480 mg bid in partially fasted state by (Week 1) capsule 2) '4-days-on/3-days-off' schedule A). parameters were evaluated using pre-defined 90% CIs AUCτ Cmax ratios 0.75–1.33 to assess comparability. In...
Mycophenolate mofetil (MMF) is used to treat acute and chronic graft versus host disease (GvHD). There scant evidence in the literature about mycophenolic acid (MPA) trough level monitoring GvHD. We therefore reviewed 32 patients treated with MMF for (n = 19) or GvHD 13). Twelve (63%) of 19 nine (69%) 13 showed a good response. In all 21 who responded MMF, their mean total MPA levels were therapeutic (1-3.5 mg/L), whereas five 11 did not respond had sub-therapeutic (p 0.002). Sixteen (66%)...
DNA damage quantitation assays such as the comet assay have focused on measurement of total nuclear per cell. The adoption PCR-based techniques to quantify has enabled sequence- and organelle-specific assessment lesions. Here we report an adaptation a qPCR technique assess in mitochondrial targets relative control. Novel aspects this include application Rotor-Gene platform with optimized polymerase/fluorophore/primer set combination touchdown PCR protocol. Assay validation was performed...
The human breast carcinoma cell line T47D is known to express high-affinity calcitonin receptors (CTRs). PCR amplification of the CTR cDNA from mRNA resulted in identification two different cDNAs that encode distinct receptor isoforms, h alpha and beta CTR. are identical except contains a 48 bp insert sequence encodes 16 amino acid domain first cytosolic loop receptor. Stable transfection each into murine erythroleukaemia (MEL) cells expression with high affinity for radiolabelled salmon (h...
2577 Background: AZD5363 is a potent pan-Akt inhibitor and acts on cancers by blocking cell survival pathway. AZD5363, administered to patients in the fasted state, was originally formulated as capsule (C). For patient convenience ease of manufacture tablet (T) formulation has been developed. In vitro work indicated that T C perform similarly; PK comparability needed be verified introduce clinical programme. The effect food PK, safety tolerability unknown. Methods: Part A assessed whether...