A5061763493- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- HER2/EGFR in Cancer Research
- Gastroesophageal reflux and treatments
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Kruppel-like factors research
- RNA Interference and Gene Delivery
- Endometriosis Research and Treatment
- Gastrointestinal Tumor Research and Treatment
The University of Texas MD Anderson Cancer Center
2025
Mayo Clinic in Arizona
2020
University of Minnesota
2019-2020
University of Rochester Medical Center
2012-2015
University of Rochester
2011-2013
Recent studies emphasize the role of microbial metabolites in regulating gastrointestinal (GI) physiology through activation host receptors, highlighting potential for inter-kingdom signaling treating GI disorders. In this study, we show that tryptamine, a tryptophan-derived bacterial metabolite, stimulates mucus release from goblet cells via G-protein-coupled receptor (GPCR) 5-HT4R. Germ-free mice colonized with engineered Bacteroides thetaiotaomicron optimized to produce tryptamine (Trp...
Abstract Background Classification and risk stratification of pancreatic cysts are challenging because limited radiographic cytomorphologic features. Although molecular profiling has emerged as an ancillary test for cyst fluid (PCF), additional high‐sensitivity ‐specificity biomarkers still needed improved classification. Methods In this study, PCF from 93 patients, including intraductal papillary mucinous neoplasms ( n = 65), cystic 9), serous cystadenomas not otherwise specified 8),...
This study aimed to identify pathways and cellular processes that are modulated by exposure of normal esophageal cells bile acid.Barrett's esophagus most likely develops as a response stem the abnormal reflux environment. Although insights into underlying molecular mechanisms slowly emerging, much metaplastic process remains unknown.We performed global analysis gene expression in squamous or acid exposure. Differentially expressed genes were classified major biological functions using...
The microcystic, elongated, and fragmented (MELF) pattern of myoinvasion in endometrial carcinoma (EC) is associated with an increased risk lymph node metastasis. Our aim to assess the role cytokeratin immunohistochemical (IHC) stains detecting sentinel nodal metastasis MELF tumors.We recovered 19 EC hysterectomies lymphadenectomy from our files. Negative nodes were subjected AE1/AE3 IHC. Ten additional cases (SLN) biopsies primarily assessed by IHC also analyzed.Of EC, 6 had positive based...
Abstract: Amplification of the ERBB2 or HER2/Neu in colorectal cancer leads to downstream activation PI3K-AKT-ERK mediated pro-proliferative signaling cascade. Targeting HER2 with a humanized monoclonal antibody, such as trastuzumab pertuzumab, initiates antibody-dependent cellular cytotoxicity, cell-cycle arrest and impaired DNA repair leading apoptosis. The HER2-del16 splice variant is tumor-specific event that removes extracellular juxtamembrane domain promotes resistance HER2-targeted...
Abstract: Amplification of the ERBB2 or HER2/Neu in colorectal cancer leads to downstream activation PI3K-AKT-ERK mediated pro-proliferative signaling cascade. Targeting HER2 with a humanized monoclonal antibody, such as trastuzumab pertuzumab, initiates antibody-dependent cellular cytotoxicity, cell-cycle arrest and impaired DNA repair leading apoptosis. The HER2-del16 splice variant is tumor-specific event that removes extracellular juxtamembrane domain promotes resistance HER2-targeted...
Abstract Background: The lumen of the normal esophagus is covered by a nonkeratinized, stratified squamous epithelium. However, in individuals with prolonged gastroesophageal reflux disease epithelium gradually replaced more acid-resistant metaplastic columnar known as Barrett's Esophagus (BE). BE strongest risk factor for development esophageal adenocarcinoma. Understanding molecular mechanisms underlying formation fundamental to new and effective prevention treatment strategies patients...