Hirsutellone F (7), a novel alkaloid dimer, was isolated together with known monomers, hirsutellones A (1), B (2), and C (3), from the seed fungus Trichoderma sp. BCC 7579. The structure of 7 elucidated by spectroscopic analysis. Studies on biomimetic chemistry, using dimer 7, suggested that compound 8 (17,1'-dehydrohirsutellone B) should be precursor for all hirsutellones.

The screening of exopolysaccharides (EPS) produced by 52 isolates endophytic and basidiomycete fungi was studied on two different media, PDB PYGM. There were five that could produce dried exopolysaccharide more than 4 g/L (S. commune LF01962, LF01001, LF01581, Pycnoporus sp. MMCR00271.1, Pestalotiopsis PP0005). molecular weights these exopolymers found to be in the range 2.5–500 kDa. These exopolysaccharides, fungal isolates, showed non-cytotoxic activity against NCTC clone 929 HDFn cell...

Two new pimarane-type diterpenes, eutypellones A (1) and B (2), were isolated from the endophytic fungus Eutypella sp. BCC 13199. Cytotoxic activities of pimaranes 1—5, this fungus, evaluated.

Abstract A mathematical model of the l ‐arabinose/ d ‐xylose catabolic pathway Aspergillus niger was constructed based on kinetic properties enzymes. For this purpose ‐arabinose reductase, ‐arabitol dehydrogenase and reductase were purified using dye‐affinity chromatography, their characterized. other enzymes data available from literature. The metabolic used to analyze flux metabolite concentration control pathway. demonstrated that does not reside at enzyme following intermediate with...

Biopolymers have various applications in medicine, food and petroleum industries. The ascomycetous fungus Ophiocordyceps dipterigena BCC 2073 produces an exobiopolymer, a (1→3)-β-D-glucan, low quantity under screening conditions. Optimization of O. exobiopolymer production using experimental designs, scale-up 5 liter bioreactor, analysis molecular weight at different cultivation times, levels induction interleukin-8 synthesis are described this study. In order to improve certify the...

A kinetic model for xylose catabolism in Aspergillus is proposed. From a thermodynamic analysis it was found that the intermediate xylitol will accumulate during catabolism. Use of allowed metabolic control (MCA) catabolic pathway to be carried out, and flux shown dependent on metabolite levels. Due constraints, may reside at first step pathway, i.e., reductase, even when intracellular concentration high. On basis analysis, general dogma specifying often resides following an present high...

The serine protease of Bacillus sp. C-4 has been reported as candidate proteases in the degumming process silk industry. optimization production by C4 was carried out using two-level fractional factorial and central composite designs. investigation followed laboratory pilot-scale molasses batch fed-batch bioreactors to reduce cost. highest activity observed (1546.5 U/mL, equivalent 34.4 U/mL/h) a 5-L bioreactor obtained under fermentation compared with process. subsequently scaled up 300-L...

To investigate the effects of dietary supplementation with different levels and molecular weights fungal β-glucan on productive performances, health, carcass traits meat quality in broilers. Two hundred ten one-day-old chicks equal sex were assigned to seven experimental groups 2×4 factorial arrangement. These supplemented (0, 10, 30 60 ppm) weight 1-3, 1-6 (low or high). High (H: 943 kDa) was obtained from Ophiocordyceps dipterigena BCC 2073, whereas H -Irradiation treatment performed...

Phomalactone, an antibacterial, insecticidal, and herbicidal compound, was produced by insect pathogenic fungi, Ophiocordyceps communis BCC 1842 2763, in bioreactors using different carbon nitrogen sources. Glucose fructose were preferable for growth phomalactone production. The highest specific rate (μ) of 0.012 hr−1, the biomass yield (Ysx) 0.38 g DW g−1 sugar, volumetric sugar consumption (qs) 0.036 (L hr)−1, maximum concentration () 93.30 mg L−1 at 127 hr, production (qp) 0.46 ± 0.12...

Vip3A (vegetative insecticidal protein) is a representative member of the Vip3 family, which widely used for lepidopteran pest control. This protein, non-growth-associated an effective bioinsecticide against insect pests, but there relatively little information about its production processes at large scales. Hence, effects environmental factors on by Bacillus thuringiensis Bt294 (antifoam agents, shaking speeds, agitation and aeration rates), as well controlling physical conditions such...

Cordycepin is one of the most important bioactive compounds; low productivity and long production cycle cordycepin are barriers to its commercialization. The optimal media for by Cordyceps militaris BCC 2819 cicadae 19788, which potent cordycepin-producing-fungal strains, were determined through statistical experiments. Six nutrients including glucose, adenine, glycine, alanine, casein hydrolysate vitamin solution found influence C. 2819, while same factors 19788 except glucose that was...

The potential of using a fungal exopolysaccharide produced by Ophiocordyceps dipterigena BCC 2073, as prebiotic in broiler chicken diet supplementing the at different concentrations (0-120 g/25 kg feed) was evaluated over period 42 days. Intestinal microbial populations faeces were identified. effects combination pre- and pro-biotic supplements also studied combining with Lactobacillus acidophilus 13938. Total Lactobacilli sp. counts faecal samples chickens fed containing both L. 13938...

Optimization of exopolysaccharides (EPS) produced by three strains entomopathogenic fungi (Beauveria bassiana BCC 2692, Ophiocordyceps dipterigena 2073, and Paecilomyces tenuipes 2656) was carried out together with analyses their prebiotic properties. B. 2692 6.27±0.22 g/L EPS on optimal medium using two-level fractional factorial design 4.7 in bioreactor. productions O. 2073 were 13.2 41.2 shake flask bioreactor, respectively. For P. 2656, 1.47±0.21 28.1 bioreactor obtained. These...

Fragmentation of β-glucans secreted by the fungus

A vegetative insecticidal protein, Vip3A, is highly active against lepidopteran pests, which are the most important pests in tropical countries. An aspect of successful commercial production this bacterial insecticide development culture media that maximize titres protein and cost reduction. This study aimed to investigate optimize Vip3A by Bacillus thuringiensis Bt294 using statistical methods 3-step sequential approaches. The experimental design showed was maximized 300 mg/L when bacterium...

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