A5086218012- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Action Observation and Synchronization
- Motor Control and Adaptation
- Functional Brain Connectivity Studies
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Glioma Diagnosis and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Image Analysis Techniques
- Zebrafish Biomedical Research Applications
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
Rockefeller University
2023-2024
Howard Hughes Medical Institute
2023
Emory University
2020-2021
University of Waterloo
2013-2016
Collège de France
2012-2014
Centre National de la Recherche Scientifique
2012-2014
Centre Interdisciplinaire de Recherche en Biologie
2014
Prompt execution of planned motor action is essential for survival. The interactions between frontal cortical circuits and the basal ganglia are central to goal-oriented selection initiation.1Graybiel A.M. ganglia.Curr. Biol. 2000; 10: R509-R511Abstract Full Text PDF PubMed Scopus (391) Google Scholar, 2Hikosaka O. Nakamura K. Sakai Nakahara H. Central mechanisms skill learning.Curr. Opin. Neurobiol. 2002; 12: 217-222Crossref (664) 3Middleton F.A. Strick P.L. Basal cerebellar loops:...
The ventromedial (VM)/ventro-anterior-lateral (VAL) motor thalamus is a key junction within the brain circuits sustaining normal and pathologic control functions decision-making. In this area of thalamus, on one hand, inhibitory nigro-thalamic pathway provides main output from basal ganglia, and, other thalamo-cortical loops are involved in maintenance ramping preparatory activity before goal-directed movements. To better understand nigral impact thalamic activity, we recorded...
The loop structure of cortico-striatal anatomy in principle enables both descending (cortico-striatal) and ascending (striato-cortical) influences, but the factors that regulate flow information these loops are not known. We report low- high-gamma oscillations (∼50 ∼80 Hz, respectively) local field potential freely moving rats highly synchronous between infralimbic region medial prefrontal cortex (mPFC) ventral striatum (vStr). Strikingly, mPFC preceded those vStr, whereas low-gamma lagged...
Hippocampal place responses can be prospectively or retrospectively modulated by the animal's future prior trajectory. Two main hypotheses explain this. The “multiple-map hypothesis” switches between different maps for trajectories (rate remapping). In contrast, in “buffer hypothesis,” hippocampus encodes an ongoing representation that includes recent past and/or impending choice. This study examines distribution of prospective and retrospective distributed along a common path continuous...
Abstract Place‐selective activity in hippocampal neurons can be modulated by the trajectory that will taken immediate future (“prospective coding”), information could useful neural processes elaborating choices route planning. To determine if and how prospective participate decision making, we measured time course of evolution recording place responses rats performing a T‐maze alternation task. After five or seven trials, routine was unpredictably interrupted photodetector‐triggered visual...
Background: Precise localization of intracerebral implants in rodent brains is required for physiological and behavioral studies, particularly if targeting deep brain nuclei. Traditional histological methods, based on manual estimation through sectioning can introduce errors complicate data interpretation. Methods: Here, we an alternative method recent advances tissue-clearing techniques light-sheet fluorescence microscopy. This uses a simplified recipe the Clear, Unobstructed Brain/Body...
ABSTRACT The nigro-thalamic pathway is one of the main outputs from basal ganglia, known to be involved in action selection, learning motor skills, and/or control vigor actions. However, specific function nigral input thalamus remains unclear. Using a combination vivo electrophysiological recordings thalamic neurons and optogenetic activation inputs behaving head-fixed mice, we determined that this primarily proper timing release goal directed At behavioral level, were able reduce amount...
Determining the localization of intracerebral implants in rodent brain stands as a critical final step most physiological and behaviroral studies, especially when targeting deep nuclei. Conventional histological approaches, reliant on manual estimation through sectioning slice examination, are error-prone, potentially complicating data interpretation. Leveraging recent advances tissue-clearing techniques light-sheet fluorescence microscopy, we introduce method enabling virtual slicing any...