A5102722284- Security and Verification in Computing
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Advanced Memory and Neural Computing
- Physical Unclonable Functions (PUFs) and Hardware Security
- Web Application Security Vulnerabilities
- Interconnection Networks and Systems
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Influenza Virus Research Studies
- Respiratory viral infections research
- Advanced Data Storage Technologies
- Network Security and Intrusion Detection
- Viral Infections and Outbreaks Research
- Caching and Content Delivery
Wuhan University
2022-2025
State Key Laboratory of Virology
2022
With the emergence and proliferation of microarchitectural attacks targeting branch predictors, once-established security boundary in computer systems architectures is facing unprecedented challenges. This paper introduces an innovative predictor modeling methodology that abstractly characterizes 19 states 53 operations aiming to assist hardware designers addressing overlooked concerns during microarchitecture design phase. Building upon this discipline, we develop a symbolic execution-based...
Abstract Ebola virus (EBOV), one of the deadliest viruses, is cause fatal disease (EVD). The underlying mechanism viral replication and EBOV-related hemorrhage not fully understood. Here, we show that EBOV VP35, a cofactor RNA-dependent RNA polymerase, binds human A kinase interacting protein (AKIP1), which consequently activates (PKA) PKA-downstream transcription factor CREB1. During infection, CREB1 recruited into ribonucleoprotein complexes in inclusion bodies (VIBs) employed for...
Abstract The SARS‐CoV‐2 spike (S) protein, a trimeric structure comprising three receptor binding domains (RBDs) and N‐terminal (NTDs), undergoes substantial conformational changes to fusion‐prone open state for angiotensin‐converting enzyme 2 (ACE2) host cell infection. Stabilizing its closed is key antiviral strategy but remains challenging. Here, we introduce S416, novel amphipathic molecule acting as “molecular bolt”. Cryo‐EM study reveals that S416 binds concurrently six sites across...
Viral immunosuppression substantially affects the host immune response of infected patients and protective efficacy vaccines. Here, we found that spike (S) protein, major vaccine antigen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), strongly suppresses innate immunity by inhibiting interferon-stimulated gene (ISG) expression through both S1 S2 subunits. Mechanistically, S protein inhibited formation classic factor 3 (ISGF3) complex composed STAT1, STAT2, IRF9 competing with...
Abstract As the world continues to experience COVID-19 pandemic, seasonal influenza remain a cause of severe morbidity and mortality globally. Worse yet, coinfection with SARS-CoV-2 A virus (IAV) leads more clinical outcomes. The development combined vaccine against both is thus high priority. Based on our established lipid nanoparticle (LNP)-encapsulated mRNA platform, we developed characterized novel encoding HA antigen (H1N1) virus, termed ARIAV. Then, ARIAV was ARCoV, which encodes...
The frontend of modern Intel processors will decode instructions into <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula> ops and stream them to the backend by bus, which is shared between two logical cores maximize utilization without sharing mechanism fully disclosed. Taking Haswell as an example, we reverse bus from Decoded ICache Instruction Decode Queue backend. We find that they are dynamically cores, makes it possible for observable timing differences in one...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may keep patients in a clinically asymptomatic state by blocking cellular innate antiviral immunity, but the molecular mechanism remains unclear. Here, we screened viral proteins of SARS-CoV-2 and found that spike (S) protein inhibits activation interferon-stimulated genes (ISGs) even reduces expression these to below background values. Mechanistically, S interacted with STAT1, STAT2, IRF9 impedes phosphorylation...