A5081203519- Genetics, Aging, and Longevity in Model Organisms
- Spaceflight effects on biology
- Telomeres, Telomerase, and Senescence
- Heat shock proteins research
- Aging and Gerontology Research
- Skin Protection and Aging
- Biochemical effects in animals
- Nutrition, Genetics, and Disease
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Dietary Effects on Health
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Effects of Radiation Exposure
- Circadian rhythm and melatonin
- Advanced Glycation End Products research
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- Bone Metabolism and Diseases
- Pluripotent Stem Cells Research
- melanin and skin pigmentation
- Curcumin's Biomedical Applications
Aarhus University
2016-2025
Diponegoro University
2024
Shriram Institute for Industrial Research
2020
Danish Gas Technology Centre (Denmark)
2008-2010
Aarhus School of Architecture
2000
Harvard University Press
2000
Double Helix (United States)
2000
University of Namur
1996
Guru Nanak Dev University
1995
National Institute for Medical Research
1982-1985
Abstract Decreased bone formation is an important pathophysiological mechanism responsible for loss associated with aging and osteoporosis. Osteoblasts (OBs), originate from mesenchymal stem cells (MSCs) that are present in the marrow form colonies (termed colony-forming units-fibroblastic [CFU-Fs]) when cultured vitro. To examine effect of osteoporosis on MSC population, we quantified number MSCs their proliferative capacity Fifty-one individuals were studied: 38 normal volunteers (23 young...
Abstract Scope: Curcumin, a component of the spice turmeric, was tested for its potential hormetic anti‐aging effects as an inducer mild stress. Methods and results: Early passage young human skin fibroblasts treated with low doses curcumin (below 20 μM) showed time‐ concentration‐dependent induction heme oxygenase‐1 (HO‐1), followed by compensatory increase in glutathione‐ S ‐transferase activity, GSH levels GSH/GSSG ratio. These were preceded oxidative stress (increased reactive oxygen...
The phenomenon of hormesis is represented by mild stress-induced stimulation maintenance and repair pathways resulting in beneficial effects for the cells organisms. Anti-aging life-prolonging a wide variety so-called stressors, such as pro-oxidants, aldehydes, calorie restriction, irradiation, heat shock, hypergravity, have been reported. Molecular mechanisms due to different stresses are yet be elucidated, but there indications that relatively small individual hormetic become biologically...
Abstract The effects of repetitive mild heat shock (30 min, 41° C) on growth and various cellular biochemical characteristics human skin fibroblasts undergoing ageing in vitro were analysed. Human ceils not only tolerated more than 30 repeated shocks throughout their replicative lifespan, but also maintained several young cells until late life. Whereas the rates, population doubling cumulative levels achieved remained unaffected, age‐related changes morphology, cell size, cytoskeletal...
Abstract: Curcumin (diferuloylmethane), is a component of the yellow powder prepared from roots Curcuma longa (Zingiberaceae), also known as tumeric or turmeric. It widely cultivated and used food ingredient in tropical areas Asia Central America. Treatment mid‐passage human epidermal keratinocytes with curcumin resulted biphasic hormetic dose–response respect to proteasome activity. treatment (up 1 μM for 24 h) increased chymotrypsin‐like activity by 46% compared that untreated...
Accumulation of molecular damage and increased heterogeneity are hallmarks cellular aging. Mild stress-induced hormesis can be an effective way for reducing the accumulation damage, thus slowing down aging from within. We have shown that repeated mild heat stress (RMHS) has anti-aging effects on growth various other biochemical characteristics normal human skin fibroblasts keratinocytes undergoing in vitro. RMHS given to cells basal levels chaperones, reduced damaged proteins, stimulated...
Our studies have shown that zeatin, (6-[4-hydroxy-3-methyl-but-2-enylamino]adenine), a cytokinin plant growth factor, has gerontomodulatory, youth preserving and anti-aging effects on serially passaged human adult skin fibroblasts undergoing aging in vitro. There were no immediate negative or toxic terms of cell attachment, proliferation, survival, cytoskeletal organization, cellular by treatment with zeatin concentrations between 1 200 µM. During long-term treatment, cells could be...