A5081783960- Ion channel regulation and function
- Neuroblastoma Research and Treatments
- Nicotinic Acetylcholine Receptors Study
- Vagus Nerve Stimulation Research
- Neurological disorders and treatments
Universidade Estadual de Maringá
2018-2020
Acetylcholine (ACh) spillover from motor endplates occurs after neuronal firing bursts being potentiated by cholinesterase inhibitors (e.g., neostigmine). Nicotinic α7 receptors (α7nAChR) on perisynaptic Schwann cells (PSCs) can control ACh unknown mechanisms. We hypothesized that adenosine might be the gliotransmitter underlying PSCs-nerve terminal communication. Rat isolated hemidiaphragm preparations were used to measure (1) outflow of [3 H]ACh, (2) real-time transmitter exocytosis...
<b><i>Background/Aims:</i></b> In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A<sub>2A</sub> and muscarinic M<sub>1</sub> receptors in recovery neuromuscular tetanic depression caused by blockage high-affinity choline transporter (HChT) hemicholinium-3 (HC-3), a condition that mimics myasthenia-like condition. <b><i>Methods:</i></b> Rat diaphragm preparations were indirectly...