A highly selective, amiloride-sensitive, epithelial sodium channel from rat colon (rENaC), composed of three homologous subunits termed alpha, beta, and gamma rENaC, has been cloned by functional expression was proposed to mediate electrogenic reabsorption in aldosterone-responsive epithelia. To determine whether rENaC could account for absorption vivo, we studied the cellular localization messenger RNA situ hybridization their subcellular distribution immunocytochemistry kidney, colon,...

Axonin-1 is a neuronal glycoprotein occurring both as membrane-bound and secreted form. Membrane-bound axonin-1 predominantly located in membranes of developing nerve fiber tracts has recently been characterized cell adhesion molecule; the soluble form from axons accumulates cerebrospinal fluid vitreous eye. In present study, we addressed question to whether was released functionally competent found that it strongly promotes neurite outgrowth when presented neurons an immobilized substratum....

The electrodeposition of polyaniline films is usually carried out in acid solutions such as hydrochloric acid, perchloric or sulfuric and more rarely organic acids camphorsulfonic (CSA). In this study, the impact presence a surfactant electrolytic solution based on CSA was evaluated by successively using anionic (sodium dodecyl sulfate, SDS), cationic (cetyltrimethylammonium bromide, CTAB), non-ionic (Tritonx100) surfactants. Whatever used, electrochemical oxidation aniline has successfully...

Conducting polymers such as poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) are increasingly used to interface electronics with biology. Their wettability, however, remains poorly understood. We show that the frequently-used sessile drop technique yields results strongly dependent on experimental conditions (measurement duration and relative humidity), due hydrogel-like behavior of PEDOT:PSS. In contrast, captive bubble a fully wet film overcomes these limitations. Dynamic...

Polyaniline (PANI) is a conducting polymer, widely used in gas-sensing applications. Due to its classification as semiconductor, PANI also detect reducing ammonia gas (NH3), which well-known and studied topic. However, easier, cheaper more straightforward procedures for sensor fabrication are still the subject of much research. In presented work, we describe novel, controllable, synthesis approach creating NH3 PANI-based receptor elements. The was electrochemically deposited via cyclic...

Abstract The discrimination of humidity in exhaled breath is utmost importance to turn analysis into an efficient noninvasive tool for early diagnosis or treatment monitoring several diseases. Herein, by assembling different ratios the conductive poly(3,4‐ethylenedioxythiophene): polystyrene sulfonate with polymer matrix polyethylene oxide (PEO), chemiresistor‐based sensors are designed and investigated. testing results display a broad relative detection range (6–92%), repeatability,...

Polyaniline (PAni)-based sensors are a promising solution for ammonia (NH

Aggressive angiomyxoma (AAM) is a rare tumor that preferentially involves the pelvis and perineal regions arises from connective tissue. Its cause pathogenesis are unknown at present. Treatment typically surgery, despite apparently complete resection, local recurrences common. We describe case of large left in 59-year-old woman who underwent two surgical excisions. The first had been done May 1998. She developed recurrence December A palliative resection with macroscopic residuals was...

Blends of poly(ethylene oxide) (PEO) with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) were investigated for the preparation electrically conductive films using melt-state extrusion processing techniques. High molecular weight PEO is selected as a melting carrier to enable PEDOT:PSS. A drop-casting technique from aqueous solutions first produce model PEO/PEDOT:PSS blends and identify influence relevant parameters on final electronic conductivity. low percolation...

Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase. Although some patients respond to VGB with significant seizure reduction, others do not. The aim of this study was identify possible responders before or in an early phase treatment measuring and homocarnosine contaminated macromolecules/creatine phosphocreatine ratio (GABA+/Cr) signal means proton-nuclear magnetic resonance (1H NMR)...

Hydrogen sulfide (H2S) gas poses a significant risk and thus demands continuous monitoring using reliable sensors. Chemiresistive sensors can serve this purpose, the utilization of conducting polymeric materials, particularly polyaniline (PAni), has demonstrated potential. To fabricate chemiresistors based on PAni, materials must be dispersed in an organic solvent like dimethylformamide (DMF), which several hazardous properties. Fortunately, dimethyl sulfoxide (DMSO) is safer alternative...

Ensuring indoor air quality (IAQ) is crucial for safeguarding health, with daily occupant activities serving as significant sources of pollutants. This study addresses the need to identify and mitigate pollution events caused by like cleaning cooking. Employing metal-oxide gas (MOX) sensors, we propose a method that automatically detects pollution-related through intrinsic dimensionality estimation on time-windowed multivariate signals. The approach was validated using dataset derived from...

Conducting polymers demonstrate an interesting ability to change their wettability at ultralow voltage (<1 V). While the conducting hydrogel poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS) is increasingly used as interface with biology partly thanks its mechanical properties, little known about electrical control of wettability. We rely on captive bubble technique study this property under relevant conditions (fully immerged). here report that variations PEDOT:PSS are...

The new antiepileptic drug vigabatrin (VGB) increases gamma‐aminobutyric acid (GABA) in the brain. We compared GABA+/Cr signals measured focus‐near and focus‐distant correlated it with degree of response to VGB. Brain were 17 epileptic patients structurally normal appearing tissue by nuclear proton magnetic resonance ( 1 H‐NMR) spectroscopy using a special editing sequence for GABA. In 11 measurements done brain areas distant focus six near focus. Full‐responders (seizure reduction ≥50% at...

Magnetic resonance spectroscopy (MRS) allows the assessment of chemical substances in living tissue and detection biochemical changes associated with certain diseases. In vivo MRS, however, is usually limited sensitivity spectral resolution. Many lines originating from metab olites interest are overlapped by signals other metabolites therefore not visible conventional MR spectra. order to overcome this limitation, three localized methods, a technique making use difference, multiple quantum...

Hybrid composites based on tin chloride and the conductive polymers, polyaniline (PAni) poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), were integrated into high-performance hydrogen sulphide (H2S) gas sensors working at room temperature. The morphology chemical properties studied by scanning transmission electron microscopy (SEM, TEM), energy dispersive spectroscopy (EDS) Fourier-transform infrared (FTIR). demonstrated a slightly porous nanostructure strong interactions...

In this study, we characterize the impact of electrical stimuli on wettability and volume thin films poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) in aqueous solution. At low voltage (<;1V), demonstrate a 20° to 30° modulation contact angle controlled by an electrowetting phenomenon not electrochemical reactions like usually seen for other common conducting polymers. Consequently, range can be tuned chemical functionalization its interface. Besides, show that polymer...