A5084205230- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- AI in cancer detection
- Metabolism, Diabetes, and Cancer
- Cancer Risks and Factors
- Digital Radiography and Breast Imaging
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Breast Cancer Treatment Studies
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- Youth Substance Use and School Attendance
- Chronic Disease Management Strategies
- Cardiovascular Health and Risk Factors
- Human Health and Disease
- Lipoproteins and Cardiovascular Health
- Nosocomial Infections in ICU
- Health Sciences Research and Education
- Inflammatory mediators and NSAID effects
- Colorectal Cancer Screening and Detection
- Health, Environment, Cognitive Aging
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- Ferroptosis and cancer prognosis
- Smoking Behavior and Cessation
Columbia University
2020-2024
Columbia University Irving Medical Center
2020-2024
Columbia College
2021-2024
Royal College of Physicians
2021-2024
University of Pennsylvania
2016-2019
Increasing usage of multigene panel testing has identified more patients with pathogenic or likely (P LP) variants in low-moderate penetrance genes uncertain significance (VUS). Our study evaluates the association between genetic test results and contralateral prophylactic mastectomy (CPM) among breast cancer.
Abstract Background U.S. professional organizations have provided conflicting recommendations on annual vs. biennial mammography screening. Potential harms of more frequent screening include increased anxiety and costs false positive results, including unnecessary breast biopsies overdiagnosis. Objective To characterize current practices beliefs surrounding frequency perspectives using risk-based to inform intervals. Design Semi-structured interviews informed by the Consolidated Framework...
Abstract Introduction: Approximately 5-10% of breast cancers are attributed to an inherited pathogenic variant (PV) in cancer predisposition genes, such as BRCA1 and BRCA2. Identifying women with hereditary syndromes is critical inform risk-appropriate screening prevention strategies. For example, contralateral prophylactic mastectomy (CPM) has been shown reduce the risk new primaries without a demonstrated survival benefit. In prior study, we found that pathogenic/likely (P/LP) variants...
19 Background: With FDA approval of PARP inhibitors for treatment BRCA1/2 -associated advanced breast, ovarian, pancreatic, and prostate cancer, National Comprehensive Cancer Network guidelines germline genetic testing (GGT) have expanded patients with these tumor types since 2019. We aimed to analyze factors associated GGT uptake in patient populations. Methods: conducted a retrospective cohort study among diagnosed metastatic breast cancer all stages ovarian pancreatic 2020-2023 at...
Abstract Introduction Current guidelines for cancer risk management hereditary breast focus on individuals with pathogenic/likely pathogenic variants (P/LP) in high penetrance genes. There is little consensus prophylactic mastectomy low/moderate genes or of uncertain significance (VUS). Furthermore, many enhanced screening are targeted to unaffected carriers, but not survivors. Given the increasing use multigene panel testing, more patients receiving results P/LP VUSs. We aimed investigate...
Background: Weight gain during chemotherapy for breast cancer is quite common and has a major impact on the quality of life.Post-treatment weight can also primary endpoints such as tumor recurrence overall survival.Parameters thought to include menopausal status, age regimen.Using meta-regression, we studied effect change by status regimen.Methods: Twenty-four studies were identified, extracted change, mean/median age, regimen.A meta-regression was performed using random-effects model high...
Abstract Introduction: Weight gain has a major impact on the quality of life breast cancer patients. Post treatment weight can primary endpoints such as recurrence, death, self identity and ability to return work. Parameters thought include menopausal status, age chemotherapy regimen. Using meta-regression, we studied effect change, by status Methods: 24 studies were identified, extracted for mean/median age, A meta-regression was performed, using random-effects DerSimonian Laird model high...
1569 Background: The role of biguanide Metformin, a first-line oral hypoglycemic agent, as cancer prevention agent has been controversial. In breast (BC) patients, few cohort studies have carefully examine the long-term impact metformin use both before and after diagnosis on patient outcomes. Methods: We examined association between pattern clinical outcomes 1215 patients (median f/u 66.3 months), who underwent primary surgery at our institution 1997 2013. total, 97 had recorded (B) (A) BC...
Abstract Introduction Annual mammography screening is recommended for women diagnosed with breast cancer the early detection of local recurrence and new primaries. Younger have higher density, which lowers sensitivity detection. The American Cancer Society recommends MRI as an adjunct to known hereditary syndromes. However, there insufficient evidence on use or ultrasound among young a personal history cancer. Our objective was investigate factors associated supplemental patients impact...
Abstract Background: Accurate assessment of a woman’s individualized breast cancer risk is necessary to inform shared decision-making regarding screening and risk-reducing strategies. Recently, deep learning techniques, including convolutional neural networks (CNN), have shown better predictive potential for compared mammographic density (MD). We evaluated whether combining clinical factors in the Breast Cancer Surveillance Consortium (BCSC) model, MD, with novel CNN-based evaluation more...
Abstract Background: Chemoprevention with anti-estrogens such as tamoxifen has been shown to lower mammographic density (MD), a strong predictor of breast cancer risk. However, measurement MD is limited by variability in radiologists’ interpretations. We developed novel, fully-automated convolutional neural network (CNN)-derived evaluation that more accurate risk than MD. evaluated whether chemoprevention associated significant change CNN among women atypical hyperplasia (AH), lobular or...
530 Background: The standard of care for early-stage hormone receptor (HR)-positive breast cancer (BC) is 5-10 years adjuvant endocrine therapy (ET), which leads to a 50-60% relative risk reduction in BC recurrence. However, 10-40% patients may relapse up 20 (y) after diagnosis, and there need biomarkers response ET. We developed novel, fully-automated convolutional neural network (CNN)-based mammographic evaluation that accurately predicts risk, being evaluated as pharmacodynamic biomarker...