A5018865401- Advanced biosensing and bioanalysis techniques
- DNA and Biological Computing
- Photochromic and Fluorescence Chemistry
- Metalloenzymes and iron-sulfur proteins
- Metal-Catalyzed Oxygenation Mechanisms
- Molecular Sensors and Ion Detection
- Molecular Communication and Nanonetworks
- Nitric Oxide and Endothelin Effects
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Machine Learning in Materials Science
- Crystallization and Solubility Studies
- Industrial Gas Emission Control
- Sulfur Compounds in Biology
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Molecular Junctions and Nanostructures
- Inorganic Fluorides and Related Compounds
- X-ray Diffraction in Crystallography
- Advanced Memory and Neural Computing
- Modular Robots and Swarm Intelligence
- Hemoglobin structure and function
- Photoreceptor and optogenetics research
Brown University
2019-2023
John Brown University
2021
Providence College
2021
Worcester Polytechnic Institute
2019
Multicomponent reactions enable the synthesis of large molecular libraries from relatively few inputs. This scalability has led to broad adoption these by pharmaceutical industry. Here, we employ four-component Ugi reaction demonstrate that multicomponent can provide a basis for large-scale data storage. Using this combinatorial chemistry encode more than 1.8 million bits art historical images, including Cubist drawing Picasso. Digital is written using robotically synthesized products, and...
Abstract Acid-base reactions are ubiquitous, easy to prepare, and execute without sophisticated equipment. Acids bases also inherently complementary naturally map a universal representation of “0” “1.” Here, we propose how leverage acids, bases, their encode binary information perform processing based upon the majority negation operations. These operations form functionally complete set that use implement more complex computations such as digital circuits neural networks. We present building...
Molecular data systems have the potential to store information at dramatically higher density than existing electronic media. Some of first experimental demonstrations this idea used DNA, but nature also uses a wide diversity smaller non-polymeric molecules preserve, process, and transmit information. In paper, we present general framework for quantifying chemical memory, which is not limited polymers extends mixtures all types. We show that theoretical limit molecular two orders magnitude...
Photocaged complexes can control the availability of metal ions to interrogate cellular signaling pathways. We describe a new photocage, {bis[(2-pyridyl)methyl]amino}(9-oxo-2-xanthenyl)acetic acid (XDPAdeCage, 1), which utilizes 2-xanthone acetic group mediate photodecarboxylation reaction. XDPAdeCage photolyzes with quantum yield 27%, and binds Zn2+ 4.6 pM affinity, decreases by over 4 orders magnitude after photolysis. For comparison our previous approach release via photodecarboxylation,...
Autocatalysis is fundamental to many biological processes, and kinetic models of autocatalytic reactions have mathematical forms similar activation functions used in artificial neural networks. Inspired by these similarities, we use an reaction, the copper-catalyzed azide-alkyne cycloaddition, perform digital image recognition tasks. Images are encoded concentration a catalyst across array liquid samples, classification performed with sequence automated fluid transfers. The outputs...
Iron–sulfur clusters (Fe–S) have been well established as a target for nitric oxide (NO) in biological systems. Complementary to protein-bound studies, synthetic models provided platform study what iron nitrosylated products and byproducts are produced depending on controlled reaction environment. We previously shown model [2Fe-2S] system that dinitrosyl complex (DNIC) upon nitrosylation along with hydrogen sulfide (H2S), another important gasotransmitter, the presence of thiol, hypothesized...
MitoNEET, a key regulatory protein in mitochondrial energy metabolism, exhibits uniquely ligated [2Fe–2S] cluster with one histidine and three cysteines. This unique has been postulated to sense the redox environment release Fe–S cofactors under acidic pH. Reported herein is synthetic system that shows how clusters react protons rearrange their coordination geometry. The low-temperature stable, site-differentiated [Fe2S2(SPh)3(CF3COO)]2– [Fe2S2(SPh)3(py)]− have prepared via controlled...
Photocaged complexes have demonstrated efficacy as tools to control the availability of bioactive metals in cells interrogate signaling pathways. We describe synthesis two new photocages, {bis[(2-pyridyl)methyl]amino}(9-oxo-2-xanthenyl)acetic acid (XDPAdeCage, 1 ) {bis[(2-pyridyl)methyl]amino}(m-nitrophenyl)acetic (DPAdeCage, 2 ), which utilize a 4-xanthone acetic and meta -nitrobenzyl chromophore respectively, mediate photodecarboxylation reaction. Both photocages strongly coordinate Zn 2+...
Chemical mixtures can be leveraged to store large amounts of data in a highly compact form and have the potential for massive scalability owing use large-scale molecular libraries. With parallelism that comes from having many species available, chemical-based memory also provide physical substrate computation with increased throughput. Here, we represent non-binary matrices chemical solutions perform multiple matrix multiplications additions, parallel, using reactions. As case study,...
Photocaged complexes have demonstrated efficacy as tools to control the availability of bioactive metals in cells interrogate signaling pathways. We describe synthesis two new photocages, {bis[(2-pyridyl)methyl]amino}(9-oxo-2-xanthenyl)acetic acid (XDPAdeCage, <b>1</b>) {bis[(2-pyridyl)methyl]amino}(m-nitrophenyl)acetic (DPAdeCage, <b>2</b>), which utilize a 4-xanthone acetic and <i>meta</i>-nitrobenzyl chromophore respectively, mediate...
Molecular data systems have the potential to store information at dramatically higher density than existing electronic media. Some of first experimental demonstrations this idea used DNA, but nature also uses a wide diversity smaller non-polymeric molecules preserve, process, and transmit information. In paper, we present general framework for quantifying chemical memory, which is not limited polymers extends mixtures all types. We show that theoretical limit molecular two orders magnitude...