Leonard W. Sprague

ORCID: 0000-0003-1926-8827
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About
Contact & Profiles
Research Areas
  • Enzyme Catalysis and Immobilization
  • 2D Materials and Applications
  • Analytical Chemistry and Chromatography
  • Microbial Metabolic Engineering and Bioproduction
  • Water Quality Monitoring and Analysis
  • Advanced Thermoelectric Materials and Devices
  • Various Chemistry Research Topics
  • Heusler alloys: electronic and magnetic properties
  • Chemical Synthesis and Analysis
  • Electrochemical Analysis and Applications
  • DNA and Biological Computing
  • Advanced biosensing and bioanalysis techniques

Brown University
2019-2020

Multicomponent reactions enable the synthesis of large molecular libraries from relatively few inputs. This scalability has led to broad adoption these by pharmaceutical industry. Here, we employ four-component Ugi reaction demonstrate that multicomponent can provide a basis for large-scale data storage. Using this combinatorial chemistry encode more than 1.8 million bits art historical images, including Cubist drawing Picasso. Digital is written using robotically synthesized products, and...

10.1038/s41467-020-14455-1 article EN cc-by Nature Communications 2020-02-04

Introducing chemical equilibrium concepts in undergraduate general chemistry promotes improved understanding of reactions. We have developed an engaging laboratory experiment exploring the cobalt complexation alcohols using UV–vis spectroscopy and successfully implemented a large class 378 students at Brown University. The octahedral to tetrahedral (pink blue) complex transition generates vivid visualizations, increasing students' interest learning. constants can be measured absorption...

10.1021/acs.jchemed.9b00264 article EN Journal of Chemical Education 2019-12-31

A majority of the electricity currently generated is regrettably lost as heat. Engineering high-efficiency thermoelectric materials which can convert waste heat back into therefore vital for reducing our energy fingerprint. ZT, a dimensionless figure merit, acts beacon promising materials. However, engineering with large ZT values practically challenging, since maximizing requires optimizing many interdependent material properties. Motivated by recent studies on bulk indium selenide that...

10.1021/acs.jpcc.9b05681 article EN The Journal of Physical Chemistry C 2019-10-08

10.1109/tbtr1.1969.299413 article EN IEEE Transactions on Broadcast and Television Receivers 1969-10-01
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