A5001652926- Developmental Biology and Gene Regulation
- Planarian Biology and Electrostimulation
- Pluripotent Stem Cells Research
- Congenital heart defects research
- Reconstructive Surgery and Microvascular Techniques
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Congenital limb and hand anomalies
- Linguistics and Education Research
- Epigenetics and DNA Methylation
- Osteoarthritis Treatment and Mechanisms
- Environmental Science and Water Management
- Marine Ecology and Invasive Species
- Neurogenesis and neuroplasticity mechanisms
- dental development and anomalies
- Physiological and biochemical adaptations
- Cephalopods and Marine Biology
- Cleft Lip and Palate Research
- Wnt/β-catenin signaling in development and cancer
- Ocean Acidification Effects and Responses
- Gender, Sexuality, and Education
- Craniofacial Disorders and Treatments
- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- Chromosomal and Genetic Variations
University Hospital Carl Gustav Carus
2023-2024
TU Dresden
2020-2024
Paul Langerhans Institute Dresden
2023
Instituto Gulbenkian de Ciência
2013-2020
Humans and other tetrapods are considered to require apical-ectodermal-ridge (AER) cells for limb development, AER-like suggested be re-formed initiate regeneration. Paradoxically, the presence of AER in axolotl, a primary model organism regeneration, remains controversial. Here, by leveraging single-cell transcriptomics-based multi-species atlas, composed human, mouse, chicken, frog cells, we first establish that axolotls contain with characteristics. Further analyses spatial...
The activity of ion channels and transporters generates ion-specific fluxes that encode electrical and/or chemical signals with biological significance. Even though it is long known some those are crucial for regeneration, only in recent years the corresponding molecular sources started to be identified using mainly invertebrate or larval vertebrate models. We used adult zebrafish caudal fin as a model investigate which how affect regeneration an model. Through combined use biophysical...
The mandible plays an essential part in human life and, thus, defects this structure can dramatically impair the quality of patients. Axolotls, unlike humans, are capable regenerating their lower jaws; however, underlying mechanisms and similarities to those limb regeneration unknown. In work, we used morphological, histological transcriptomic approaches analyze lateral resection axolotl mandible. We found that regenerate all missing tissues 90 days through gap minimization, blastema...
Abstract The mandible plays an essential part in human life and, thus, defects this structure can dramatically impair the quality of patients. Axolotls, unlike humans, are capable regenerating their lower jaws; however, underlying mechanisms and similarity to those limb regeneration unknown. In work, we used morphological, histological, transcriptomic approaches analyze lateral resection axolotl mandible. We found that regenerate all missing tissues 90 days through gap minimization, blastema...
Mechanical forces provide important signals for normal cell function and pattern formation in developing tissues, their role has been widely studied during embryogenesis pathogenesis. Comparatively, little is known of these animal regeneration. The axolotl an model organism the study regeneration, given its ability to fully restore many organs tissues after injury, including missing cartilage bone. Due crucial as main supporting tissue vertebrate body, regaining skeletal regeneration...
Abstract Humans and other tetrapods are considered to require apical-ectodermal-ridge, AER, cells for limb development, AER-like suggested be re-formed initiate regeneration. Paradoxically, the presence of AER in axolotl, primary regeneration model organism, remains controversial. Here, by leveraging a single-cell transcriptomics-based multi-species atlas, composed human, mouse, chicken, frog cells, we first established that axolotls contain with characteristics. Surprisingly, further...