The aim of the present study was to evaluate protective effect kaempferol against oxidative stress in streptozotocin (STZ)-induced diabetic rats.Diabetes induced male, adult albino rats Wistar strain, by intraperitoneal administration STZ (40 mg/kg body weight (BW)). Kaempferol (100 BW) or glibenclamide (600 µg/kg administered orally once daily for 45 days normal and STZ-induced rats.The showed significantly increased levels plasma glucose, thiobarbituric acid reactive substances, lipid...

To examine the effect of galangin on hyperglycemia-mediated oxidative stress in streptozotocin (STZ)-induced diabetic rats.Diabetes was induced by intraperitoneal administration low-dose STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 BW) or glibenclamide (600 µg/kg given orally, once daily for 45 days to normal and STZ-induced rats.Diabetic rats showed significantly increased levels plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides,...

Abstract Carvacrol (2‐methyl‐5‐(1‐methylethyl)‐phenol) is a predominant monoterpenic phenol which occurs in many essential oils of the family Labiatae including Origanum, Satureja, Thymbra, Thymus , and Corydothymus species. This study was designed to investigate hepatoprotective antioxidant properties carvacrol on d ‐galactosamine (D‐GalN)‐induced hepatotoxicity oxidative damage male albino Wistar rats. D‐GalN hepatotoxic rats exhibited elevation activities aspartate aminotransferase,...

Context: Galangin, a natural flavonoid, is found in honey and Alpinia officinarum Hance (Zingiberaceae). Galangin has antiviral, antimicrobial, antidiabetic anticancer properties, without side effects. The effects of galangin on hyperglycaemia lipid abnormalities are not known.Objective: To elucidate the effectiveness hyperglycaemia-associated complications changes rats with streptozotocin (STZ)-induced hyperglycaemia.Materials methods: Diabetes was induced adult Wistar by administering 40...

Exposure to ultraviolet B (UVB; 280-320 nm) radiation induces the formation of reactive oxygen species (ROS) in biological system. In this study, we examined protective effect carvacrol on UVB-induced lipid peroxidation and oxidative DNA damage with reference alterations cellular an-tioxidant status human lymphocytes. A series vitro assays (hydroxyl radical, superoxide, nitric oxide, DPPH (2,2-Diphenyl-1-picryl hydrazyl), ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) radical...

Context: Kaempferol is a flavonoid found in many edible plants (e.g. tea, cabbage, beans, tomato, strawberries, and grapes) or botanical products commonly used traditional medicine. Numerous preclinical studies have shown that kaempferol wide range of pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, neuroprotective, antidiabetic activities.

This context was investigated to assess the in vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme (ACE) inhibition traits of Punica granatum fruits peel extract. Initially, among various extracts tested, aqueous ethanolic depicted presence diverse phytoconstituents. In antioxidative properties were determined using standard methodologies. Results showed that had IC50 values 471.7 509.16 μg/mL, respectively terms 1,1,diphenyl 2,2,picrylhydrazyl scavenging....

The present study was designed to investigate the antihyperglycaemic effect of ethanolic extract Cardiospermum halicacabum Linn. (Sapindaceae) leaves on normal and streptozotocin (STZ) diabetic rats. Diabetes induced into male albino Wistar rats by intraperitonial administration STZ. leaf (CHE) administered orally at three different doses STZ-diabetic for 45 days. showed an increase in levels blood glucose glycosylated haemoglobin (HbA1c) a decrease insulin (Hb). In addition, significant...

Objective: We designed this study to observe the effect of galangin on damaged mitochondria in liver diabetic rats.Methods: Male albino Wistar rats were made by injecting streptozotocin (STZ) intraperitoneally (40 mg kg−1 body weight (BW)). Galangin (8 BW) or glibenclamide (600 µg was given orally daily once for 45 days both healthy and rats.Results: Diabetic showed significant (P < 0.05) increase mitochondrial oxidant [Thiobarbituric acid reactive substance (TBARS)] level a decrease...

Hibiscus rosasinensis, medicinal plant known for its various properties. The present study was to identify and characterize the flavonoid compound from petals of rosa sinensis. antioxidant compounds were isolated by Silica Gel G Column chromatography. From fractions, C5 shows highest activity compared C3 & C4 compounds. DNA damage protection results indicated that two major bands super coiled open circular protected presence different concentration (5 µg, 10 15 µg 20 µg) IR absorptions peaks...

Background: Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role pathology of myocardial infarction. Objective: The present study was designed to investigate antioxidant potential morin, flavonoid isoproterenol (ISO)-induced (MI), rats.Materials and Methods: Male albino Wistar rats were pre-treated with morin (40 mg/kg), daily for period 30 days. After treatment period, ISO (85 subcutaneously injected at interval 24 h 2days.Re s u l...

Bunch berry (Lantana camara) is primarily composed of flavonoids and vitamin C; therefore, it has been shown to possess various medical characteristics, including the ability relieve fever, inflammation, urinary tract infections.In this study, we intended assess twenty chosen constituents as potent inhibitory agents human acetylcholinesterase (hAchE), carbonic anhydrase II (hCA-II) carboxylesterase 1 (hCES-1) employing in silico techniques.The components were examined about docking behaviour...

To investigate the protective role of Cardiospermum halicacabum (C. halicacabum) leaf extract on glycoprotein metabolism in streptozotocin (STZ)-induced diabetic rats.Diabetes was induced male albino Wistar rats by intraperitonial administration STZ. The C. (CHE) administered orally to normal and STZ-diabetic for 45 days. effects plasma tissue glycoproteins (hexose, hexosamine, fucose sialic acid) were determined.The levels tissues containing hexose, hexosamine significantly increased...

The present study was designed to investigate the antihypertensive and antioxidant effect of Melothria maderaspatana leaf extract (MME) on sham-operated DOCA-salt (deoxycorticosterone acetate) induced hypertensive rats. Administration significantly increased systolic (from 127 212 mm Hg) diastolic 91 174 blood pressure compared control rats, while treatment with MME reduced 135 96 control. In plasma tissue concentration thiobarbituric acid reactive substances (TBARS) lipid hydroperoxide...

The present study reports the validation of cancer nanotherapy using proanthocyanidin (PAC). Nowadays, in vitro and vivo deliveries nanoparticle (NPs) drugs have been paid more attention, intensively. Moreover, current chemotherapeutic few first rate drawbacks including lack specificity requirement excessive drug doses. To overcome this problem chemotherapy, attainment high loading combination with degradable polymer nanoparticles (for instance,chitosan) is a trending research biology....

Galangin is a natural compound with anticancer, anti-inflammatory, and antioxidant properties. However, the ameliorating effect of streptozotocin (STZ)-induced glucose homeostasis has not yet been evaluated. Hence, this study was aimed at exploring role galangin in STZ-induced homeostasis, glycolytic gluconeogenic enzyme changes rats. STZ-treated rats were characterised by increased plasma glycosylated haemoglobin decreased insulin compared normal cage. Administration to effectively reversed...

Article Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in D-galactosamine-induced hepatotoxic rats was published June 1, 2008 the journal Journal Basic Clinical Physiology Pharmacology (volume 19, issue 2).