A5007489918- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Automotive and Human Injury Biomechanics
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Pregnancy and Medication Impact
- Neonatal and fetal brain pathology
- Renal Diseases and Glomerulopathies
- Gout, Hyperuricemia, Uric Acid
- Nuclear Receptors and Signaling
- Cardiac Arrest and Resuscitation
Perron Institute for Neurological and Translational Science
2018-2022
Curtin University
2018-2022
Children's Hospital at Westmead
2021
The University of Sydney
2021
Hunan Academy of Traditional Chinese Medicine
2008
Following mild traumatic brain injury (mTBI), the ionic homeostasis of central nervous system (CNS) becomes imbalanced. Excess Ca2+ influx into cells triggers molecular cascades, which result in detrimental effects. The authors assessed effects a combination ion channel inhibitors (ICI) following repeated mTBI (rmTBI). Adult female rats were subjected to two rmTBI weight-drop injuries 24 h apart, sham procedures (sham), or no (normal). Lomerizine, inhibits voltage-gated calcium channels, was...
Cellular responses at the sub-acute phase of mild traumatic brain injury (mTBI), and their contribution to ongoing damage, are unclear, complex require simultaneous assessment multiple cells elucidate. An 11-colour flow cytometry method for analysing was evaluated in a weight-drop rat model repeated mTBI. Animals received sham, one, two or three mTBI delivered 24 h intervals (n = 6/group). Cerebrum homogenates were prepared 11 days after first mTBI, cohorts n 3/group enable same-day staining...
Rett syndrome is a neurodevelopmental disorder caused by mutations of the methyl-CpG binding protein 2 gene. Abnormal physiological functions glial cells contribute to pathogenesis syndrome. Semaphorin 4D (SEMA4D) regulates processes central neuroinflammation and neurodegeneration including cytoskeletal structures required for process extension, communication, migration cells. Blocking SEMA4D-induced gliosis may preserve normal neuronal function rescue neurological dysfunction in We...
Abstract While it is well-established that bone responds dynamically to mechanical loading, the effects of mild traumatic brain injury (mTBI) on cranial composition are unclear. We hypothesized repeated mTBI (rmTBI) would change microstructure bones, without gross skull fractures. To address this, young adult female Piebald Viral Glaxo rats received sham, 1×, 2× or 3× closed-head mTBIs delivered at 24 h intervals, using a weight-drop device custom-built for reproducible impact. Skull bones...
ABSTRACT While it is well-established that bone responds dynamically to mechanical loading, the effects of mild traumatic brain injury (mTBI) on cranial composition are unclear. We hypothesized repeated mTBI (rmTBI) would change microstructure bones, without gross skull fractures. To address this, young adult female Piebald Viral Glaxo rats received sham, 1x, 2x or 3x closed-head mTBIs delivered at 24h intervals, using a weight-drop device custom built for reproducible impact. Skull bones...