A5077247005- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Health disparities and outcomes
- Trypanosoma species research and implications
- COVID-19 and Mental Health
- Homelessness and Social Issues
- Geriatric Care and Nursing Homes
- Parasites and Host Interactions
- Intergenerational Family Dynamics and Caregiving
- Global Health Care Issues
- Cardiac Arrest and Resuscitation
- S100 Proteins and Annexins
- Hip and Femur Fractures
- Research on Leishmaniasis Studies
University of Edinburgh
2024
Edinburgh Cancer Research
2024
Public Health England
2021
London School of Hygiene & Tropical Medicine
2021
The University of Western Australia
2017-2020
<sec> <title>BACKGROUND</title> Generation Scotland (GS) is a genetic family health cohort study established in 2006 (N~24,000). A new wave of recruitment was initiated 2022 aimed at adding further 20,000 participants to the using online data collection and remote saliva sampling (for genotyping DNA methylation profiling). Eligible individuals included anyone living aged over 12 years. New give consent for linkage their medical administrative records, provide sample DNA. The current...
Abstract Background Long-term care facilities (LTCF) worldwide have suffered high rates of COVID-19, reflecting the vulnerability persons who live there and institutional nature delivered. This study describes impact pandemic on incidences deaths in LTCF across England. Methods Laboratory-confirmed SARS-CoV-2 cases England, notified to Public Health England from 01 Jan 25 Dec 2020, were address-matched an Ordnance Survey reference database identify residential property classifications. Data...
Following mild traumatic brain injury (mTBI), further impacts can exacerbate negative outcomes. To compare chronic damage and deficits following increasing numbers of repeated mTBIs, a closed-head weight-drop model mTBI was used to deliver 1, 2 or 3 mTBIs adult female rats at 24 h intervals. Outcomes were assessed months the first mTBI. No gross motor, sensory reflex identified (p > 0.05), consistent with current literature. Cognitive function using Morris water maze revealed memory 1 2, but...
Following mild traumatic brain injury (mTBI), the ionic homeostasis of central nervous system (CNS) becomes imbalanced. Excess Ca2+ influx into cells triggers molecular cascades, which result in detrimental effects. The authors assessed effects a combination ion channel inhibitors (ICI) following repeated mTBI (rmTBI). Adult female rats were subjected to two rmTBI weight-drop injuries 24 h apart, sham procedures (sham), or no (normal). Lomerizine, inhibits voltage-gated calcium channels, was...
Abstract Background Peri-urban and urban settings have recently gained more prominence in studies on vector-borne transmission of Trypanosoma cruzi due to sustained rural-to-urban migrations reports infestations with triatomines. Prompted by the finding Triatoma infestans across gradient Avia Terai, an endemic municipality Argentine Chaco, we assessed selected components domestic risk order determine its variation gradient. Methods A baseline vector survey was conducted between October 2015...
Generation Scotland (GS) is a large family-based cohort study established as longitudinal resource for research into the genetic, lifestyle and environmental determinants of physical mental health. It comprises extensive sociodemographic clinical data from volunteers in Scotland.
Abstract Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake vaccination in this population have reported conflicting results. Using data from seven cohort (N = 325,298) included multinational COVIDMENT consortium, and Swedish registers 8,080,234), study investigates association between (defined using self-report measures, clinical diagnosis prescription data) uptake. Results were pooled meta-analyses, majority which showed...
Background: Persisting post-concussion symptoms (PPCS) is a complex, multifaceted condition in which individuals continue to experience the of mild traumatic brain injury (mTBI; concussion) beyond timeframe that it typically takes recover. Currently, there no way knowing may develop this condition. Method: Patients presenting hospital emergency department (ED) within 48 h sustaining mTBI underwent neuropsychological assessment and demographic, injury-related information blood samples were...
ABSTRACT Background Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake vaccination in this population have reported conflicting results. Therefore, we aimed to investigate association between and uptake, using data from five countries. Methods Data seven cohort (N=325,298), Swedish registers (8,080,234), were used identify uptake. Multivariable modified Poisson regression models conducted calculate prevalence ratio (PR) 95%...
<title>Abstract</title> <bold>Background:</bold> Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake vaccination in this population have reported conflicting results. Therefore, we aimed to investigate association between and uptake, using data from five countries. <bold>Methods:</bold> Data seven cohort (N=325,298), Swedish registers (8,080,234), were used identify uptake. Multivariable modified Poisson regression models...
Background: Care homes worldwide have suffered high rates of COVID-19, reflecting their inherent vulnerability and the institutional nature care delivered. This study describes impact pandemic in across England.Method: Laboratory confirmed SARS-CoV-2 cases England notified to PHE from 01 Jan 25 Dec 2020 were address-matched identify residential property classifications. Data analysed characterise clusters. Associated deaths defined as death within 60 days diagnosis or certified cause...