A5069676404- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Tissue Engineering and Regenerative Medicine
- Radiomics and Machine Learning in Medical Imaging
- Social Media in Health Education
- Birth, Development, and Health
- Neonatal and fetal brain pathology
- Preterm Birth and Chorioamnionitis
- Clinical practice guidelines implementation
- Lung Cancer Treatments and Mutations
- Immunodeficiency and Autoimmune Disorders
- Infant Development and Preterm Care
- Tracheal and airway disorders
- scientometrics and bibliometrics research
- COVID-19 diagnosis using AI
- Cancer Cells and Metastasis
- Traumatic Brain Injury Research
- Cancer Research and Treatments
- Restraint-Related Deaths
- Lipid metabolism and biosynthesis
- Laser Applications in Dentistry and Medicine
SUNY Upstate Medical University
2020-2025
Amgen (United States)
2024
Curtin University
2023
Perron Institute for Neurological and Translational Science
2023
Vanderbilt University Medical Center
2017-2019
The University of Western Australia
1983-2016
Brigham and Women's Hospital
2014-2015
Harvard University
2014-2015
Allegheny General Hospital
2015
AstraZeneca (United Kingdom)
2012
Maternal administration of corticosteroids is used to promote lung maturation in human infants considered at risk preterm delivery [1]. Randomised trials a single course corticosteroid treatment have indicated no adverse long-term neurological or cognitive sequelae [2–5]. However, the current trend many obstetric centres use repeated courses cases where birth has not eventuated, but persists 7 days beyond original [6–7]. This practice yet been subject randomised outcome. We examined effect...
Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer that occurs more frequently in men, but associated with longer survival women. Insight into the advantage of female patients may advance molecular understanding MPM and identify therapeutic interventions will improve prognosis for all patients. In this study, we performed whole-genome sequencing tumor specimens from 10 matched control samples to potential driver mutations underlying MPM. We identified differences gender...
The aim of this study was to validate a molecular expression signature [cell cycle progression (CCP) score] that identifies patients with higher risk cancer-related death after surgical resection early stage (I-II) lung adenocarcinoma in large patient cohort and evaluate the effectiveness combining CCP score pathological for predicting cancer mortality.Formalin-fixed paraffin-embedded tumor samples from 650 diagnosed I II who underwent definitive treatment without adjuvant chemotherapy were...
Abstract Background Few cohorts have study populations large enough to conduct molecular analysis of ex vivo lung tissue for genomic analyses. Transcriptome imputation is a non-invasive alternative with many potential applications. We present novel transcriptome-imputation method called the Lung Gene Expression and Network Imputation Engine ( LungGENIE ) that uses principal components from blood gene-expression levels in linear regression model predict tissue-specific gene-expression....
AMG 256 is a bi-specific, heteroimmunoglobulin molecule with an anti-PD-1 antibody domain and single IL-21 mutein on the C-terminus. Nonclinical studies in cynomolgus monkeys revealed that administration led to development of immunogenicity-mediated responses indicated could enhance anti-drug response directed toward monoclonal domain. Anti-AMG IgE were also observed monkeys. A first-in-human (FIH) study patients advanced solid tumors was designed these risks mind. elicited ADA 28 33...
A fatal nasopharyngeal malignant fibrous histiocytoma developed in a young male after irradiation of juvenile angiofibroma diagnosed 5 years earlier. The sarcoma extended from the nasopharynx into floor pituitary fossa and both parasellar regions. There was no clinical evidence any distant spread. Many cells contained cytoplasmic granular globular PAS‐positive inclusions shown to be alpha‐1‐antitrypsin immuno‐histochemically. Ultrastructurally, this probably corresponded electron‐dense...
Following mild traumatic brain injury (mTBI), further impacts can exacerbate negative outcomes. To compare chronic damage and deficits following increasing numbers of repeated mTBIs, a closed-head weight-drop model mTBI was used to deliver 1, 2 or 3 mTBIs adult female rats at 24 h intervals. Outcomes were assessed months the first mTBI. No gross motor, sensory reflex identified (p > 0.05), consistent with current literature. Cognitive function using Morris water maze revealed memory 1 2, but...
Traumatic injury to the central nervous system results in damage tissue beyond primary injury, termed secondary degeneration. Key events thought be associated with degeneration involve aspects of mitochondrial function which may modulated by red/near-infrared irradiation therapy (R/NIR-IT), but precisely how mitochondria are affected vivo has not been investigated. Secondary was modelled transecting dorsal aspect optic nerve adult rats and ultrastructure intact ventral vulnerable...
Maternal administration of corticosteroids is used to promote lung maturation in human infants considered at risk preterm delivery [1]. Randomised trials a single course corticosteroid treatment have indicated no adverse long-term neurological or cognitive sequelae [2–5]. However, the current trend many obstetric centres use repeated courses cases where birth has not eventuated, but persists 7 days beyond original [6–7]. This practice yet been subject randomised outcome. We examined effect...
Two fatal cases of sporadic herpes simplex virus (HSV) encephalitis were seen and diagnosed at the Sir Charles Gairdner Hospital, Perth, between 1979 1981. Necropsy studies directed to possible portal entry HSV into central nervous system. Viruses present in left olfactory nerve one patient. No viruses found Gasserian ganglia either The finding within an provides further evidence system human encephalitis.
Aims: A single course of prenatal corticosteroid reduces the mortality and morbidity preterm birth. Repeated courses corticosteroids are widely prescribed despite a lack safety data. delay myelination in ovine central nervous system at time delivery but with catch-up term. We aimed to evaluate their effect peripheral system.
Cutaneous larva migrans is caused by infection with hookworm larvae in tropical and sub-tropical areas. A history of recent travel to the tropics usually elicited. case cutaneous described which symptoms did not appear until five months after Tanzania. Although lesion may immediately, lie dormant for many presentation therefore occur a long time any foreign travel.
Adolescence is a critical period of postnatal development characterized by social, emotional, and cognitive changes. These changes are increasingly understood to depend on white matter development. White highly vulnerable the effects injury, including secondary degeneration in regions adjacent primary injury site which alters myelin ultrastructure. However, impact such alterations adolescent maturation yet be investigated. To address this, female piebald-virol-glaxo rats underwent partial...
Background: Antenatal corticosteroids (ACS) improve preterm neonatal outcomes. However, uncertainty remains regarding the safety of ACS exposure for developing fetus, particularly its neurosensory development. Objectives: We investigated effect single and multiple exposures on auditory nerve development in an ovine model pregnancy. Methods: Ewes with a fetus (gestational age [GA] 100 days) received intramuscular injection 150 mg medroxyprogesterone-acetate, followed by (i) betamethasone (0.5...
A single course of corticosteroid reduces intracranial hemorrhage in preterm infants. The mechanism protection is unclear. Glial fibrillary acidic protein (GFAP), expressed by astrocytes, regulated glucosteroids and an important component the cells forming blood brain barrier. We have evaluated effect prenatal upon ovine GFAP.Date-mated ewes were studied two protocols lambs delivered on day 125 or 145 (term = 150). In maternal injection protocol (n 36) administered saline, repeated...
Before using nanoparticles for therapeutic applications, it is necessary to comprehensively investigate nanoparticle effects, both in vitro and vivo. In the associated research article [1] we generate multimodal polymeric functionalized with an antibody, that are designed deliver anti-oxidant astrocytes. Here provide additional data demonstrating effects of preparations on indicator oxidative stress immortalized Müller cell line vitro. We use nanoscale secondary ion mass spectroscopy...
To develop an anthropomorphic diagnosis system of pulmonary nodules (PN) based on Deep learning (DL) that is trained by weak annotation data and has comparable performance to full-annotation systems.