A5089758824- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Advanced Neuroimaging Techniques and Applications
- S100 Proteins and Annexins
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Trauma and Emergency Care Studies
- Erythropoietin and Anemia Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Cannabis and Cannabinoid Research
- Eicosanoids and Hypertension Pharmacology
- Metabolism and Genetic Disorders
- Biomedical Text Mining and Ontologies
- Neuroscience of respiration and sleep
- Injury Epidemiology and Prevention
- Cardiovascular Effects of Exercise
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medical Research and Practices
- Resilience and Mental Health
- Bone and Joint Diseases
Curtin University
2021-2024
Perron Institute for Neurological and Translational Science
2022-2024
The University of Western Australia
2023-2024
Honeywell (United States)
2024
Mercy Fitzgerald Hospital
2024
Innovation Research Center
2021
Mercer University
2021
The University of Sydney
2018-2021
The Alfred Hospital
2010-2020
Monash University
2009-2020
Traumatic brain injury (TBI) resulting in poor neurological outcome is predominantly associated with diffuse damage and secondary hypoxic insults. Post-traumatic hypoxia known to exacerbate primary injury; however, the underlying pathological mechanisms require further elucidation. Using a rat model of traumatic axonal (TAI) followed by post-traumatic insult, we characterized pathology, macrophage/microglia accumulation, astrocyte responses over 14 days. Rats underwent TAI alone, 30 min (TAI...
Abstract Background The combination of diffuse brain injury with a hypoxic insult is associated poor outcomes in patients traumatic injury. In this study, we investigated the impact post-traumatic hypoxia amplifying secondary damage using rat model axonal (TAI). Rats were examined for behavioral and sensorimotor deficits, increased production inflammatory cytokines, formation cerebral edema, changes metabolism enlargement lateral ventricles. Methods Adult male Sprague-Dawley rats subjected...
The Australian Traumatic Brain Injury Initiative (AUS-TBI) aims to develop a health informatics approach collect data predictive of outcomes for persons with moderate-severe TBI across Australia. Central this is dictionary; however, no systematic reviews methods define and dictionaries exist to-date. This rapid review aimed identify characterize designing or variables in neurological conditions. Database searches were conducted from inception through October 2021. Records screened two stages...
Diffuse axonal injury is a common consequence of traumatic brain (TBI) and often co-occurs with hypoxia, resulting in poor neurological outcome for which there no current therapy. Here, we investigate the ability multifunctional compound erythropoietin (EPO) to provide neuroprotection when administered rats after diffuse TBI alone or post-traumatic hypoxia. Sprague–Dawley were subjected (TAI) followed by 30 minutes hypoxic (Hx, 12% O2) normoxic ventilation, recombinant human EPO-α (5000...
Abstract Cuprizone is a copper-chelating agent that induces pathology similar to within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease depends on the animals ingesting consistent doses cuprizone. Cuprizone-containing pelleted feed convenient way delivering cuprizone, but efficacy these pellets at demyelination has been questioned. This study compared degree between mice fed delivered in powdered formulation an early 3...
Abstract Reduced gray matter (GM) volume may represent a hallmark of major depressive disorder (MDD) neuropathology, typified by wide-ranging distribution structural alteration. In the study, we aimed to replicate and extend our previous finding profound widespread GM loss in MDD, evaluate diagnostic accuracy biomarker derived from an interconnected pattern across brain. sub-study International Study Predict Optimized Treatment Depression (iSPOT-D), two cohorts clinically defined MDD...
Abstract Exposure to repeated concussive traumatic brain injury (TBI) and blast-induced TBI has been associated with the potential development of neurodegenerative condition known as chronic encephalopathy (CTE). CTE is characterized by accumulation hyperphosphorylated tau protein, resultant tangles thought initiate cognitive behavioral manifestations that appear progresses. However, mechanisms linking blast hyperphosphorylation are unknown. Here we show single moderate TBI, mild all result...
Traumatic brain injury (TBI) is a complex disease in the most organ of body, whose victims endure lifelong debilitating physical, emotional, and psychosocial consequences. Despite advances clinical care, there no effective neuroprotective therapy for TBI, with almost every compound showing promise experimentally having disappointing results clinic. The highly interrelated innate immune responses govern both beneficial deleterious molecular consequences TBI are present as an attractive...
Objectives: People may experience a myriad of symptoms after mild traumatic brain injury (mTBI), but the relationship between and objective assessments is poorly characterized. This study sought to investigate association symptoms, resting heart rate (HR), exercise tolerance in individuals following mTBI, with secondary aim examine symptom-based clinical profiles recovery. Methods: Prospective observational adults aged 18 65 years who had sustained mTBI within previous 7 days. Symptoms were...
To determine profiles of serum ubiquitin carboxy-terminal hydrolase L1 and phosphorylated neurofilament heavy-chain, examine whether erythropoietin administration reduce their concentrations, biomarkers discriminate between placebo treatment groups.Single-center, prospective observational study.A sub-study the erythropoietin-traumatic brain injury clinical trial, conducted at Alfred Hospital, Melbourne, Australia.Forty-four patients with moderate-to-severe traumatic injury.Epoetin alfa...
We have previously demonstrated that traumatic brain injury (TBI) induces significant long-term neuronal hyperexcitability in supragranular layers of sensory cortex, coupled with persistent deficits. Hence, we aimed to investigate whether plasticity induced by environmental enrichment (EE) could attenuate abnormal and function post-TBI. TBI (n = 22) sham control 21) animals were randomly assigned housing either single or enriched conditions for 7-9 weeks. Then, terminal experiments,...
The health and well-being of retired rugby union league players, particularly regarding the long-term effects concussions, are major concern. Concussion has been identified as a risk factor for neurodegenerative diseases, such Alzheimer’s Amyotrophic Lateral Sclerosis (ALS), in athletes engaged contact sports. This study aimed to assess differences specific biomarkers between UK-based players with history concussion non-contact sports group, focusing on associated Alzheimer’s, ALS, CTE. We...
Traumatic brain injury (TBI) resulting from episodes of domestic violence (DV) is a serious yet greatly underreported issue. Head injuries arising in these circumstances are often concussive or sub-concussive nature, and unlikely to be isolated incidents, with victims frequently suffering repetitive TBIs over time. Although men may also DV, women children most at risk DV via intimate partners parents, respectively. Due the complexities interpersonal relationships, not always able receive...
In this series of eight articles, the Australian Traumatic Brain Injury Initiative (AUS-TBI) consortium describes approach used to select common data elements collected acutely that have been shown predict outcome following moderate-severe traumatic brain injury (TBI) across lifespan. This article presents unified single dictionary, together with additional measures chosen facilitate comparative effectiveness research and linkage. Consultations AUS-TBI Lived Experience Expert Group provided...
Phenylketonuria (PKU) is an autosomal recessive disorder whereby deficiencies in phenylalanine metabolism cause progressive neurological dysfunction. Managing PKU challenging, with disease monitoring focussed on short-term control rather than measures of neuronal damage. Conventional imaging lacks sensitivity, however diffusion kurtosis (DKI), a new MRI method may reveal subclinical white matter structural changes PKU. This cohort study involved adults recruited during routine clinical care....
Mild traumatic brain injury (mTBI) causes structural, cellular and biochemical alterations which are difficult to detect in the may persist chronically following single or repeated injury. Lipids abundant readily cross blood-brain barrier, suggesting that lipidomic analysis of blood samples provide valuable insight into neuropathological state. This study used liquid chromatography-mass spectrometry (LC-MS) examine plasma lipid concentrations at 11 days sham (no injury), one (1×) two (2×)...
Blast-induced neurotrauma (BINT) frequently occurs during military training and deployment has been linked to long-term neuropsychological neurocognitive changes, changes in brain structure. As personnel experience frequent exposures stress, BINT may negatively influence stress coping abilities. This study aimed determine the effects of on gray matter volume hormonal alteration. Participants were Canadian Armed Forces veterans with a history (n = 12), first responder controls 8), recruited...
Abstract Adaptability to stress is governed by innate resilience, comprised of complex neuroendocrine and immune mechanisms alongside inherited or learned behavioral traits. Based on their capacity adapt, some people thrive in stressful situations, whereas others experience maladaptation. In our study, we used state‐of‐the‐art tools assess the resilience level individuals, as well susceptibility developing military stress‐induced cognitive deficits. To address this question, tested Canadian...