A5010420085- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Insect and Arachnid Ecology and Behavior
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Plant Molecular Biology Research
- EEG and Brain-Computer Interfaces
- Receptor Mechanisms and Signaling
- Olfactory and Sensory Function Studies
- Neuroscience and Neural Engineering
- Animal Behavior and Reproduction
- Zebrafish Biomedical Research Applications
- Motor Control and Adaptation
- Sleep and Wakefulness Research
Weizmann Institute of Science
2013-2024
Janelia Research Campus
2019-2024
Howard Hughes Medical Institute
2019-2024
Helix (United States)
2022
Stanford University
2015
In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male...
Abstract Subdivisions of mouse whisker somatosensory thalamus project to cortex in a region-specific and layer-specific manner. However, clear anatomical dissection these pathways their functional properties during sensation is lacking. Here, we use anterograde trans-synaptic viral vectors identify three specific thalamic subpopulations based on connectivity with brainstem. The principal trigeminal nucleus innervates ventral posterior medial thalamus, which conveys whisker-selective tactile...
Mouse primary somatosensory barrel cortex (wS1) processes whisker sensory information, receiving input from two distinct thalamic nuclei. The first-order ventral posterior medial (VPM) nucleus most densely innervates layer 4 (L4) barrels, whereas the higher-order (medial part, POm) L1 and L5A. We optogenetically stimulated VPM or POm axons, recorded evoked excitatory postsynaptic potentials (EPSPs) in different cell-types across cortical layers wS1. found that neurons parvalbumin-expressing...
Abstract In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed...
In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male...
Layer 6b (L6b), the deepest neocortical layer, projects to cortical targets and higher-order thalamus is only layer responsive wake-promoting neuropeptide orexin/hypocretin. These characteristics suggest that L6b can strongly modulate brain state, but projections their influence remain unknown. Here, we examine inputs ex vivo in mouse primary somatosensory cortex with rabies-based retrograde tracing channelrhodopsin-assisted circuit mapping slices. We find receives its strongest excitatory...
Abstract Rodents continuously move their heads and whiskers in a coordinated manner while perceiving objects through whisker-touch. Studies head-fixed rodents showed that the ventroposterior medial (VPM) posterior (POm) thalamic nuclei code for whisker kinematics, with POm involvement reduced awake animals. To examine VPM coding head kinematics awake, head-free conditions, we recorded neuronal activity tracked movements male mice exploring an open arena. Using optogenetic tagging, found...
Animals actively move their sensory organs in order to acquire information. Some rodents, such as mice and rats, employ cyclic scanning motions of facial whiskers explore proximal surrounding, a behavior known whisking. Here, we investigated the contingency whisking kinematics on animal's behavioral context that arises from both internal processes (attention expectations) external constraints (available motor degrees freedom). We recorded rat at high temporal resolution 2 experimental...
Rats repeatedly sweep their facial whiskers back and forth in order to explore environment. Such explorative whisking appears be driven by central pattern generators (CPGs) that operate independently of direct sensory feedback. Nevertheless, can modulated feedback, it has been hypothesized some this modulation already occurs within the brainstem. However, interaction between feedback CPG activity is poorly understood. Using visual language statecharts, a dynamic, bottom-up computerized model...
Smell and touch convey most of the information that nocturnal rodents collect in their natural environments, each via its own complex network muscles, receptors neurons. Being active senses, a critical factor determining integration sensations relates to degree coordination. While it has been known for nearly 50 years sniffing whisking can be coordinated, dynamics such coordination dependency on behavioral environmental conditions are not yet understood. Here we introduce novel non-invasive...
Abstract Animals actively move their sensory organs in order to acquire information. Some rodents, such as mice and rats, employ cyclic scanning motions of facial whiskers explore proximal surrounding, a behavior known whisking. Here we investigated the contingency whisking kinematics on animal’s behavioral context that arises from both internal processes (attention expectations) external constraints (available motor degrees freedom). We recorded rat at high temporal resolution two...