A5020971015- Orthopedic Infections and Treatments
- Animal Behavior and Welfare Studies
- Clostridium difficile and Clostridium perfringens research
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Antimicrobial Resistance in Staphylococcus
- Orthopaedic implants and arthroplasty
- Animal health and immunology
- Total Knee Arthroplasty Outcomes
- Reliability and Agreement in Measurement
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Animal Nutrition and Physiology
- Animal Virus Infections Studies
- Veterinary Medicine and Surgery
- Osteomyelitis and Bone Disorders Research
- Infective Endocarditis Diagnosis and Management
- Probiotics and Fermented Foods
- Veterinary medicine and infectious diseases
- Bone fractures and treatments
University of Copenhagen
2017-2024
Glostrup Hospital
2021
Two chronic osteomyelitis patients, a diabetic foot patient and fracture-related infection patient, all with staphylococci-positive microbiology, were examined to confirm the clinical relevance of bacterial invasion submicron osteocyte lacuna-canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry light microscopy both Staphylococcus aureus epidermidis identified within OLCN four patients. The findings consolidate that is clinically relevant part disease biology, which from...
Pre-weaning diarrhea in mink, also known as "sticky kits", is a syndrome and outbreaks occur every year on commercial mink farms all producing countries. Morbidity mortality can be considerable farm with huge economic consequences for the farmer well compromised welfare kits. Although efforts have been taken to identify etiologic agents involved outbreaks, still regarded multifactorial recurring problems same draw attention management environmental risk factors. In pre-weaning period from...
Pre-weaning diarrhea (PWD) in mink kits is a common multifactorial syndrome on commercial farms. Several potential pathogens such as astroviruses, caliciviruses, Escherichia coli and Staphylococcus delphini have been studied, but the etiology of seems complex. In pooled samples from 38 diarrheic 42 non-diarrheic litters, each comprising intestinal contents 2-3 same litter, bacterial populations were studied using Illumina Next Generation Sequencing technology targeted 16S amplicon...
Pre-weaning diarrhea (PWD) in mink, also known as "sticky kits", is a frequently occurring syndrome suckling mink kits on commercial farms. Outbreaks of PWD result weakened kits, increased mortality and reduced growth welfare well considerable economic losses for the farmers. The regarded multifactorial with complex etiology, studies have focused associations environment, management dam characteristics. present study was conducted from May to June 2015 included 70 dams litters without PWD....
Abstract Staphylococcus delphini is one of the most common pathogens isolated from mink infections, especially dermatitis. Tylosin (TYL) used frequently against these although no evidence-based treatment regimen exists. This study aimed to explore dosage TYL for infections caused by S. in mink. Two animal experiments with a total 12 minks were conducted serum pharmacokinetic (PK) characteristics after 10 mg/kg IV and oral dosing, respectively. The concentration samples collected before eight...
ABSTRACT Clarification of the infection microbiology remains a challenge in pre-weaning diarrhea (PWD) syndrome farmed mink (Neovison vison). Duodenal, jejunal and colon sections from 36 kits with PWD were systematically examined by chromogen situ hybridization targeting two incriminated viruses: astrovirus sapovirus. Using RNAscope® 2.5 HD Duplex Assay, sapovirus visualized simultaneously demonstrated gut tissue. Both viruses infect enterocytes small intestine specific localization pattern;...
<title>Abstract</title> <bold>Background </bold>Prosthetic joint infections (PJI) are recalcitrant, hard-to-treat and severe complications of arthroplasty. Therefore, there is a need to develop new effective treatment strategies, animal models high clinical relevance needed. This study aimed detailed surgical protocol for inserting hip hemiarthroplasty in Göttingen minipig thorough post-mortem sampling pave the way creating PJI model. <bold>Methods </bold>Three adult female minipigs...
Prosthetic joint infections (PJI) are recalcitrant, hard-to-treat and severe complications of arthroplasty. Therefore, there is a need to develop new effective treatment strategies, animal models high clinical relevance needed. This study aimed detailed surgical protocol for hip hemiarthroplasty in Göttingen minipigs thorough post-mortem sampling pave the way creating minipig PJI model.
Aim The osteolytic process of osteomyelitis is, according to textbooks, caused by increased osteoclast activity due RANKL production osteoblasts. However, recent findings contradict this theory. Therefore, the aim was investigate, in a porcine model, how osteolysis is affected massive inflammation and blocking, respectively. In parallel, patients with chronic osteomyelitis, diabetes, foot fracture related infections (FRI) were included for advanced histological analysis osteolysis. Methods...
Veterinary telemedicine has only been adopted to some degree. One aspect that needs be evaluated is clinical examinations using video. The objective of this study was evaluate agreement between a traditional physical examination and recorded video finishing pigs with umbilical outpouchings (umbilical hernias, cysts, abscesses) as the unit. A total 102 finisher were clinically examined on Four experienced pig veterinarians allowed examine each for approximately 10 min individually asked fill...
Pre-weaning diarrhea (PWD) is a syndrome affecting farm-raised neonatal mink kits. Apart from it causes greasy skin exudation, dehydration, and distressed behavior can ultimately lead to death. No specific causative agents have been identified the regarded as multifactorial. The aim of present study was investigate possible inflammatory state in kits with PWD, indicated by raised serum concentrations acute phase protein amyloid A (SAA) changes intestinal pathomorphology contents bacteria....