A5070826012- Molecular Sensors and Ion Detection
- DNA and Nucleic Acid Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Supramolecular Chemistry and Complexes
- Lipid Membrane Structure and Behavior
- Analytical Chemistry and Sensors
- Radioactive element chemistry and processing
- Electrochemical Analysis and Applications
- Amino Acid Enzymes and Metabolism
- Advanced biosensing and bioanalysis techniques
- Crystallography and molecular interactions
- Luminescence and Fluorescent Materials
- Chemical Reaction Mechanisms
- Photochromic and Fluorescence Chemistry
- Lanthanide and Transition Metal Complexes
- Porphyrin and Phthalocyanine Chemistry
- Chemical Synthesis and Characterization
- Photoreceptor and optogenetics research
- Photosynthetic Processes and Mechanisms
- Drug Transport and Resistance Mechanisms
The University of Sydney
2020-2024
The development of colorimetric and fluorescent sensors continues apace. In this review, we highlight developments made in area from 2020 to 2022. review is structured by the different non-covalent interactions used bind anions addition covering photoswitchable systems, excimers molecular logic gates, arrays for anion sensing.
The liposomal membrane transport assay, which uses 8-hydroxypyrene-1,3,6-trisulfonic acid to monitor the internal pH of vesicles (the HPTS assay), is a widely used technique for analysing activity anionophore-facilitated across phospholipid membrane. This paper describes stepwise conduct this detailing both perks and pitfalls using method determine an anionophore mechanism.
Active transport of ions uphill, creating a concentration gradient across cell membrane, is essential for life. It remains significant challenge to develop synthetic systems that allow active uphill transport. Here, process fuelled by organometallic compounds reported creates pH gradient. The hydrolysis reaction Pt
Synthetic anion transporters provide a promising avenue to treat diseases like cystic fibrosis and cancer. Anion binding site preorganisation is one aspect of transporter design which can be manipulated enhance binding. Macrocycles possess preorganised cavities, enabling more stable, selective, efficient transport. In this study, we build on macrocyclic tetralactam scaffold by preparing series fluorinated non-fluorinated transporters. The macrocycles were functionalised with variety...
Synthetic anion transporters provide a promising avenue to treat diseases like cystic fibrosis and cancer. Anion binding site preorganisation is one aspect of transporter design which can be manipulated enhance binding. Macrocycles possess preorganised cavities, enabling more stable, selective, efficient transport. In this study, we build on macrocyclic tetralactam scaffold by preparing series fluorinated non-fluorinated transporters. transport assays were used analyse the substituent...
Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most exhibit an undesired side effect of facilitating proton via interacting with fatty acids present in the membrane. To address limitation, we here report use a new tetrapodal scaffold to maximize selective interaction spherical over binding carboxylate headgroup acids. One demonstrated high selectivity uniport acid-induced while being >10 times more active than...
A series of fluorescent coumarin-based bis-ureas have been synthesised. These compounds show strong HCl cotransport properties in model vesicle systems. Cellular localisation studies that cytotoxic compound 4 localises lysosomes and perturbs cellular pH.
Synthetic anion transporters show potential in treating life-threatening diseases like cystic fibrosis and cancer. However, with increasingly complex transporter architectures designed to control binding transport, it is important consider solubility deliverability during design. The fluorination of synthetic has been shown tune the lipophilicity, transport rates, strength. In this work, we expand on our previously reported tetrapodal (thio)urea a series fluorinated transporters. effects...
Abstract Active transport of ions uphill, creating a concentration gradient across cell membrane, is essential for life. It remains significant challenge to develop synthetic systems that allow active uphill transport. Here, process fuelled by organometallic compounds reported creates pH gradient. The hydrolysis reaction Pt II complexes results in the formation aqua established rapid transmembrane movement (“flip‐flop”) neutral Pt−OH species, leading protonation OH group inner leaflet,...
Synthetic anion transporters provide a promising avenue to treat diseases like cystic fibrosis and cancer. Anion binding site preorganisation is one aspect of transporter design which can be manipulated enhance binding. Macrocycles possess preorganised cavities, enabling more stable, selective, efficient transport. In this study, we build on macrocyclic tetralactam scaffold by preparing series fluorinated non-fluorinated transporters. transport assays were used analyse the substituent...
The vesicular anion transport activity assay, which uses 8-hydroxypyrene-1,3,6-trisulfonic acid to monitor the internal pH of vesicles (the HPTS assay), is a widely used technique for analysing anionophore facilitated across phospholipid membrane. This methods paper describes stepwise conduct this detailing both perks and pitfalls using method determine an mechanism.
The vesicular anion transport activity assay, which uses 8-hydroxypyrene-1,3,6-trisulfonic acid to monitor the internal pH of vesicles (the HPTS assay), is a widely used technique for analysing anionophore facilitated across phospholipid membrane. This methods paper describes stepwise conduct this detailing both perks and pitfalls using method determine an mechanism.
A series of fluorescent coumarin bis-ureas have been synthesised and their anion transport properties studied. The compounds function as highly potent HCl co-transport agents in lipid bilayer membranes.
The vesicular anion transport activity assay, which uses 8-hydroxypyrene-1,3,6-trisulfonic acid to monitor the internal pH of vesicles (the HPTS assay), is a widely used technique for analysing anionophore facilitated across phospholipid membrane. This methods paper describes stepwise conduct this detailing both perks and pitfalls using method determine an mechanism.
The vesicular anion transport activity assay, which uses 8-hydroxypyrene-1,3,6-trisulfonic acid to monitor the internal pH of vesicles (the HPTS assay), is a widely used technique for analysing anionophore facilitated across phospholipid membrane. This methods paper describes stepwise conduct this detailing both perks and pitfalls using method determine an mechanism.
A series of fluorescent coumarin bis-ureas have been synthesised and their anion transport properties studied. The compounds function as highly potent HCl co-transport agents in lipid bilayer membranes.