A5101767219- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
- Seaweed-derived Bioactive Compounds
- Cell death mechanisms and regulation
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Marine Sponges and Natural Products
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
Linyi People's Hospital
2015-2021
Beijing Institute of Genomics
2016
Chongqing Medical University
2010
Abstract HOTAIR (homeobox transcript antisense RNA), one of the prototypical long non-coding RNAs, has been verified overexpressed in multiple carcinomas and emerged as a promising novel anticancer target. Its well-established role is acting predictor poor prognosis promoting cancer cell metastasis. Recently, another important mission was uncovered that targeting caused apoptosis. Nevertheless, so far there no published data elaborating mechanism. Here, we report microRNA miR-125a-5p...
Abstract Objective To evaluate the expression of BCL-2 and BAD genes in tissues breast carcinoma investigate relationship between cancer cells with chemosensitivity. Methods Immunohistochemical technique was used to detect BCL-2, 10 normal tissues, fibroadenoma 40 youth human menopause tissues. And ER, PR 80 20 Surgical samples cancer, diagnosed by pathology, were obtained from The First Affiliated Hospital Chongqing Medical University. sample cultured separately incubator at 37°C, 5% CO 2...
The present study demonstrated the effect of fucoidan, isolated from Fucus vesiculosus, on cell growth and apoptosis in anaplastic thyroid cancer cells. viability was analyzed using a Cell Counting Kit‑8 proliferation kit. Diamidino-2-phenylindole terminal deoxynucleotidyl transferase-mediated dUTP nick‑end labeling assays were used to examine apoptotic which revealed presence bodies DNA fragmentation. Fucoidan inhibited FTC133 TPC1 ATC cells dose‑dependent manner. It also induced by...
Abstract Thyroid cancer (TC) was the most frequent thyroid malignant tumour, accounting for about 1% of all tumours. Some long non‐coding RNAs (lncRNAs) have been reported to exert essential tumour promotion effects, while caspase‐9 (CASP9) gene could play a promotive role in cell apoptosis TC. However, whether they specific effect on TC remains unclear. Hence, this study aims explore relationship between LINC00607 and CASP9, its expression tissues lines determined. Then, we explored...
Abstract Background: The aim of this study was to use the latest BeadChip technology obtain a genome-wide DNA methylation profile for cartilage from patients with primary knee osteoarthritis (OA), providing first comprehensive description changes in advanced OA. Methods: Cartilage tissues were taken after total arthroplasty and divided into eroded group intact according status. obtained using Infinium MethylationEPIC kit, which enables analysis >850,000 CpG sites. Comparisons two groups...