A5055132969- Pregnancy and preeclampsia studies
- Hemoglobinopathies and Related Disorders
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Maternal and fetal healthcare
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 Impact on Reproduction
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Pregnancy and Medication Impact
- Youth, Drugs, and Violence
- Cardiovascular Issues in Pregnancy
- Renal Diseases and Glomerulopathies
- Neurological Complications and Syndromes
- Gestational Diabetes Research and Management
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Pregnancy-related medical research
- Apelin-related biomedical research
- COVID-19 Clinical Research Studies
Universidade Federal de Minas Gerais
2016-2025
May Institute
2015
Although preeclampsia causes high maternal/fetal morbidity and mortality, the etiology of this multi-system disorder still remains to be elucidated. Herein, we have characterized cytokine plasma levels in severe preeclamptic women compared normotensive pregnant non-pregnant women, aiming better understand immunological network its clinical significance for pathogenesis severity preeclampsia. A total 219 were selected. The study population was composed three groups referred as preeclamptic,...
Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th week gestation. The aim of this study was to investigate whether platelet count (PC) indices (mean volume (MPV), distribution width (PDW), plateletcrit (PCT)) could predict severe form preeclampsia (sPE).Three groups were evaluated; G1-pregnant with sPE (N = 29); G2-normotensive pregnant 28) Group 3: non-pregnant women 30). Platelet parameters obtained using same automatic blood cells count. Statistical...
Background Despite intensive research, the etiopathogenesis of preeclampsia (PE) remains uncertain. Inflammatory and angiogenic factors are thought to play considerable roles in this disease. The objective study was investigate association between soluble endoglin (sEng), transforming growth factor beta-1 (TGF-β1) tumor necrosis alpha receptors (sTNF-Rs) clinical manifestations PE. Methods Plasma levels sEng, TGF-β1 sTNF-Rs were determined by ELISA 23 non-pregnant, 21 normotensive pregnant...
Brazilian Cohort Study of Preeclampsia: latent risks after pregnancy (PERLA-Brazil) are a retrospective cohort study including women with and without preeclampsia history, 6-15 years pregnancy, aiming to evaluate lipid profile, clinical parameters the frequency metabolic syndrome. A total 188 from Belo Horizonte (Brazil), who became pregnant between 2008 2017, were included: 86 PE history 102 normotensive pregnancy. The participants underwent an interview had blood samples collected 2022...
Preeclampsia (PE) is a multifactorial disease characterized by high blood pressure and proteinuria after the 20th week of pregnancy. PE associated with fibrin deposition in placental microcirculation intrauterine fetal growth retardation. We evaluated FVIII activity, VWF ADAMTS13 plasma levels, according to O "non O" groups, women severe (sPE).This case-control study included 140 women; 55 pregnant sPE, 35 normotensive 50 non-pregnant women. antigen levels were assessed ELISA (American...
Preeclampsia (PE) is characterized by hypertension and proteinuria. It has been classified in early or late according to gestational age at the onset of disease. Endothelial dysfunction plays a crucial part its pathogenesis. NO potent vasodilator ADMA endogenous inhibitor. We have assessed maternal levels. were increased [0.66 μmol/L] versus sPE [0.47 (P=0.001) normotensive pregnant [0.48 (P=0.001). Our findings suggest that high levels could compromise synthesis contributing endothelial...
There may be a relationship between endothelial dysfunction, coagulation activation and nitric oxide (NO) synthesis in women with mild severe preeclampsia (PE).Plasma thrombomodulin (TM), D-Dimer (D-Di), cyclic guanosine monophosphate (cGMP) placental synthase activity (NOS) were investigated 21 normotensive pregnant (G1), 22 PE (G2) 20 (G3).TM D-Di significantly increased G3 compared to G1 (P=0.001 P=0.006, respectively) G2 (P=0.001, both cases). However, there was no significant difference...
Omega-3 and omega-6 fatty acids can be endogenously converted into mediators with pro-inflammatory (eg, leukotriene B4/LTB4) or anti-inflammatory/pro-resolving activities resolvin D1/RvD1 maresin 1/MaR1). Recent data indicate an imbalance of LTB4 MaR1 levels in pre-eclampsia (PE), but the relative production these mediators, including RvD1, role disease pathogenesis remain unclear. Therefore, this study aimed to investigate plasma LTB4, pregnant women without PE non-pregnant controls their...
To examine whether the
Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.Methods: D-Di PAI-1 plasma were determined 28 at 12–19, 20–29, 30–34 35–40 weeks of gestation.Results: was lower 12–19 higher who developed PE versus did not develop it. increased both groups, peaking earlier pregnant PA1-1 across gestation, but it didn't differ between groups.Conclusion: able to discriminate these groups gestation.