A5101483329- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Virus-based gene therapy research
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Clostridium difficile and Clostridium perfringens research
- Animal Disease Management and Epidemiology
- Bacterial Genetics and Biotechnology
- Diet and metabolism studies
- Bacteriophages and microbial interactions
- Vaccine Coverage and Hesitancy
- Biochemical and Structural Characterization
- CRISPR and Genetic Engineering
- Herpesvirus Infections and Treatments
- Plant and Fungal Interactions Research
- Hepatitis B Virus Studies
- Antimicrobial Peptides and Activities
- Cytomegalovirus and herpesvirus research
- Viral Infectious Diseases and Gene Expression in Insects
- HIV Research and Treatment
- Plant Pathogens and Fungal Diseases
- RNA and protein synthesis mechanisms
- Influenza Virus Research Studies
First People's Hospital of Nanning
2025
Rutgers, The State University of New Jersey
2006-2024
Beijing Chest Hospital
2024
Capital Medical University
2024
Beijing Academy of Agricultural and Forestry Sciences
2013-2023
Institute of Quality Standards and Testing Technology for Agro Products
2023
University of Science and Technology of China
2006-2022
Shanghai Jiao Tong University
2008-2021
Guangxi Medical University
2021
Hefei National Center for Physical Sciences at Nanoscale
2009-2013
ABSTRACT Autoinducer 2 (AI-2) is widely recognized as a signal molecule for intra- and interspecies communication in Gram-negative bacteria, but its signaling function Gram-positive especially Staphylococcus aureus , remains obscure. Here we reveal the role of LuxS regulation capsular polysaccharide synthesis S. NCTC8325 show that AI-2 can regulate gene expression involved some physiological activities molecule. Inactivation luxS resulted higher levels transcription genes. The survival rate...
Staphylococcus aureus is an important pathogen that causes biofilm-associated infection in humans. Autoinducer 2 (AI-2), a quorum-sensing (QS) signal for interspecies communication, has wide range of regulatory functions both Gram-positive and Gram-negative bacteria, but its exact role biofilm formation S. remains unclear.Here we demonstrate mutation the AI-2 synthase gene luxS RN6390B results increased compared with wild-type (WT) strain under static, flowing anaerobic conditions mouse...
Although oxygen has been reported to regulate biofilm formation by several Shewanella species, the exact regulatory mechanism mostly remains unclear. Here, we identify a direct oxygen-sensing diguanylate cyclase (DosD) and reveal its role in putrefaciens CN32 under aerobic conditions. In vitro vivo analyses revealed that activity of DosD culminates synthesis cyclic (c-di-GMP) presence oxygen. regulates transcription bpfA operon which encodes seven proteins including large repetitive adhesin...
Osteoarthritis (OA) is a common joint degenerative disease. The current diagnosis of OA mainly through imaging and physical examination. Once such established, it means that the lesion often advanced, resulting in poor treatment effect. laboratory diagnostic indicators can be used as way to diagnose early, promote early detection, osteoarthritis. In this paper, we selected some representative clinical candidate biomarkers auxiliary review its significance, value research progress.
To investigate the diagnostic role of fibrin-related markers in perioperative venous thromboembolism (VTE). A total 100 high-risk patients, identified using Caprini thrombosis risk assessment model [46 with deep vein (DVT) and 54 pulmonary embolism (PE)], were included as study subjects. Additionally, 50 healthy volunteers undergoing medical checkups during same period served controls. The levels D-dimer, fibrin monomer (FM) degradation products (FDP) compared between patients control group...
Staphylococcus aureus is a major human pathogen, which has multiple drug resistance and can cause serious infections. Recent studies have shown that berberine antibacterial activity it affect biofilm formation of S. aureus. However, the effect on controversial. In this study, we investigate development in NCTC8325 explore possible mechanism. Susceptibility test shows inhibits growth methicillin-sensitive (MSSA), methicillin-resistant (MRSA) vancomycin-intermediate (VISA) at different...
Aims: Experiments were designed to detect quorum-sensing signals produced by Clostridium botulinum. Methods and Results: botulinum 56A cell-free supernatants obtained at the end of lag phase, mid-exponential phase early stationary growth assayed for bioluminescence in Vibrio harveyi assay system. Twelve 16-h culture induced auto-inducer 2 (AI-2) but not 1 (AI-1) assay. Intra-species quorum sensing was also as ability promote spore germination outgrowth a microtitre plate Spore populations...
ABSTRACT Heparosan serves as the starting carbon backbone for chemoenzymatic synthesis of heparin, a widely used clinical anticoagulant drug. The availability heparosan is significant concern cost-effective bioengineered heparin. source known pivotal factor affecting production. However, mechanism by which sources control biosynthesis unclear. In this study, we found that was influenced different sources. Glucose inhibits heparosan, while addition either fructose or mannose increases yield...
Summary Significant advances in the ecology, physiology and genetics of reductively dechlorinating bacteria have revealed their important environmental roles bioremediation global chlorine cycle. N 2 fixation has been widely observed symbiotic, associative free‐living bacteria. Here we show physiological molecular evidence that are capable fixing atmospheric nitrogen. Furthermore, some these stimulated reductive dechlorination, which should help predict regulate function situ chlorinated...
Seventeen out of 24 human flora-associated (HFA) piglets died after oral administration whole fecal flora from an apparently healthy donor. The bacteria isolated the organs infected were identified as Klebsiella pneumoniae by bacteriological and biochemical tests 16S rRNA gene sequence analysis. identical K. strain was also donor's flora. All three neonatal inoculated with developed severe diarrhea, 2 eventually dying. This strongly suggests that opportunistic pathogen donor caused fatal...
Guanting Reservoir in Yanqing County is a strategic drinking-water resource for Beijing, China. The agricultural soil samples (0 cm to 20 cm) were collected determine the concentration, compositional profiles, and sources of polycyclic aromatic hydrocarbons (PAHs) surrounding reservoir. average measured PAH concentration was 140 ± 85.7 μg kg−1 (CV = 0.45) (dry weight or dw; n 48; shown as arithmetic mean standard deviation), which lower than most results reported literature. profiles...