Letícia Szadai
A5025309445- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Advanced Proteomics Techniques and Applications
- Gastrointestinal disorders and treatments
- Cell Image Analysis Techniques
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
University of Szeged
2022-2025
Melanoma is a highly heterogeneous disease, and deeper molecular classification essential for improving patient stratification treatment approaches. Here, we describe the histopathology-driven proteogenomic landscape of 142 treatment-naïve metastatic melanoma samples to uncover subtypes clinically relevant biomarkers. We performed an integrative analysis identify proteomic subtypes, assess impact BRAF V600 mutations, study profiles cellular composition tumor microenvironment. Clinical...
Introduction While Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI therapy. Methods Evaluating previously reported two untreated melanoma cohorts, we used published model (EaSIeR score) identify potential distinguishing responders and non-responders. Results Six initially identified the cohort correlated with...
Abstract While Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI therapy. Evaluating previously reported two untreated melanoma cohorts, we used published model (EaSIeR score) identify potential distinguishing responders and non-responders. Six initially identified the cohort correlated with predicted cohort....