A5065766261- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- DNA and Nucleic Acid Chemistry
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Neuroscience and Neuropharmacology Research
- Supramolecular Chemistry and Complexes
- Health and Medical Research Impacts
- Analytical Chemistry and Chromatography
- History and advancements in chemistry
- Academic Writing and Publishing
- Analytical Chemistry and Sensors
- Digital Storytelling and Education
- Chemical Synthesis and Analysis
- Luminescence and Fluorescent Materials
- Chemical Reaction Mechanisms
- Antimicrobial Peptides and Activities
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Cystic Fibrosis Research Advances
- Career Development and Diversity
Tulane University
2018-2025
New York University
2016-2022
University of New Orleans
2020-2021
University of Southampton
2010-2019
University of Oxford
2015-2016
A series of easy-to-make fluorinated tripodal anion transporters containing urea and thiourea groups have been prepared their transport properties studied. Vesicle assays using ion-selective electrodes show that this class compound is capable transporting chloride through a lipid bilayer via variety mechanisms, including chloride/H(+) cotransport chloride/nitrate, chloride/bicarbonate, to lesser extent an unusual chloride/sulfate antiport process. Calculations indicate increasing the degree...
Square peg in a round ball: Squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea urea analogues. Studies into nature of this transport point mobile carrier mechanism, where squaramide delivers cargo across lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide platform development new generation anion-transport systems. Detailed facts importance specialist readers published as...
The transport of anions across cellular membranes is an important biological function governed by specialised proteins. In recent years, many small molecules have emerged that mimick the anion behaviour these proteins, but only a few synthetic also display gating/switching seen in systems. A series thiosquaramides was synthesised and their pH-dependent chloride binding investigated using 1H NMR titrations, single crystal X-ray diffraction variety vesicle-based techniques. Spectrophotometric...
Easy-to-make tripodal tris-thiourea receptors based upon tris(2-aminoethyl)amine are capable of chloride/bicarbonate transport and as such represent a new class bicarbonate agent.
Exceptionally powerful anion receptors have been constructed by placing squaramide groups in axial positions on a steroidal framework. The steroid preorganizes the NH such that they can act cooperatively bound anion, while maintaining solubility nonpolar media. acidic confer higher affinities than previously-used ureas or thioureas. Binding constants exceeding 10(14) M(-1) measured for tetraethylammonium salts chloroform employing variation of Cram's extraction procedure. also studied as...
The transport of anions across biological membranes by small molecules is a growing research field due to the potential therapeutic benefits these compounds. However, little known about exact mechanism which drug-like work and molecular features make good transporter. An extended series 1-hexyl-3-phenylthioureas were synthesized, fully characterized (NMR, mass spectrometry, IR single crystal diffraction) their anion binding properties assessed using 1H NMR titration techniques variety...
The transmembrane transport of anions by small synthetic molecules is a growing field in supramolecular chemistry and has focussed mainly on the chloride. On other hand, highly hydrophilic sulfate anion across lipid bilayers much less developed, even though inability to cellular membranes been linked variety genetic diseases. Tris-thioureas possess high affinities have shown be excellent chloride bicarbonate transporters. Herein we report abilities series tris-ureas tris-thioureas based...
Gated ion transport across biological membranes is an intrinsic process regulated by protein channels. Synthetic anion carriers (anionophores) have potential applications in research; however, previously reported examples are mostly nonspecific, capable of mediating both electrogenic and electroneutral (nonelectrogenic) processes. Here we show the transmembrane Cl– studies synthetic phenylthiosemicarbazones mimicking function acid-sensing (proton-gated) These anionophores remarkable...
Synthetic anion transporters are active in cystic fibrosis cells, and additive to clinically-approved drugs, suggesting new combination therapies for this lethal genetic condition.
Small molecule synthetic anion transporters may have potential application as therapeutic agents for the treatment of diseases including cystic fibrosis and cancer. Understanding factors that can dictate transport activity such is a crucial step towards their in biological systems. In this study series acylthiourea were synthesised binding properties POPC bilayers been investigated. The these receptors dominated by lipophilicity, which turn dependent on both substituent effects formation...
An oxothiosquaramide was shown to bind chloride through hydrogen bonding interactions in DMSO and found exhibit pH switchable transport across phospholipid bilayers <italic>via</italic> an antiport mechanism.
We report a dynamic covalent approach to transmembrane transport of amino acids by the formation three-component assembly. A mixture squaramide and lipophilic electrophilic aldehyde is shown synergistically highly polar glycine (Gly) across vesicle membranes. The was investigated 13C NMR assay, an osmotic response newly developed fluorescence assay suitable for measuring Gly influx, other assays leakage pH change. proposed occur via hydrogen-bonded anionic hemiaminal/imine, accompanied OH–...
A QSAR analysis of the transmembrane anion transport activity 43 synthetic tambjamine analogs allowed rationalization this according to their lipophilicity and structural parameters.
A systematic study of chloride vs. nitrate selectivity across six anion transporters has revealed a good correlation between the selectivities their binding and membrane transport properties. This work reveals limitations chloride-nitrate exchange assay shows how new approaches can be used to measure uniport.
Misregulation of transmembrane ion transport in biological systems has been linked to a variety diseases. As result, supramolecular chemists have trying develop small molecules that facilitate...
The formation of tren-based tris-urea supramolecular gels in organic solvents is perturbed by the presence nerve agent soman providing a new method sensing organophosphorus warfare agents.
The anion transport properties of a series previously reported tren-based anionophores have been revisited using new assays designed to measure uniport. This study provides insights into the mechanism and selectivity this important class transporters. Specifically, we report chloride nitrate these systems quantify sulfate determine EC50 values for first time. Two were developed bicarbonate allowing accurate quantification chloride/bicarbonate exchange.
A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many found to be effective Cl(-) and inhibit clinical strains Staphylococcus aureus growth in vitro. The best proved against the methicillin-resistant (MRSA) strains, Mu50 HP1173. Tris-thiourea tren-based chloride also shown S.