A5001084090- Enzyme Structure and Function
- Heat shock proteins research
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Protein Degradation and Inhibitors
- Advanced Proteomics Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Plant nutrient uptake and metabolism
- Wnt/β-catenin signaling in development and cancer
- Protein Structure and Dynamics
- Photosynthetic Processes and Mechanisms
- Microtubule and mitosis dynamics
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Carbohydrate Chemistry and Synthesis
University of Leeds
2018
St. Jude Children's Research Hospital
2016
National University of Singapore
2012-2014
Aurora-A regulates the recruitment of TACC3 to mitotic spindle through a phospho-dependent interaction with clathrin heavy chain (CHC). Here, we describe structural basis these interactions, mediated by three motifs in disordered region TACC3. A hydrophobic docking motif binds previously uncharacterized pocket on that is blocked most kinases. Abrogation causes delay late mitosis, consistent cellular distribution complexes. Phosphorylation Ser558 engages conformational switch second from...
Hakai, an E3 ubiquitin ligase, disrupts cell-cell contacts in epithelial cells and is up-regulated human colon gastric adenocarcinomas. Hakai acts through its phosphotyrosine-binding (HYB) domain, which bears a dimeric fold that recognizes the phosphotyrosine motifs of E-cadherin, cortactin, DOK1, other Src substrates. Unlike monomeric nature SH2 domains, architecture HYB domain consists atypical, zinc-coordinated tight homodimer. Here, we report C-terminal truncation mutant (HYB(ΔC)),...
Phosphorylation uncouples the functions of chaperone Hsp72 during mitosis.