A5034114327- Ovarian cancer diagnosis and treatment
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- Immune cells in cancer
- Mass Spectrometry Techniques and Applications
- Barrier Structure and Function Studies
- FOXO transcription factor regulation
- CRISPR and Genetic Engineering
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Bladder and Urothelial Cancer Treatments
- Reproductive Biology and Fertility
- Advanced Proteomics Techniques and Applications
- Viral-associated cancers and disorders
- Caveolin-1 and cellular processes
Skåne University Hospital
2017-2025
Lund University
2017-2025
Regional Cancer Center
2017
Medicon Village
2017
Abstract The response rate to checkpoint inhibitors for women with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is modest, development predictive biomarkers needed. main focus has been on tumor cell PD-L1 expression, but its assessment alone insufficient patient selection in most malignancies. We mapped presence macrophages (CD68 CD163) lymphocytes (CD3) located within epithelium, type–specific expression PD-1, their impact 5-year overall survival (OS) a...
Protein biomarkers for epithelial ovarian cancer are critical the early detection of to improve patient prognosis and clinical management disease monitor treatment response detect recurrences. Unfortunately, discovery protein is hampered by limited availability reliable sensitive assays needed reproducible quantification proteins in complex biological matrices such as blood plasma. In recent years, targeted mass spectrometry, exemplified selected reaction monitoring (SRM) has emerged a...
Abstract Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial many solid cancer types. Reports on TLS high-grade serous tubo-ovarian carcinoma (HGSC) few, and prognostic impact is unclear. We investigated mature (mTLS), immature (iTLS) aggregates (LA) primary adnexal tumors (PTs) synchronous omental/peritoneal metastases (pMets) of HGSC. Whole H&E slides were scrutinized for mTLS LA a population-based cohort 130 cases with stage III-IV The immune...
Studies have implied that fibroblasts may act as regulators of immune cells in the tumor microenvironment (TME). We investigated clinical relevance fibroblast activation protein (FAP) positive stroma high-grade serous ovarian cancer (HGSC) relation to CD8+ lymphocyte's infiltration. In a discovery cohort (N = 113) HGSC, expression FAP and CD8 TME was analyzed with immunohistochemistry. Results were correlated overall survival (OS) progression-free (PFS). The findings validated an independent...
The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of overexpression and whether expression could predict platinum response primary carcinoma (OC). Claudin-4 was evaluated by immunohistochemistry a tissue microarray 140 OCs. Multivariable Cox-regression models were used assess effect on progression-free survival overall (OS). Kaplan-Meier analyses logrank test performed comparing high low groups....
Abstract High-grade serous ovarian cancer (HGSOC) is the most common subtype of epithelial and early detection challenging. TP53 mutations are a hallmark HGSOC these in liquid-based Pap samples could provide method for diagnosis. Here we evaluate use IBSAFE, an ultra-sensitive droplet digital PCR (ddPCR) method, detecting collected from fifteen women at time diagnosis (diagnostic samples) and/or up to seven years prior (archival samples). We analysed tumours somatic with next generation...
ABSTRACT The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be marker of cells. We investigated the protein expression women with high-grade serous ovarian (HGSOC) determine its potential prognostic treatment predictive value. constructed tissue microarray 130 advanced stage HGSOC tumors an average 6 cores each, stained for evaluated survival outcomes. treated two lines carboplatin...
Overexpression of the receptor tyrosine kinase MET has been linked to poor survival in several cancer types, and suggested interact with stem cell networks. In vitro studies have further a possible benefit combined treatment using PARP inhibitors. We used tissue microarray (TMA) 130 samples advanced-stage high-grade serous fallopian tube/ovarian (HGSC) investigate prognostic value protein expression alone combination factor SOX2. The synergistic effects inhibitor were evaluated two lines...
<h3>Introduction/Background</h3> Tumor biology studies have implied that fibroblasts act as negative regulators of immune cell function in cancer. We investigated the impact FAP-positive cells high-grade serous ovarian cancer (HGSC) relation to CD8 expression. <h3>Methodology</h3> A discovery cohort (N=113) HGSC was subjected immunohistochemistry (IHC) FAP and CD8. Marker status correlated with overall survival (OS) progression-free (PFS). Findings were confirmed a validation (N=121) public...