A5044889497- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Impact on Reproduction
- Pregnancy and preeclampsia studies
- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Complement system in diseases
- Platelet Disorders and Treatments
- Neonatal and Maternal Infections
- Long-Term Effects of COVID-19
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 and healthcare impacts
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Ovarian function and disorders
- Radiopharmaceutical Chemistry and Applications
- Peripheral Neuropathies and Disorders
- Intramuscular injections and effects
- Kawasaki Disease and Coronary Complications
- Dermatological and COVID-19 studies
- Blood disorders and treatments
- Atherosclerosis and Cardiovascular Diseases
- HER2/EGFR in Cancer Research
Sechenov University
2021-2025
National Research Tomsk State University
2022-2024
Tomsk Polytechnic University
2022-2024
Far Eastern Federal University
2022
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2020
Unlike classic APS, CAPS causes multiple microthrombosis due to an increased inflammatory response, known as a “thrombotic storm”. typically develops after infection, trauma, or surgery and begins with the following symptoms: fever, thrombocytopenia, muscle weakness, visual cognitive disturbances, abdominal pain, renal failure, disseminated intravascular coagulation. Although presence of antiphospholipid antibodies in blood is one diagnostic criteria, level these can fluctuate significantly,...
The article delves into the systemic inflammatory response syndrome (SIRS), thromboinflammation, and septic shock in fetuses neonates, providing a comprehensive examination of their pathophysiology, diagnostic criteria, clinical implications. It establishes SIRS as hyper-reaction to external stress, disrupting balance between inflammation adaptive mechanisms, driven by cytokines like TNF-α IL-1. fetal (FIRS), subset SIRS, is highlighted for its role adverse neonatal outcomes, including organ...
Aim : to carry out a comparative analysis of the pathogenesis, clinical manifestations, diagnostic criteria as well therapeutic strategies vaccine-induced thrombotic thrombocytopenia (VITТ) and heparin-induced (HIT), two rare but potentially life-threatening conditions associated with antibody-dependent platelet activation. Materials Methods . Current data on epidemiology, presentation, diagnosis, treatment VITТ HIT have been reviewed including an existing scoring systems, laboratory tests,...
Aim : to study plasmapheresis (PP) effect on antiphospholipid syndrome (APS) treatment during preconception preparation and pregnancy. Materials Methods . A single-center, prospective, randomized, uncontrolled was conducted. total of 137 women aged 22 32 years diagnosed with APS-related habitual miscarriage were examined. The patients stratified as follows: main group consisted 73 underwent a PF course (7 procedures at stage); comparison – 64 not efferent therapy. Antiphospholipid antibodies...
Aim : to test the hypothesis about a connection between genetic and acquired thrombophilia, as well characteristics of delivery in women with placental abnormalities. Materials Methods. A prospective controlled cohort non-randomized interventional study assessing presence thrombophilia was conducted 135 Pregnant were divided into 3 groups: group 1 included 42 history abnormalities; 2 – 61 pregnant placenta previa first discovered during ongoing pregnancy; 32 recurrent previa. The control 120...
177Lu-labeled small-molecule prostate-specific membrane antigen (PSMA) targeted tracers are therapeutic agents for metastatic castration-resistant prostate cancer. Optimizing molecular design holds the potential to further enhance pharmacokinetic properties of PSMA-targeted while preserving their potent effects. In this study, six novel N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-(S)-l-lysine (DCL) urea-based PSMA ligand 2,2′,2″,2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic...
COVID-19 is an infectious disease caused by the beta-coronavirus SARS-CoV-2 that in 2020 has spread worldwide. In most severe patients, clinical picture begins with respiratory failure further deteriorating up to multiple organ failure. Development of coagulopathy adverse prognostic. Analyzing currently available data revealed 71.4 % and 0.6 survivors fatal cases, respectively, demonstrated signs overt disseminated intravascular coagulation (DIC). Monitoring D-dimer level, prothrombin time,...
Pulmonary thromboembolism (PTE) in pregnancy is one of the most common causes maternal mortality, causing hemodynamic instability and circulatory failure. The management these patients very challenging requires a rapid choice therapy, considering both fetal risks. Objective. To demonstrate approach to timely diagnosis treatment PTE during delivery using clinical case pregnant woman as an example. Patients methods. article presents patient at 31 weeks’ gestation. description based on...
The rate of thrombosis and disseminated intravascular coagulation (DIC) has been increasing in COVID-19 patients. Key features related to such condition include minimal or no risk bleeding, moderate thrombocytopenia, high plasma fibrinogen as well complement components level the areas thrombotic microangiopathy. clinical picture is not typical for classic DIC. This review systematizes pathogenetic mechanisms hypercoagulation sepsis its extreme forms patients with COVID-19. latter consist...
Magnesium is an important cofactor for metabolic reactions involving more than 300 enzymes, regulating a series of fundamental processes, such as myocardial contraction and blood pressure control, glucose regulation, participation in neuromuscular transmission. The prevalence magnesium deficiency various cohorts fertile age women comprises up to 73.8 %. In clinical studies it was demonstrated that associated with diseases states dysmenorrhea, premenstrual syndrome (PMS), polycystic ovary...
The article is dedicated to outlining the pathogenic mechanisms, diagnostic criteria, and treatment of systemic inflammatory response syndrome (SIRS), thromboinflammation, septic shock in fetuses newborns. SIRS a body hyperreaction external stress involving biologically active molecules, cytokines such as tumor necrosis factor-alpha (TNF-α) interleukin (IL) IL-1 so that balance between inflammation adaptive mechanisms becomes altered. Special attention paid fetal (FIRS). Here, we describe...
For last months, humanity has faced a formidable unknown enemy, which is presented as new coronavirus infection. Despite the fact that causative agents of diseases appear at certain frequency and virus SARS-CoV-2 common properties with its predecessors, moment we are dealing pathogenesis development severe complications in patients risk factors. A final understanding pathological process mechanisms goal scientific community. Summarizing research data from different countries, it became...
Background: Contracting COVID-19 during pregnancy can harm both the mother and unborn child. Pregnant women are highly likely to develop respiratory viral infection complications with critical conditions caused by physiological changes in immune cardiopulmonary systems. Asymptomatic pregnant may be accompanied fetal inflammatory response syndrome, which has adverse consequences for newborn’s life health. Purpose: To conduct an assessment of fetus due effects on determining pro-inflammatory...
The pandemic of a novel coronavirus infection COVID-19 has become real challenge to the mankind and medical community raised number social issues. Based on currently available information clinical cases, it follows that patients in critical condition exhibit picture disseminated intravascular coagulation (DIC), septic shock with developing multiple organ failure, which justifies use anticoagulant therapy patients. In addition isolating virus RNA from biological material polymerase chain...
Aim: to study a pattern of genetic and acquired thrombophilia in pregnant women with severe early-onset (eoPЕ) late-onset PE (loPЕ) preeclampsia (PE). Materials Methods. A retrospective cohort was conducted from January 2022 May 2024. total 109 were examined: group 1 – 45 eoPЕ (< 34 weeks pregnancy), 2 24 loPЕ (≥ 3 (control) 40 physiologically uncomplicated pregnancy. All examined for lupus anticoagulant (LA) antiphospholipid antibodies (aPL). The screening test aPL included the...
Abstract An issue of the novel coronavirus infection spreading is currently in first place among others list international medical community. Due to lack information, conflicting research findings, multicomponent effect virus on body host, as well various consequences that triggers body, now every specialty does study viral attack pathogenesis. Recent months showed vascular complications are most severe Coronavirus Disease 2019 (COVID-19) and main cause death patients. The mechanisms complex...
The pandemic of a new coronavirus infection (Coronavirus Disease 2019, COVID-19) caused by SARS-CoV-2 became real challenge to humanity and the medical community in 2020 raised number medical, social even philosophical questions. An almost avalanche-like increase infected people short time, due high contagiousness viral infection, allowed us identify groups patients with mild, moderate severe forms disease. Doctors around world are faced an acute problem treating large critical conditions...
This article summarizes numerous studies on the relationship of biological processes such as inflammation and thrombosis. The huge role neutrophils extracellular neutrophil traps (NETs) secreted by them has been demonstrated. discovery NETs opened new horizons in understanding biology these cells body. use chromatin combination with intracellular proteins, an effective antimicrobial agent ancient roots changes our only a carrier genetic information. Through NETs, can contribute to...
The spread of a new coronavirus infection worldwide since the end 2019 has becomes pandemic. Thrombotic complications are leading cause death in this disease. After entering human body, virus starts cascade reactions to development cytokine storm, activation all parts hemostasis and complement systems other changes that result disturbances circulation system with multiple organ failures. Numerous studies have shown predictor severe course COVID-19 is sharp increase D-dimer concentration...
Introduction . Currently, endothelial dysfunction caused by inflammation and immunothrombosisis considered as one of the crucial mechanisms in developing SARS-CoV-2 virus-mediated coronavirus disease 2019 (COVID-19). A mass damage followed release untypical large quantity von Willebrand factor (vWF) multimers subsequent consumption metalloproteinase ADAMTS-13 (a disintegrin with a thrombospondin type 1 motif, member 13) is described during severe COVID-19. The activation innate immune cells...
HER2 status determination is a necessary step for the proper choice of therapy and selection patients targeted treatment cancer. Targeted radiotracers such as radiolabeled DARPins provide noninvasive effective way molecular imaging expression. This study aimed to evaluate tumor-targeting properties three