A5065045097- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Marine Invertebrate Physiology and Ecology
- Amphibian and Reptile Biology
- Insect and Pesticide Research
- Vector-borne infectious diseases
- Yersinia bacterium, plague, ectoparasites research
- Ichthyology and Marine Biology
- Lepidoptera: Biology and Taxonomy
- Blood Coagulation and Thrombosis Mechanisms
- Ion channel regulation and function
The University of Queensland
2016-2023
The University of Melbourne
2020
Universeum
2019
Snakebite is a global tropical disease that has long had huge implications for human health and well-being. Despite its long-standing medical importance, it been the most neglected of diseases. Reflective this many aspects pathology have underinvestigated. by species in Elapidae family typically characterised neurotoxic effects result flaccid paralysis. Thus, while clinically significant disturbances to coagulation cascade reported, bulk research date focused upon neurotoxins. In order fill...
Lancehead pit-vipers (Bothrops genus) are an extremely diverse and medically important group responsible for the greatest number of snakebite envenomations deaths in South America. Bothrops atrox (common lancehead), majority snakebites related within Brazilian Amazon, is a highly adaptable widely distributed species, whose venom variability has been to several factors, including geographical distribution habitat type. This study examined venoms from four B. populations (Belterra Santarém,...
Australia is the stronghold of front-fanged venomous snake family Elapidae. The Australasian elapid radiation, which includes approximately 100 terrestrial species in Australia, as well Melanesian and all world's sea snakes, less than 12 million years old. incredible phenotypic ecological diversity clade matched by considerable venom composition. clade's evolutionary youth dynamic evolution should make it particular interest to toxinologists, however, majority species, are small, typically...
While snake venoms have been the subject of intense study, comparatively little work has done on lizard venoms. In this we examined structural and functional diversification anguimorph associated toxins, related these results to dentition predatory ecology. Venom composition was shown be highly variable across 20 species Heloderma, Lanthanotus, Varanus included in our study. kallikrein enzymes were ubiquitous, they also a particularly multifunctional toxin type, with differential activities...
The genus Bitis comprises 18 species that inhabit Africa and the Arabian Peninsula. They are responsible for a significant proportion of snakebites in region. venoms two independent lineages giant (B. arietans again common ancestor clade consisting B. gabonica, nasicornis, parviocula rhinoceros) induce an array debilitating effects including anticoagulation, hemorrhagic shock cytotoxicity, whilst dwarf atropos is known to have strong neurotoxic effects. However, venom other within not been...
Venomous snakes are important subjects of study in evolution, ecology, and biomedicine. Many venomous have alpha-neurotoxins (α-neurotoxins) their venom. These toxins bind the alpha-1 nicotinic acetylcholine receptor (nAChR) at neuromuscular junction, causing paralysis asphyxia. Several predators evolved resistance to α-neurotoxins. The is conferred by steric hindrance from N-glycosylated asparagines amino acids 187 or 189, an arginine position that has been hypothesized either...
Snakes of the genera Pseudocerastes and Eristicophis (Viperidae: Viperinae) are known as desert vipers due to their association with arid environments Middle East. These species have received limited research attention little is about venom or ecology. In this study, a comprehensive analysis viper venoms was conducted by visualising proteomes via gel electrophoresis assessing crude for cytotoxic, haemotoxic, neurotoxic properties. Plasmas sourced from human, toad, chicken were used models...
The snake genus Daboia (Viperidae: Viperinae; Oppel, 1811) contains five species: D. deserti, mauritanica, and palaestinae, found in Afro-Arabia, the Russell’s vipers russelii siamensis, Asia. are responsible for a major proportion of medically important snakebites that occur regions they inhabit, their venoms notorious coagulopathic effects. While widely documented, extent venom variation within is poorly characterised, as activity other species genus. In this study we investigated...
Venoms are a rich source of potential lead compounds for drug discovery, and descriptive studies venom form the first phase biodiscovery process. In this study, we investigated pharmacological crude Pseudocerastes Eristicophis snake venoms in haematological disorders cancer treatment. We assessed their antithrombotic using fibrinogen thromboelastography, gels with without protease inhibitors, colourimetric fibrinolysis assays. These assays indicated that anticoagulant properties likely...
Snake venoms constitute a complex, rapidly evolving trait, whose composition varies between and within populations depending on geographical location, age preys (diets). These factors have determined the adaptive evolution for predatory success link venom heterogeneity with prey specificity. Moreover, understanding evolutionary drivers of animal has streamlined biodiscovery venom-derived compounds as drug candidates in biomedicine biotechnology. The king cobra (Ophiophagus hannah; Cantor,...
The death adder Acantophis antarcticus (