A5064486704- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Heat shock proteins research
- Vaccine Coverage and Hesitancy
- Immune responses and vaccinations
- Misinformation and Its Impacts
- Physiological and biochemical adaptations
- Scientific Computing and Data Management
- Academic Publishing and Open Access
- SARS-CoV-2 detection and testing
- Genomics and Phylogenetic Studies
- Meat and Animal Product Quality
- Evolution and Genetic Dynamics
- COVID-19 diagnosis using AI
- Genetics, Aging, and Longevity in Model Organisms
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Genetic diversity and population structure
- Artificial Intelligence in Healthcare and Education
Azimuth (United States)
2020-2022
Temple University
2019-2022
Abstract HYpothesis testing using PHYlogenies (HyPhy) is a scriptable, open-source package for fitting broad range of evolutionary models to multiple sequence alignments, and conducting subsequent parameter estimation hypothesis testing, primarily in the maximum likelihood statistical framework. It has become popular choice characterizing various aspects process: natural selection, rates, recombination, coevolution. The 2.5 release (available from www.hyphy.org) includes completely...
The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world and infected hundreds of millions people with disease 2019 (COVID-19). While this viral species was unknown prior to January 2020, its similarity other coronaviruses that infect humans allowed for rapid insight into mechanisms it uses human hosts, as well ways immune system can respond. Here, we contextualize SARS-CoV-2 among identify what is known be inferred about behavior once inside a host....
Small heat shock proteins (sHSPs) emerged early in evolution and occur all domains of life nearly species, including humans. Mutations four sHSPs (HspB1, HspB3, HspB5, HspB8) are associated with neuromuscular disorders. The aim this study is to investigate the evolutionary forces shaping these during vertebrate evolution. We performed comparative analyses on a set orthologous sHSP sequences, based ratio non-synonymous: synonymous substitution rates for each codon. found that had been...
The COVID-19 pandemic catalyzed the rapid dissemination of papers and preprints investigating disease its associated virus, SARS-CoV-2. multifaceted nature demands a multidisciplinary approach, but urgency crisis combined with need for social distancing measures present unique challenges to collaborative science. We applied massive online open publishing approach this problem using Manubot. Through GitHub, collaborators summarized critiqued literature, creating review manuscript. Manubot...
Abstract Small heat shock proteins (sHSPs) emerged early in evolution and occur all domains of life nearly species, including humans. Mutations four sHSPs (HspB1, HspB3, HspB5, HspB8) are associated with neuromuscular disorders. The aim this study is to investigate the evolutionary forces shaping these during vertebrate evolution. We performed comparative analyses on a set orthologous sHSP sequences, based ratio non-synonymous: synonymous substitution rates for each codon. found that had...