A5057733932- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Cyberloafing and Workplace Behavior
Ulsan National Institute of Science and Technology
2020-2022
UV-activated alkyne-alkene [2 + 2] cycloaddition has served as an important tool to access cyclobutenes. Although broadly adopted, the limitations with UV light energy source prompted us explore alternative method. Here we report based on visible photocatalysis allowing synthesis of diverse cyclobutenes and 1,3-dienes via inter- intramolecular reactions. Extensive mechanistic studies suggest that localized spin densities at sp
We describe the electrochemical α-amidoalkylation of γ-lactams based on transition-metal-free cross-coupling via hydrogen atom transfer. The highly selective transfer process allows for a broad substrate scope including both inter- and intramolecular reactions. Also, construction quaternary centers was realized by double protocol to afford spirocycles. Detailed mechanistic studies experimental computational are provided support reaction pathway.
Cycloaddition reactions offer great advantages regarding atom and step economy for the construction of various carbocycles heterocycles. While recent development based on sensitized visible light photocatalysis allowed synthesis azetidines via imine-alkene [2 + 2] cycloaddition, imine-alkyne cycloaddition under has not been reported. In this regard, we report pyrrolizidinones intramolecular photocatalysis. This redox-neutral reaction involves formal metathesis followed by redox-mediated...
The synthesis of unsymmetrical dithioacetals based on gold catalysis is described. Although many approaches to the preparation symmetrical have been developed, methods access ones remain limited. In this regard, we report a mild synthetic method with broad substrate scope. Screening various catalysts identified catalyst, which allows hydrothiolation both activated and unactivated vinyl sulfides high efficiency. Moreover, reaction displays compatibility for aryl aliphatic thiols.