A5070276207- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Acute Myeloid Leukemia Research
- Blood groups and transfusion
- Reservoir Engineering and Simulation Methods
- Oil and Gas Production Techniques
- Erythrocyte Function and Pathophysiology
- Chemical Synthesis and Analysis
- Hydraulic Fracturing and Reservoir Analysis
- Hematological disorders and diagnostics
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Fluid Dynamics and Mixing
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Acute Myocardial Infarction Research
- Energetic Materials and Combustion
- Fluid Dynamics Simulations and Interactions
- Atrial Fibrillation Management and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Lipid metabolism and disorders
- RNA modifications and cancer
- Click Chemistry and Applications
University of Pennsylvania
2021-2024
University of Pamplona
2020-2023
Asociación Colombiana de Gastroenterología
2023
Asociación Colombiana de Hematología y Oncología
2023
University of Cambridge
2017
Broad Institute
2016
University of Florida
2014-2016
University of Alabama at Birmingham
2007
Petroleum of Venezuela (Venezuela)
2000-2003
Rice University
1997
Abstract The partnership of DNA deaminase enzymes with CRISPR-Cas nucleases is now a well-established method to enable targeted genomic base editing. However, an understanding how Cas9 and deaminases collaborate shape editor (BE) outcomes has been lacking. Here, we support novel mechanistic model editing by deriving range hyperactive activation-induced (AID) editors (hBEs) exploiting their characteristic diversifying activity. Our involves multiple layers previously underappreciated...
Nucleic acid structure plays a critical role in governing the selectivity of DNA- and RNA-modifying enzymes. In case APOBEC3 family cytidine deaminases, these enzymes catalyze conversion cytosine (C) to uracil (U) single-stranded DNA, primarily context innate immunity. DNA deamination can also have pathological consequences, accelerating evolution viral genomes or, when host genome is targeted by either APOBEC3A (A3A) or APOBEC3B (A3B), promoting tumor leading worse patient prognosis...
Efficient syntheses of chiral fragments derived from amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 fragments, including oxazolidinones, morpholinones, lactams, and sultams. These have molecular weights ranging 100 255 Da soluble water (0.085 >15 mM).
Stapled peptides have arisen as a new class of chemical probe and potential therapeutic agents for modulating protein-protein interactions. Here, we report the first two-component i,i+7 stapling methodology that makes use two orthogonal, on-resin reactions to incorporate linkers bearing chiral centre into p53-derived stapled peptide. Post-stapling modifications chain were performed enabled rapid access various peptide derivatives from single staple. The increased helicity, protease stability...
Abstract Introduction Flow cytometry (FC) is a helpful tool for the diagnosis of myelodysplastic syndrome (MDS). Different FC score systems have been developed. The “Ogata score” simple diagnostic that has validated having sensitivity 69% and specificity 92% in low‐risk MDS. We aimed to study feasibility utility MDS among Latin America (LA) Laboratories. Methods This case control conducted LA institutions members Grupo Latinoamericano de Mielodisplasia (GLAM). A total 146 patients 57 were...
Abstract Background: From 2017 to 2020, the American Society of Hematology (ASH) collaborated with 12 hematology societies in Latin America adapt ASH guidelines on venous thromboembolism (VTE). Objective: To describe methods used thromboembolism. Methods: Each society nominated 1 individual serve guideline panel. The work panel was facilitated by 2 methodologists. team selected 4 original VTE for a first round. select most relevant questions, 2-step prioritization process conducted through...
Background: Venous thromboembolism (VTE) is a common disease in Latin American settings. Implementing international guidelines settings requires additional considerations. Objective: The purpose of our study was to provide evidence-based about managing VTE for patients, clinicians, and decision makers. Methods: We used the Grading Recommendations, Assessment, Development Evaluation (GRADE)-ADOLOPMENT method adapt recommendations from 2 Society Hematology (ASH) (Treatment Anticoagulation...
Abstract A new mechanistic model to predict the natural separation efficiency in vertical pumped wells has been developed. The is based on combined phase momentum equations and a general slip closure relationship. New drag coefficient correlations have developed corresponding bubbly (i.e. undistorted particle) churn-turbulent flow regimes. indicates that depends strongly geometry, void fraction in-situ gas rate.
Abstract El Furrial reservoir is an important part of the new giant oil field recently discovered north Eastern Venezuela basin. Its medium gravity processed at large gas separation plant Jusepin. Serious problems have occurred concerning foam control and asphaltene depositions separators oil/gas lines due to crude carry-over containing abundant unstable asphaltenes. This paper presents laboratory studies performed in order evaluate best commercial inhibitors as well their optimum dosage...
Se presenta el analisis teorico del proceso de combustion que ocurre en quemadores gas natural. El comportamiento calor disponible, la eficiencia y las emisiones contaminantes, es evaluado funcion exceso aire temperatura los gases combustion. calcula valor maxima productos su relacion con precalentamiento aire. establecen consideraciones energeticas ambientales para perfeccionamiento operacion industriales.
Background Implementation of international guidelines in Latin American settings requires additional considerations (ie, values and preferences, resources, accessibility, feasibility, impact on health equity). Objective The purpose this guideline is to provide evidence-based recommendations about the diagnosis venous thromboembolism (VTE) its management children during pregnancy. Methods We used GRADE ADOLOPMENT method adapt from 3 Society Hematology (ASH) VTE (diagnosis VTE, pregnancy,...
Abstract A new mechanistic model to predict the natural separation efficiency in deviated pumped wells has been developed based upon combined phase momentum equations and a general slip closure relationship. The incorporates two important parameters that are both functions of flow pattern; local void fraction front pump intake ports drag coefficient. is, turn, function bubble rise velocity. uses existing velocity correlations by Hasan Kabir1 for bubbly slug flow. transition between is...
Abstract Background: Venous thromboembolism (VTE) is a common disease in Latin American settings. Implementation of international guidelines settings requires additional considerations. Objective: To provide evidence-based about VTE prevention for patients, clinicians, and decision makers. Methods: We used the GRADE ADOLOPMENT method to adapt recommendations from 2 Society Hematology (ASH) (Prevention Surgical Patients Prophylaxis Medical Patients). ASH 12 local hematology societies formed...
Summary A new mechanistic model to predict natural separation efficiency in vertical pumped wells has been developed. The is based on the combined phase momentum equations and a general slip-closure relationship. New drag-coefficient correlations have developed that correspond bubbly (i.e., undistorted particle) churn-turbulent flow regimes. indicates depends strongly geometry, void fraction, in-situ gas rate.
A Mechanistic Model to Predict Natural Gas Separation Efficiency in Inclined Pumping Wells A. F. Harun; Harun INTEC Engineering, Inc. Search for other works by this author on: This Site Google Scholar M. G. Prado; Prado U. of Tulsa J. C. Serrano; Serrano PDVSA D. R. Doty Paper presented at the SPE Production and Operations Symposium, Oklahoma City, Oklahoma, March 2001. Number: SPE-67184-MS https://doi.org/10.2118/67184-MS Published: 24 2001 Cite View Citation Add Manager Share Icon Twitter...