A5086415455- Viral Infections and Vectors
- Research on Leishmaniasis Studies
- Mosquito-borne diseases and control
- Inflammasome and immune disorders
- Trypanosoma species research and implications
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Complement system in diseases
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Blood groups and transfusion
Universidade Federal de São Paulo
2020-2025
Associação Fundo de Incentivo à Pesquisa
2024
Pontifícia Universidade Católica de Goiás
2019
To evaluate the effects of cannabis and/or cocaine use on inflammatory, oxidative stress status and circulating monocyte subsets in HIV-infected individuals under antiretroviral therapy.Soluble CD14 (sCD14), intestinal fatty acid-binding protein (IFABP), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-8, IL-10, C-reactive (CRP) markers were examined. The their activation cytokine production by peripheral blood mononuclear cells (PBMCs) HIV-1 infected upon lipopolysaccharide...
Zika virus (ZIKV) poses a significant threat due to its association with severe neurological complications, particularly during pregnancy. Although viruses exhibit tropism for neural cells, including astrocytes, the role of these cells in controlling ZIKV replication remains unclear. In this study, we demonstrated that induces caspase‐1 activation primary astrocytes despite absence classical signs inflammasome activation. Caspase‐1 and caspase‐11 double knockout ( caspase‐1/11 −/− )...
Chemokine receptor type 3 (CXCR3) plays an important role in CD8+ T cells migration during intracellular infections, such as Trypanosoma cruzi. In addition to chemotaxis, CXCR3 has been described the interaction between antigen-presenting and effector cells. We hypothesized that is fundamental T. cruzi-specific cell activation, function. Anti-CXCR3 neutralizing antibody administration acutely cruzi-infected mice decreased number of specific spleen, those had impaired activation cytokine...
A variety of signaling pathways are involved in the induction innate cytokines and CD8+ T cells, which major players protection against acute Trypanosoma cruzi infection. Previous data have demonstrated that a TBK-1/IRF3-dependent pathway promotes IFN-β production response to cruzi, but role for STING, main interactor these proteins, remained be addressed. Here, we STING is required IFN-β, IL-6, IL-12 infection absence negatively impacts activation IRF-dependent parasite. We reported no...
Deficiency in memory formation and increased immunosenescence are pivotal features of Trypanosoma cruzi infection proposed to play a role parasite persistence disease development. The vaccination protocol that consists prime with plasmid DNA followed by the boost deficient recombinant human adenovirus type 5, both carrying ASP2 gene T. , is powerful strategy elicit effector CD8 + T-cells against this parasite. In virus infections, inhibition mTOR, kinase involved several biological...
<title>Abstract</title> The Zika virus (ZIKV) poses a significant threat due to its association with severe neurological complications, particularly during pregnancy. Although viruses exhibit tropism for neural cells, including astrocytes, the role of these cells in controlling ZIKV replication remains unclear. In this study, we demonstrated that induces caspase-1 activation primary astrocytes despite absence classical signs inflammasome activation. Caspase-1/11<sup>−/−</sup> heightened...
Complement mediated interference with the detection of antibodies targeting HLA is a known limitation single antigen bead (SAB) Luminex assay. Ethylenediaminetetraacetic acid (EDTA) currently serum treatment choice in most histocompatibility laboratories to block complement activation by chelating calcium. The purpose this study was investigate an antibody reactivity HLA-DQ6, 7, 8 and 9 molecules, SAB assay, that inhibited EDTA. Serum from 55-year-old highly sensitised female renal...
<title>Abstract</title> Zika virus (ZIKV) poses a significant threat due to its association with severe neurological complications, particularly during pregnancy. Although viruses exhibit tropism for neural cells, including astrocytes, the role of these cells in controlling ZIKV replication remains unclear. In this study, we demonstrated that induces caspase-1 activation primary astrocytes despite absence classical signs inflammasome activation. Caspase-1/11<sup>-/-</sup> heightened...