A5080946891- Viral Infections and Vectors
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- T-cell and Retrovirus Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Regulation of Appetite and Obesity
Universidade Estadual de Campinas (UNICAMP)
2022-2025
Universidade do Estado de Santa Catarina
2025
Obesity is a major concern for global health care systems. Systemic low-grade inflammation in obesity risk factor insulin resistance. Leptin an adipokine secreted by the adipose tissue that functions controlling food intake, leading to satiety. levels are increased obesity. Here, we show leptin enhances effects of LPS macrophages, intensifying production cytokines, glycolytic rates, and morphological functional changes mitochondria through mTORC2-dependent, mTORC1-independent mechanism. also...
Invariant natural killer T (iNKT) cells are a distinct population of lymphocytes characterized by their reactivity to glycolipids presented CD1d. iNKT found throughout the body, and little is known about tissue-specific metabolic regulation. Here, we show that splenic hepatic metabolically comparable rely on glycolytic metabolism support activation. Deletion pyruvate kinase M2 (Pkm2) gene in impairs response specific stimulation ability mitigate acute liver injury. In contrast, adipose...
Abstract Enzootic Bovine Leukosis (EBL), is infectious disease affecting especially older animals, although animals of all ages can be infected with the Leukemia Virus (BLV). Crioula Lageana a locally adapted, rustic and long-lived bovine breed, important as genetic resource. However, little known about its health status, making it difficult to preserve breed. In this sense, study aims assess prevalence EBL/BLV in different animal categories cattle. Then, blood samples were collected from...
Zika virus (ZIKV) poses a significant threat due to its association with severe neurological complications, particularly during pregnancy. Although viruses exhibit tropism for neural cells, including astrocytes, the role of these cells in controlling ZIKV replication remains unclear. In this study, we demonstrated that induces caspase‐1 activation primary astrocytes despite absence classical signs inflammasome activation. Caspase‐1 and caspase‐11 double knockout ( caspase‐1/11 −/− )...
<title>Abstract</title> The Zika virus (ZIKV) poses a significant threat due to its association with severe neurological complications, particularly during pregnancy. Although viruses exhibit tropism for neural cells, including astrocytes, the role of these cells in controlling ZIKV replication remains unclear. In this study, we demonstrated that induces caspase-1 activation primary astrocytes despite absence classical signs inflammasome activation. Caspase-1/11<sup>−/−</sup> heightened...
<title>Abstract</title> Zika virus (ZIKV) poses a significant threat due to its association with severe neurological complications, particularly during pregnancy. Although viruses exhibit tropism for neural cells, including astrocytes, the role of these cells in controlling ZIKV replication remains unclear. In this study, we demonstrated that induces caspase-1 activation primary astrocytes despite absence classical signs inflammasome activation. Caspase-1/11<sup>-/-</sup> heightened...